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Front Immunol: The causal relationship between the gut microbiome and autoimmune disease
Time of Update: 2022-03-04
In this study, we performed a comprehensive two-sample MR analysis of 6 ADSs including SLE, RA, IBD, MS, T1D and CED, aiming to explore the causal relationship between the gut microbiota and multiple ADSs .
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Br J Dermatol: Increased cancer risk in patients with psoriasis and venous thromboembolism
Time of Update: 2022-03-04
To estimate the possible increase in relative cancer risk, we calculated age, sex and calendar period (1996-2018) standardized incidence rates (SIRs) and associated 95% confidence intervals (CIs) using the Danish national cancer rate to compare observed silver Cancer incidence and expected incidence in patients with psoriasis and VTE .
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Serum amyloid A to albumin ratio as a potential biomarker for predicting systemic lupus erythematosus activity, severity and poor prognosis
Time of Update: 2022-03-04
High SAR, high ACR, high TG, low C3 and positive anti-dsDNA were shown to be independent influencing factors of active SLE .
High SAR, high ACR, high TG, low C3 and positive anti-dsDNA were shown to be independent influencing factors of active SLE .
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Sulfasalazine Clinical Medication Guide
Time of Update: 2022-03-03
Ø Drink plenty of water, can be taken with sodium bicarbonate: the metabolite of sulfasalazine, acesulfame, has low solubility in partial acid urine, easy to precipitate crystals, mechanical stimulation to the kidneys, low back pain and hematuria, and even occur Urinary closure, etc.
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Typical imaging manifestations and pathophysiology of ankylosing spondylitis
Time of Update: 2022-03-03
It starts at the sacroiliac joint, with early destruction, space narrowing and subchondral bone sclerosis.
com ⒈ Early manifestations: generalized osteoporosis, difficult to diagnose, and poor prognosis ⒉ Sacroiliitis: ⒊ Spinal changes:MpZ Image Park XCTMR.
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Real hammer!
Time of Update: 2022-03-03
Another cross-sectional study of 867 patients with type 2 diabetes showed that serum uric acid levels were positively correlated with centrosome fat distribution, especially in visceral adipose tissue (r=0.
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NEJM: Tongue Necrosis in Giant Cell Arteritis
Time of Update: 2022-03-03
Tongue infarction is a rare complication of giant cell arteritis and should be considered in the differential diagnosis of tongue necrosis .
Vascular Diagnosis Tongue infarction is a rare complication of giant cell arteritis and should be considered in the differential diagnosis of tongue necrosis .
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Lancet Rheumatology: SARS-CoV-2 seropositivity in patients with autoimmune disease is even better for new crown vaccine
Time of Update: 2022-03-03
This study provides evidence that a single dose of CoronaVac may be sufficient to generate a strong antibody response in autoimmune rheumatic patients exposed to natural SARS-CoV-2 infection, whereas unexposed individuals require at least two doses .
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The Lancet Rheumatology: Predicting the Risk of Needing Total Knee Replacement
Time of Update: 2022-03-03
The most predictive factors associated with increased risk of total knee arthroplasty were older age, pain, and radiographic severity of osteoarthritis .
The most predictive factors associated with increased risk of total knee arthroplasty were older age, pain, and radiographic severity of osteoarthritis .
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Lancet Rheumatology: A new treatment for systemic sclerosis?
Time of Update: 2022-03-03
We aimed to test the safety and feasibility of a single intravenous injection of intrafamilial allogeneic bone marrow-derived mesenchymal stromal cells for the treatment of severe diffuse systemic sclerosis .
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Ann Rheum Dis: TNF inhibitor treatment in JIA children increases psoriasis incidence
Time of Update: 2022-03-02
CONCLUSIONS: In a large prospective cohort of patients with JIA, we observed a nearly three-fold increase in psoriasis risk following TNFi treatment .
In a large prospective cohort of JIA patients, the researchers observed a nearly three-fold increase in psoriasis risk following TNFi treatment .
