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A&R: Efficacy of a short-term bridging strategy with different doses of prednisolone on imaging and clinical outcomes in active early rheumatoid arthritis

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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Purpose: In active early rheumatoid arthritis (RA) , glucocorticoids are often used for bridging due to the delayed effects of methotrexa.

Methods: Adult RA patients with moderate / high disease activity from one rheumatology hospital and 23 rheumatology treatment centers were randomized (1:1:1) to 60 mg (high dose, HDP ) and 10 mg daily Prednisolone (low dose, LDP , tapering to 0 mg over 12 weeks ) or placeb.

RESULTS: Of 395 randomized patients ( n=132 high-dose group, n=131 low-dose group, n=132 placebo), 375 ( 95% ) remained in the modified intention-to-treat analys.

Conclusions: The results of this study showed that high-dose short-term glucocorticoid bridging (bridging) therapy did not have any benefit on the progression of radiographic damage in patients with rheumatoid arthritis within one ye.

Krause,.
, Mai,.
, Klaassen-Mielke,.
, et .
(2022), The efficacy of short-term bridging strategies with high- and low-dose prednisolone on radiographic and clinical outcomes in active early rheumatoid arthritis : a double-blind, randomized, placebo-controlled tri.
Arthritis Rheumat.
Accepted Author Manuscri.
https://d.
org/11002/a.
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