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Science sub-journal: Imbalance of intestinal butyrate metabolizing bacteria is related to the pathogenesis and development of rheumatoid arthritis
Time of Update: 2022-03-06
Recently, Li Zhanguo's team from the Department of Rheumatology and Immunology, Peking University People's Hospital, and the team of Associate Researcher Kang Yu from Beijing Institute of Genomics, Chinese Academy of Sciences (National Center for Bioinformatics) collaborated to publish a paper entitled: Intestinal butyrate-metabolizing species contribute to autoantibody in Science Advances, a sub-journal of Science Research paper on production and bone erosion in rheumatoid arthritis .
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The courier bag has received innovative treatments such as trispecific cytokine inhibitors, and the new sword is aimed at immune inflammatory diseases
Time of Update: 2022-03-06
Bioniz's lead product candidates are multispecific inhibitors that simultaneously target multiple clinically validated disease-driving cytokines, including potential "first-in-class" therapies BNZ-1 and BNZ-2 in clinical development, aimed at Addressing unmet needs in a range of immuno-inflammatory indications .
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Immunity Feng Jue et al. used clonal lineage tracing to reveal the common origin of traditional dendritic cells and plasmacytoid dendritic cells
Time of Update: 2022-03-06
Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells.
This coupled with CITE-Seq analysis of differentiated hematopoietic stem cells and Cx3cr1+ progenitors identified progressive stages of pDC development including Cx3cr1+ Ly-6D+ pro-pDCs distinct from lymphoid progenitors .
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Inventory of the new progress of CTD-PAH and interstitial lung disease!
Time of Update: 2022-03-06
A study published in the journal Lancet Respir Med in 2020 found that for SSc-ILD patients, tocilizumab was able to improve lung function and delay disease progression (Figure 5) .
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Top Issue Highlights: Gout + Nephropathy, Is It Safe to Use Allopurinol?
Time of Update: 2022-03-06
Two clinical trials of allopurinol in chronic kidney disease (CKD) showed no benefit and a possible increased risk of death .
The purpose of this study was to evaluate the all-cause mortality of allopurinol and escalating doses of allopurinol in patients with gout and chronic kidney disease.
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You Fuping's Team Reveals New Mechanism of Innate Immune Signals Regulating m⁶A Modification Cell Press Dialogue with Scientists
Time of Update: 2022-03-06
Life science On February 15, 2022, You Fuping's team from the Institute of Systems Biomedicine, Peking University School of Medicine and the Department of Immunology, School of Basic Medicine published an article entitled "TBK1-METTL3 axis facilitates antiviral in Cell Reports, a journal of Cell Press.
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Front Immunol: B and T cell responses following SARS-CoV-2 vaccine in patients with multiple sclerosis receiving disease-modifying therapy
Time of Update: 2022-03-05
Front Immunol 2021;12Iannetta M, Landi D, Cola G, B- and T-Cell Responses After SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Receiving Disease Modifying Therapies: Immunological Patterns and Clinical Implications.
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TAMD: FRAX tool to assess fracture risk in patients with systemic lupus erythematosus
Time of Update: 2022-03-05
OBJECTIVE: To compare fracture incidence observed in a 10-year longitudinal cohort of patients with systemic lupus erythematosus (SLE) with fracture risk predicted by the Fracture Risk Assessment (FRAX) tool .
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Sanofi/Regeneron's Dupixent underperforms in second chronic spontaneous urticaria study
Time of Update: 2022-03-05
Last year, the companies reported that the late-stage LIBERTY-CUPID A trial demonstrated that Dupixent (dupilumab) achieved its primary and key secondary endpoints in biologic-naïve patients with moderate-to-severe CSU, adding the drug to anti-inflammatory drugs.
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How is neuropsychiatric lupus managed?
Time of Update: 2022-03-05
Glucocorticoids are the primary treatment for NPSLE with underlying mechanisms of SLE disease activity , such as aseptic meningitis, optic neuritis, transverse myelitis, peripheral neuropathy, refractory epilepsy, psychosis, and acute delirious states .