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Pharmacol Res: GIP and GLP-2 together improve bone turnover in humans supporting GIPR-GLP-2R co-agonists as future osteoporosis treatments
Time of Update: 2022-02-19
The successful development of GIPR-GLP-2R co-agonists, coupled with the improved effect of co-administration on human bone metabolism, supports these co-agonists as future therapeutics for osteoporosis .
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"Coke bottle sign", what does this sign suggest?
Time of Update: 2022-02-19
2. The axial view can better show the thickening of the medial and lateral rectus muscles, the thin bone of the medial orbital wall, and the long-term increase in orbital pressure, which causes the ethmoid bone cardboard to concave in the arc of the ethmoid sinus, bilaterally symmetrical, like a "Coke bottle" sign .
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A&R: Induction of interferon-gamma and tissue inflammation by overexpression of eosinophil cationic protein in T cells and exosomes
Time of Update: 2022-02-19
RESULTS: We identified eosinophil cationic protein ( ECP , also known as human RNase III ) overexpressed in SLE T cell-derived exosomes .
RESULTS: We identified eosinophil cationic protein ( ECP , also known as human RNase III ) overexpressed in SLE T cell-derived exosomes .
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The Lancet: How much uric acid needs to be reduced to reduce gout attacks
Time of Update: 2022-02-19
Regarding this issue, the "American Association of Physicians Clinical Practice Guidelines : Management of Acute and Recurrent Gout " published in 2017 believes that most patients with gout for the first time, or patients with infrequent gout attacks, do not recommend long-term uric acid-lowering therapy .
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Imaging diagnosis of rheumatoid arthritis
Time of Update: 2022-02-19
How does aseptic inflammation affect the development of ankylosing spondylitis?2, pictures and texts!
How does aseptic inflammation affect the development of ankylosing spondylitis?3.
How does aseptic inflammation affect the development of ankylosing spondylitis?3.
The most complete diagnosis and treatment plan is here, hurry up and collect it!
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ARD: An imbalance between protective and pro-inflammatory synovial tissue T-cell versatility predates the clinical onset of rheumatoid arthritis
Time of Update: 2022-02-18
Objectives: This study investigates pathogenic and protective pluripotent T -cell responses in synovial tissue biopsies from rheumatoid arthritis (RA) , at-risk individuals (IAR), and healthy controls (HC) and to determine the time before clinical inflammation develops Presence of novel pathogenic pluripotent T cell populations enriched in RA joints .
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A&R: Duloxetine has no added value in patients with chronic pain from hip or knee osteoarthritis
Time of Update: 2022-02-18
This study evaluated the effectiveness of duloxetine added to the usual care of patients with chronic osteoarthritis (OA) pain .
This study evaluated the effectiveness of duloxetine added to the usual care of patients with chronic osteoarthritis (OA) pain .
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A&R: Variations in UBE2L3/YDJC autoimmune disease risk haplotypes increase UBE2L3 expression by modulating CCCTC-binding factor and YY1 binding
Time of Update: 2022-02-18
High-throughput sequencing of chromosome conformation capture combined with ChIP (HiChIP) and 3C-qPCR revealed a long-range interaction between the UBE2L3 promoter (rs140490 , rs140491 , rs11089620) and the downstream YDJC promoter (rs3747093 ) The /YDJC risk haplotype is enhanced and associated with loss of CCCTC- binding factor (CTCF) and increased YY1 binding on the risk allele .
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A&R: Magnetic Resonance Imaging for Evaluation of Subchondral Cysts and Sudden Knee Pain and Knee Osteoarthritis: Data from the Multicenter Osteoarthritis Study
Time of Update: 2022-02-18
Multiple logistic regression, adjusting for participant characteristics and other baseline knee MRI results, to assess whether subchondral cysts predict event outcomes .
Multiple logistic regression, adjusting for participant characteristics and other baseline knee MRI results, to assess whether subchondral cysts predict event outcomes .
