-
The pattern is open!
Time of Update: 2022-05-14
The hearing loss persisted , and the patient began to experience intermittent tinnitus in the left ear and red eyes .
The hearing loss persisted , and the patient began to experience intermittent tinnitus in the left ear and red eyes .
-
Arthritis Res Ther: TLC599 Treatment Provides Durable Pain Relief and Functional Improvement in Knee Osteoarthritis Patients
Time of Update: 2022-05-14
A randomized, double-blind, placebo-controlled study published in Arthritis Res Ther evaluated the efficacy and safety of TLC599 at two dose levels in patients with knee osteoarthritis .
, TLC599 in patients with osteoarthritis of the knee: a phase IIa, randomized, placebo-controlled, dose-finding study .
-
A&R: 2021 American College of Rheumatology/Vgiitis Foundation Guidelines for the Management of Kawasaki Disease
Time of Update: 2022-05-14
The purpose of this guideline is to provide evidence-based recommendations and expert guidance for the management of Kawasaki disease (KD) , focusing on clinical situations that rheumatologists often encounter and require management .
-
J Dermatolog Treat: Analysis of Disease Activity and Treatment Effects Using Patient-Level Psoriasis Area and Severity Index Scores in Phase 3 Clinical Trials
Time of Update: 2022-05-14
RESULTS: The median baseline Psoriasis Area and Severity Index (PASI) was 17.
, Disease activity and treatment efficacy using patient-level Psoriasis Area and Severity Index scores from tildrakizumab phase 3 clinical trials.
-
Stem Cell Res Ther: Mesenchymal Stem Cells or Effective Therapy for Systemic Sclerosis
Time of Update: 2022-05-14
Taken together, the results of this study show that mesenchymal stem cell therapy can improve skin thickening, lung function, and mouth opening in patients with SSc, and relieve finger ulcers and pain without serious adverse events .
-
Lancet Rheumatolgoy: Safety and preliminary efficacy of allogeneic bone marrow-derived pluripotent mesenchymal stromal cells in the treatment of systemic sclerosis
Time of Update: 2022-05-14
This study was designed to test the safety and feasibility of a single intravenous injection of familial allogeneic bone marrow-derived mesenchymal stromal cells in the treatment of severe diffuse systemic sclerosis .
-
From 3 major aspects, look at the pain management of rheumatoid arthritis
Time of Update: 2022-05-14
Non-steroidal anti-inflammatory drugs (NSAIDs): they are the most well-documented and commonly used analgesics, and the first choice for pain treatment in patients with RA .
Non-steroidal anti-inflammatory drugs (NSAIDs): they are the most well-documented and commonly used analgesics, and the first choice for pain treatment in patients with RA .
-
How to diagnose and treat pulmonary hypertension associated with connective tissue disease?
Time of Update: 2022-05-14
Diagnosis and treatment guidelines Chinese Medical Association Rheumatology Branch Diagnosis and treatment of connective tissue disease-related pulmonary hypertension01 Diagnostic criteria for CTD-PAH01 Diagnostic criteria for CTD-PAH Diagnostic criteria for CTD-PAHFor patients suspected of CTD-PAH, after initial screening to support the diagnosis of PAH, right heart catheterization (RHC) should be completed as soon as possible, and if necessary, pulmonary function, pulmonary ventilation perfusion imaging, CT pulmonary angiography and other tests should be completed for accurate diagnosis and classification (see Fig.
-
Biomed Pharmacother: Protective effect of Yangxuejiedu decoction on psoriasis-like lesions by regulating TLR4/NF-κB signaling pathway mediated by exosomal HSP70 secretion
Time of Update: 2022-05-14
Background: Psoriasis is a common chronic inflammatory proliferative skin disease characterized by abnormal proliferation and differentiation of keratinocytes and immune T cells . The pathogenesis o
-
Lancet Rheumatology: Comparison of mixed immunity (infection + vaccine) and vaccine-induced immunity against SARS-CoV-2 in patients with autoimmune rheumatism
Time of Update: 2022-05-14
Researchers identified 30 patients registered at the Arthritis and Rheumatology Centre of Excellence in Cochin, India, who were infected with SARS-CoV-2 between August 2020 and July 2021 and received a serial dose of ChAdOx1 vaccine (infection plus vaccine).