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Front Immunol: Preliminary results of a propensity-matched trial of mycophenolate mofetil versus azathioprine in treatment-naïve AIH patients
Time of Update: 2022-03-05
As previous real-world studies and meta-analyses suggest that mycophenolate mofetil (MMF) may have better efficacy than azathioprine (AZA) in the treatment of autoimmune hepatitis (AIH), we conducted a propensity-matched study to evaluate MMF and the efficacy and safety of AZA .
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Chronic inflammation as a potential mechanism for the development of psoriasis-induced lung disease
Time of Update: 2022-03-05
Immunized children with hypertension and diabetes have demonstrated higher prevalence of psoriatic lung disease in asthma, chronic obstructive pulmonary disease, obstructive sleep apnea, and pulmonary hypertension .
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Front Immunol: Uveitis is a risk factor for developing acute myocardial infarction from ankylosing spondylitis
Time of Update: 2022-03-05
This study aimed to investigate whether uveitis is a risk factor for acute myocardial infarction (AMI) in AS patients using the National Health Insurance Research Database (NHIRD) .
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J Neuroinflammation: Lowering blood cholesterol does not affect neuroinflammation in experimental autoimmune encephalomyelitis
Time of Update: 2022-03-04
We evaluated the role of circulating cholesterol in a mouse model of experimental autoimmune encephalomyelitis (EAE) disease MS using two different approaches: (1) familial hyperlipidemia caused by low-density lipoprotein receptor (LDLR) deficiency A mouse model of cholesterolemia; (2) the use of the anti-PCSK9 neutralizing antibody alirocumab, which reduces the degradation of LDLR, thereby lowering blood cholesterol levels .
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Front Immunol: Genetic susceptibility to IL-13 in bullous pemphigoid: a potential target for therapy and a prognostic marker
Time of Update: 2022-03-04
These include activation of complement, aggregation of neutrophils and eosinophils, increased expression of cytokines, and secretion of proteolytic enzymes .
Interestingly, gene polymorphisms of various cytokines have also been reported in some other autoimmune diseases .
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AstraZeneca's Saphnelo gets EU approval for systemic lupus erythematosus
Time of Update: 2022-03-04
The European approval was supported by the Phase III TULIP-1 and -2 studies and the interim MUSE trial investigating the efficacy and safety of intravenous Saphnelo (anifrolumab) in patients with moderate to severe SLE .
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Science Advances: Imbalance of gut butyrate metabolizing bacteria is associated with the pathogenesis and development of rheumatoid arthritis
Time of Update: 2022-03-04
Rheumatoid arthritis is an autoimmune disease of complex etiology characterized by joint destruction, systemic organ involvement, and elevated titers of autoantibodies such as anti-citrullinated pepti
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Br J Dermatol: Increased cancer risk in patients with psoriasis and venous thromboembolism
Time of Update: 2022-03-04
To estimate the possible increase in relative cancer risk, we calculated age, sex and calendar period (1996-2018) standardized incidence rates (SIRs) and associated 95% confidence intervals (CIs) using the Danish national cancer rate to compare observed silver Cancer incidence and expected incidence in patients with psoriasis and VTE .
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Front Immunol: The causal relationship between the gut microbiome and autoimmune disease
Time of Update: 2022-03-04
In this study, we performed a comprehensive two-sample MR analysis of 6 ADSs including SLE, RA, IBD, MS, T1D and CED, aiming to explore the causal relationship between the gut microbiota and multiple ADSs .
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Front Immunol: A retrospective study of the replacement and immunomodulatory activity of 20% subcutaneous immunoglobulin in patients with autoimmune myositis and CVID
Time of Update: 2022-03-04
Results support the beneficial effect and tolerability of 20% SCIg long-term treatment in PM/DM patients, reporting creatine kinase levels, muscle strength, skin condition, dysphagia, disease activity (MITAX score), and disability (HAQ-DI score) Significant improvement .
