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Immune cytokines and systemic sclerosis
Time of Update: 2022-08-16
This article was originally created by the "Qinghe Health Alliance" platformThis article was originally created by the "Qinghe Health Alliance" platform This article was originally created by the "Qin
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Rheumatology: Evidence of subclinical atherosclerosis in eosinophilic granulomatosis with polyangiitis (EGPA)
Time of Update: 2022-08-16
No significant correlations were found between CCA-IMT, ANCA status, other clinical features, and treatment regimens were comparableConclusions: Ultrasound markers of subclinical atherosclerosis were increased in patients with EGPA compared with controls , independent of traditional cardiovascular risk factors .
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A&R: The role of necroptosis on myofiber death in idiopathic inflammatory myopathy
Time of Update: 2022-08-16
Methods Western blotting and immunohistochemical analysis were performed to examine the expression of receptor-interacting protein 3 (RIP-3) and MLKL proteins , as well as necroptosis -related injury - related molecules in 26 IIM patients and 4 healthy controls.
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A&R: Antibodies to cartilage oligomeric matrix protein (COMP) are pathogenic in mice and may be clinically relevant to rheumatoid arthritis
Time of Update: 2022-08-16
Methods We investigated the pathogenicity of monoclonal anti- COMP antibodies in mice using passive transfer experiments and explored the interaction of anti- immune COMP antibodies with cartilage using immunohistochemical staining .
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ARD: What Causes Inconsistency in Outcome Measurements in SLE Clinical Trials?
Time of Update: 2022-08-16
OBJECTIVE : In the anifrolumab (type I interferon receptor monoclonal antibody) systemic lupus erythematosus (SLE) trial program, there is a trial (TULIP-1) in which the BILAG - based Comprehensive Lupus Assessment (BICLA) anifrolumab response was superior to placebo treatment , but the SLE response index (SRI(4)) treatment did not differ significantly .
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A&R: choroid plexus infiltrating T cells drive neuropsychiatric lupus in mice
Time of Update: 2022-08-16
42252 leave a message here Objective : T cells are crucial in the pathogenesis of systemic lupus erythematosus (SLE) by secreting inflammatory cytokines, helping autoantibody production, and forming autoreactive memory T cells .
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ARD: Baricitinib in recurrent giant cell arteritis: a 52-week prospective open-label pilot study
Time of Update: 2022-08-16
Methods We conducted a prospective, open-label pilot study of baricitinib ( 4 mg/ day) with graded glucocorticoids ( GC ) and accelerated tapering in patients with recurrent GCA .
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ARD: Increased immunogenicity after a third dose of homologous inactivated SARS-CoV-2 vaccine in a large number of autoimmune rheumatic patients in Brazil
Time of Update: 2022-08-16
Objectives : To determine the immunogenicity of a third dose of CoronaVac vaccine in a large number of patients with autoimmune rheumatic disease (ARD) and factors associated with impaired response .
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ARD: Tofacitinib and Risk of Cardiovascular Outcomes: Results of the Safety of Tofacitinib in Usual Care Patients with Rheumatoid Arthritis (STAR-RA) Study
Time of Update: 2022-08-16
Objectives: Recent results from the " ORAL Surveillance" trial have raised concerns about the cardiovascular safety of tofacitinib in patients with rheumatoid arthritis (RA) . The research team furthe
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Hydroxychloroquine may have preventive effect on cardiovascular disease in rheumatic diseases
Time of Update: 2022-08-16
Data in recent years suggest that HCQ may have other beneficial effects beyond its ability to control disease activityIt has been investigated whether hydroxychloroquine treatment is associated with major adverse cardiovascular events (MACE) (myocardial infarction, ischemic stroke, or cardiovascular-related death) in patients with cutaneous lupus erythematosus (CLE) or systemic lupus erythematosus (SLE) .
