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A&R: Antiphospholipid antibodies increase endometrial stromal cell decidualization, aging, and inflammation via Toll-like receptor 4, reactive oxygen species, and p38 MAPK signaling

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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Objective: Miscarriage affects one in seven pregnancies, and antiphospholipid autoantibodies (aPL) are one of the greatest risk factors for recurrent miscarria.

Objective: Objective: Miscarriage affects one in seven pregnancies, and antiphospholipid autoantibodies (aPL) are one of the greatest risk factors for recurrent miscarria.

Methods : EnSCs under decidual conditions were exposed to aPL or control IgG alone, or to Toll-like receptor 4 (TLR-4) antagonist, p38 MAPK (mitogen-activated protein kinase) inhibitor, reactive oxygen species (ROS) inhibitor agents, low molecular weight heparin (LMWH), or acetylsalicylic ac.

Methods : EnSCs under decidual conditions were exposed to aPL or control IgG alone, or to Toll-like receptor 4 (TLR-4) antagonists, p38 MAPK (mitogen-activated protein kinase) inhibitors, reactive oxygen species (ROS) In the presence of inhibitors, low molecular weight heparin (LMWH) or acetylsalicylic ac.

Results: Results: Antiphospholipid antibodies increased human EnSC decidua, senescence and inflammati.

Conclusions Conclusions : These findings provide new clues to the pathogenesis of pregnancy complications in antiphospholipid autoantibody-positive women and highlight the benefits of heparin in preventing miscarriage in this high-risk populati.

Tong,.
, Kayani,.
, Jones, DM, Salmon, JE, Whirledge,.
, Chamley, LW and Abrahams, VM (2022), Antiphospholipid Antibodies Increase Endometrial Stromal Cell Decidualization, Senescence, and Inflammation via Toll-like Receptor 4, Reactive Oxygen Species, and p38 MAPK Signali.
Arthritis Rheumatol, 74: 1001-101https://d.
org/11002/a.
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