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BMJ: Study on the effect of vaccination against COVID-19 in immunocompromised people
Time of Update: 2022-04-16
11 studies show a third dose of COVID-19mRNA vaccines achieve seroconversion rates in previously unresponsive patients with solid tumors, hematological tumors, and immune-mediated inflammatory diseases .
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Degradation of negative immune regulators enhances immune responses
Time of Update: 2022-03-09
Text: Xiaotong Liu, Yuanyuan Zhou and Dongping Lu Translated by: Yuanlong Liu, TPC Assistant Features Editor The research paper "dependent protein kinase CPK28 is targeted by the ubiquitin ligases ATL31 and ATL6 for proteasome-mediated degradation to fine-tune immune signaling in Arabidopsis" revealed the regulation of innate immunity in Arabidopsis .
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Study reveals novel immune response mechanism against Streptococcus pyogenes infection
Time of Update: 2022-03-09
This study is the first to discover and report that the Streptococcus pyogenes GAS virulence factor SpeB triggers skin epithelial cell pyroptosis and inhibits its systemic infection by cleaving and activating GSDMA .
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Controversy guide update!
Time of Update: 2022-03-09
Professor Zhang Xuewu from the Institute of Rheumatism and Immunity, Peking University People's Hospital, gave a presentation on the difficulties in the diagnosis and treatment of gout arthritis, from the trend of hyperuricemia in the younger generation, the classification standard of gout, to the treatment of gout, and the interpretation of gout guidelines in recent years.
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Nature Immunology Mapping the immune regulatory network of human Mycobacterium tuberculosis granulomas
Time of Update: 2022-03-09
In this study, we performed analysis of cellular composition, mapping of spatial distribution, and exploration of immune regulatory pathways in granulomas following Mycobacterium tuberculosis infection, and established a link between granulomas and peripheral immune responses, for the development of host-oriented immune responses.
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China's first "fibromyalgia" rehabilitation guide, answers 20 important questions!
Time of Update: 2022-03-09
Individualization: Immediately after the diagnosis, a comprehensive rehabilitation evaluation of the patient is required to identify the symptoms that have the greatest impact on the patient, as well as pain intensity, function, mood, fatigue, and sleep disorders, and an individualized treatment plan is formulated based on the patient's specific situation .
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Science Shanghai Institute of Materia Medica Xu Huaqiang/Yin Wanchao Reveal the Molecular Mechanism of Rapid Spread and Immune Escape of Omicron Variants
Time of Update: 2022-03-09
In cooperation with Jimin Xinxin Deng Sujun's team, Xu Huaqiang and Yin Wanchao's team from Shanghai Institute of Materia Medica, Chinese Academy of Sciences further conquered the structure of Omicron mutant spike protein and specific therapeutic antibody JMB2002 (Figure 2A-C) .
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Studying the Plant Cell of pepper, revealing that the Xanthomonas type III effector XopS regulates the defense response and stomatal immunity of pepper
Time of Update: 2022-03-09
Vesicatoria (Xcv), and that the Xanthomonas effector protein XopS is Inhibition of defense gene expression enhances disease susceptibility, revealing its importance in suppressing stomatal immunity .
After incubating leaves of CaWRKY40a-silenced plants with different Xcv strains for 2 h, the stomatal pore size of leaves was significantly reduced (Fig.
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There are inexplicable spots on the body, don't ignore it, it is probably because of TA
Time of Update: 2022-03-08
01 Skin involvement is a common symptom and is a necessary condition for the diagnosis of IgA vasculitis .
03 Symptomatic treatment is the main treatment for patients with mild gastrointestinal tract involvement, diet is controlled, and low-dose glucocorticoids should be added if necessary .
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Express is expected to benefit infants and young children with eczema, Dupixent is granted priority review
Time of Update: 2022-03-08
S. Food and Drug Administration (FDA) has granted Dupilumab (dupilumab, English trade name Dupixent) a supplemental biological product Priority review eligibility for licensure application (sBLA) as add-on maintenance therapy in children 6 months to 5 years of age with moderate-to-severe atopic dermatitis .