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Hydroxychloroquine in the eyes of "systemic rheumatoid lupus"
Time of Update: 2022-08-16
. New methods such as computer-controlled perimeter and optical coherence tomography (OCT) enable early detection of damage caused by the use of HCQ, which has led to changes in dosing recommendations and monitoring of patients undergoing treatment, as new methods suggest that receiving lower doses of patients experience no retinal damage at all when receiving higher doses or long-term cumulative therapy .
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Biologics can dramatically improve quality of life for tonic patients, 'greatest work' isn't just in the arts
Time of Update: 2022-08-16
The application of combined vascular biologics in AS (the grapevine said that Jay Chou used gram)Biologics have irreplaceable advantages for ankylosing spondylitisBiologics have irreplaceable advantages in ankylosing spondylitis Biologics have irreplaceable advantages in ankylosing spondylitis Fast onset, can quickly relieve joint pain and swelling; Inhibition of bone destruction is better than traditional disease-modifying anti-rheumatic drugs; The drug is more targeted and can precisely block tumor necrosis factor, which can play a key role in the important link of pathogenesis .
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A&R: Longitudinal immune cell profiling in early systemic lupus erythematosus
Time of Update: 2022-08-16
Longitudinal mass spectrometry and multiplex serum cytokine analysis of samples from patients with early SLE revealed that Tfh cells and CXC motif chemokine ligands10 ( CXCL10 ) declined one year after enrollment .
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The pace of lupus research has never stopped, and these new discoveries are expected to light up the "healing light"!
Time of Update: 2022-08-16
Gene mutation leading to loss of function FcγR IIB is an important receptor on the surface of immune cells, which can bind to IgG-type Fc receptors to exert an immunosuppressive effect.
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Urine routine protein is negative and urine microalbumin is high, the reason is...
Time of Update: 2022-08-16
Therefore, the urine sample was first examined and found to have a cloudy appearance, as shown in the following figure:Because the sensitivity of urine microalbumin determination is higher than that of urine dry chemical protein determination, it is common sense that the urine microalbumin is slightly elevated and the urine routine protein is negative in the early stage of kidney injury.
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2022 Roche Osteoporosis Academic Salon - Watch the live broadcast to get 100 points and 99 guides for free!
Time of Update: 2022-08-16
leave a message here Two easy steps to get guide and watch liveguideStep 1: Scan the code to register the applet, pay attention to select the identity and fill in the information Step 2: Scan the code to receive after filling in the information for the registration of the appletStep 2: After filling in the information in the mini program registration , scan the code to receive the information.
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In the mid-summer season, probiotics help you improve immunity and disease prevention
Time of Update: 2022-08-16
Some patients with fever may feel that even if they sweat, the fever will not subside and other characteristics of fever and coldModern medicine also believes that summer is a period of vigorous growth and reproduction of bacteria, viruses and other microorganisms.
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Ways to Manage Rheumatoid Arthritis Pain
Time of Update: 2022-08-16
Opioid pain relievers:Opioid pain relievers:Opioids are mainly suitable for patients with moderate to severe chronic pain who use NSAIDs and other poor efficacy, or cannot tolerate the adverse reactions of gastrointestinal tract, cardiovascular and other adverse reactions caused by NSAIDs .
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A&R: The essential role of hematopoietic PAD4 in arthritis: collagen and granulocyte colony-stimulating factor-induced arthritis in the C57BL/6 mouse model
Time of Update: 2022-08-16
In the G-CSF- modified CIA model , Padi4 -/- mice developed milder arthritis, lower serum interleukin- 6 and plasma Cit-H3 levels, and synovial tissue compared with Padi4 +/+ mice Medium Cit-H4 levels were lower and microcomputed tomography showed less bone erosion .
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Not just rheumatism immunity!
Time of Update: 2022-08-16
The effect of HCQ on ABT-263-induced antitumor activity was examined using three human pancreatic cancer cell lines (PANC-1, MiaPaCa-2, and BxPC-3)Results: Combination treatment of HCQ and ABT-263 synergistically reduced the viability of BxPC-3 cells alone .