-
Interpretation of ANCA indicators in the Department of Rheumatology and Immunology
Time of Update: 2022-05-14
Immunofluorescence is more sensitive and can distinguish C-ANCA from P-ANCA ELISA is more specific and can be seen to detect PR3 and MPO antibodiesIn the indirect immunofluorescence assay of ANCA, when serum from patients with ANCA-associated vasculitis was incubated with ethanol-fixed human neutrophils, there were two fluorescence patterns, namely:●C-ANCA mode – For the cytoplasmic ANCA (C-ANCA) mode, the staining is diffuse throughout the cytoplasm .
-
A&R: 2021 American College of Rheumatology Guidelines for the Treatment of Juvenile Idiopathic Arthritis: Nonpharmacological Treatment, Drug Monitoring, Immunization, and Imaging Recommendations
Time of Update: 2022-05-14
(2022), 2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.
(2022), 2021 American College of Rheumatology Guideline for the Treatment of Juvenile Idiopathic Arthritis: Recommendations for Nonpharmacologic Therapies, Medication Monitoring, Immunizations, and Imaging.
-
JEADV: Prevalence and characteristics of refractory psoriasis and super-response to biological therapy
Time of Update: 2022-05-14
Identify and describe patients with treatment-refractory psoriasis and those who have had a significant response to biological therapy .
Super responders were defined as patients with a psoriasis area and severity index (PASI) >3 within at least 5 years of the first biologic therapy between 6 months and 5 years of treatment .
-
8 pictures summarize the pathogenesis of RA, worthy of collection
Time of Update: 2022-05-14
RASFs: rheumatoid arthritis synovial fibroblasts, PBMCs: peripheral blood mononuclear cells, Th17: T-helper 17 cells, Tregs: T-regulatory cells, MMPs: matrix metalloproteinases, NF-κB: nuclear factor κβ, TLR: toll-like receptor, JAK/STAT: Janus kinase/activator of signaling and transcriptional proteins
-
Biomolecules: Do placebo-related adverse events occur in rheumatoid arthritis?
Time of Update: 2022-05-14
Rheumatoid arthritis (RA) patients should rapidly achieve remission, or at least low disease activity, to avoid joint destruction that can lead to severe disability and premature death, according to the "Fit the Right Medicine" initiative .
-
Lancet rheumatology: STAR pathway of care in patients with pain 3 months after total knee arthroplasty: a multicenter, pragmatic, randomized, controlled trial
Time of Update: 2022-05-14
Patients with chronic pain 3 months after total knee replacement surgery were randomly assigned (2:1) to receive the Post Replacement Support and Therapy (STAR) pathway of care plus usual care, or to receive usual care alone .
-
J Nanobiotechnology: Multifunctional composite hydrogels as endogenous and exogenous synergistic modulators enhance efficacy in psoriasis
Time of Update: 2022-05-14
Experiments show that zinc oxide/silver nanoparticles can inhibit the secretion of adaptive cytokines in KCs by inhibiting the activation of p65 in pro-inflammatory macrophages and by downregulating the ROS-mediated STAT3-Cyclin D1 signaling pathway, thereby reducing intrinsic cytokine profile, thereby exerting a self-healing effect .
-
Science Advances: Massachusetts General Hospital discovers the regulation mechanism of natural killer (NK) cell function, bringing new opportunities for the treatment of cancer, autoimmunity and other diseases
Time of Update: 2022-05-14
A new study from Massachusetts General Hospital reveals the interaction between affecting natural killer (NK) cells -- which are part of the body's innate or first-line immune response -- and tumor cells, viral infections and solid organ transplantation.
-
Development and initial validation of the Sjögren's Syndrome Response Assessment Tool (STAR): a composite score for assessing treatment effects in primary Sjögren's syndrome
Time of Update: 2022-05-14
The NECESSITY (New Clinical Endpoints in Primary Sjögren's Syndrome: Interventional Trials Based on Patient Stratification) Consortium (https:// includes pSS experts from academia, pharmaceutical industry and patient groups, The experts aimed to develop a new composite responder index, Sjögren's Response Assessment Tool (STAR) .
-
4.20 International Gout Day, answer 7 questions about gout at one time
Time of Update: 2022-05-14
Similarly, for people who already suffer from gout, a low-purine diet has very limited changes in blood uric acid levels .
Similarly, for people who already suffer from gout, a low-purine diet has very limited changes in blood uric acid levels .