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Nature Aging Xiao Guozhi/Cao Huiling team reveals the molecular mechanism of osteoarthritis
Time of Update: 2022-03-08
In terms of molecular mechanism, the team found that knockout of Kindlin-2 can activate the chondrocyte Stat3-Runx2 pathway, leading to abnormal hypertrophic differentiation of articular chondrocytes, extracellular matrix catabolism and the occurrence and development of OA .
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AS patients are on average 8 years delayed in diagnosis?
Time of Update: 2022-03-08
*For medical professionals to read and reference, together with experts in rheumatology and immunology, to explore the progress of AS diagnosis and treatment . On January 22-23, 2022, under the guid
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PNAS plant immunity: XA21-mediated bacterial infection resistance in rice
Time of Update: 2022-03-08
The XA21 immunoreceptor specifically recognizes RaxX (required for the activation of XA21-mediated immune X), a sulfated microbial peptide secreted by the Gram-negative bacterium Bacterial blight oryzae .
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Plant Cell Plasticity of plant innate immunity, Shui Wang group of Shanghai Normal University reports that RNA processing complex regulates plant immunity
Time of Update: 2022-03-08
Editor-in-Chief | Wang Yi On February 8, 2022, Wang Shui's research group from Shanghai Normal University published a research titled CONSTITUTIVE EXPRESSER OF PATHOGENESIS-RELATED GENES 5 is an RNA-binding protein controlling plant immunity via an RNA processing complex online in The Plant Cell thesis .
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【EMBO J】Receptor kinase FERONIA: how plants recognize "enemy" and "friend"
Time of Update: 2022-03-08
Molecular mechanism of PHR1 regulation of Arabidopsis RALF-FERONIA receptor kinase pathway The above work provides new material for the interesting topic of how plant roots recognize and prevent harmful microorganisms while recruiting beneficial microorganisms .
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up to date!
Time of Update: 2022-03-08
With the application of immunosuppressive agents and biological agents such as cyclophosphamide and mycophenolate mofetil, the prognosis of SLE has been greatly improved, but there are still many patients who are in a state of alternating relapse and remission or persistent disease activity for a long time .
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Treating silver, skin and bones, PsA diagnosis and treatment "Art of War" is here!
Time of Update: 2022-03-07
Figure 3 Assessment tools for different clinical phenotypes of PsA PsA is a systemic disease, in addition to skin lesions and joint symptoms, patients often have metabolic syndrome, cardiovascular disease, uveitis, digestive system, fatigue, anxiety/depression This further exacerbates the complexity of PsA .
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Science｜Dr. Liu Dan et al. report the role of CD97 in maintaining homeostasis and function of type 2 dendritic cells in the spleen
Time of Update: 2022-03-07
Cyster at the University of California, San Francisco (first authors are Dan Liu and Dan Liu) published a research paper CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells in the journal Science, revealing that The role of CD97 in maintaining dendritic cell homeostasis in the spleen by mechanosensing red blood cells .
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Basic and clinical breakthroughs!
Time of Update: 2022-03-07
Professor Yang Chengde, Department of Rheumatology and Immunology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, shared the research progress of antiphospholipid syndrome (APS) in 2021 during the meeting .
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Nature Aging Southern University of Science and Technology Xiao Guozhi/Cao Huiling/Bai Xiaochun discovers potential therapeutic targets for osteoarthritis
Time of Update: 2022-03-07
Deletion of Kindlin-2 in articular chondrocytes causes spontaneous osteoarthritis and exacerbates instability-induced osteoarthritis damage in adult mice .
Pharmacological inhibition of STAT3 activation or gene knockout in chondrocytes reversed the abnormal accumulation of Runx2 and extracellular matrix-degrading enzymes, and limited OA exacerbation caused by kindlin-2 deficiency .
