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Ann Rheum Dis: Use it with confidence!
Time of Update: 2022-05-14
A meta-analysis published in Ann Rheum Dis reports the long-term safety of baricitinib, an oral selective Janus kinase inhibitor, in patients with active rheumatoid arthritis (RA) .
Results of the analysis showed baricitinib incidence rates (IRs) per 100 patient-years for serious infections, herpes zoster, and major adverse cardiovascular events (MACE) of 2.
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Five types of knee arthritis that are easy to confuse, finally understand
Time of Update: 2022-05-14
Most of the patients suffer from middle-aged and elderly people, and their symptoms are mostly manifested as knee swelling and pain, pain when going up and down stairs, and knee pain and discomfort when sitting, standing, and walking .
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Science Advances: Massachusetts General Hospital discovers the regulation mechanism of natural killer (NK) cell function, bringing new opportunities for the treatment of cancer, autoimmunity and other diseases
Time of Update: 2022-05-14
A new study from Massachusetts General Hospital reveals the interaction between affecting natural killer (NK) cells -- which are part of the body's innate or first-line immune response -- and tumor cells, viral infections and solid organ transplantation.
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A&R: Association between gut microbiota and elevated serum uric acid in two independent cohorts
Time of Update: 2022-05-13
e. , the richness, diversity, composition, and relative abundance of microbial communities) and predicts functional pathways leading to hyperuricemia and serum urate levels .
e. , the richness, diversity, composition, and relative abundance of microbial communities) and predicts functional pathways leading to hyperuricemia and serum urate levels .
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A&R: Recreational Physical Activity and Risk of Knee Osteoarthritis: An International Meta-Analysis of Individual Participant Data
Time of Update: 2022-05-13
RESULTS: Based on a total of 5065 participants, the pooled RR estimated the association of MET days per week with painful radiological OA ( RR 1.
Based on a total of 5065 participants, the pooled RR estimated the association of MET days per week with painful radiological OA ( RR 1.
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A&R: Impact of impaired T-cell receptor signaling on gut microbiota in a mouse model of systemic autoimmunity
Time of Update: 2022-05-13
B6SKG mice had altered gut microbiota that was associated with the expansion of segmented filamentous bacteria and the development of SLE by driving Th17 cell differentiation , which in turn was impaired by IL-17 deficiency .
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Beauty is not only on the face!
Time of Update: 2022-05-03
The answer to why the human perception system considers some people's physical characteristics more attractive than others is undoubtedly complex, involving age, gender, culture, and individual characteristics .
Therefore, further research is needed to replicate these results and explore what drives the link between physical attractiveness and immune function .
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"Science": Eat 80% full, immunity is not afraid of old age!
Time of Update: 2022-05-02
After analyzing data from 218 healthy individuals with up to 2 years of follow-up, the researchers proposed that a 14% reduction in long-term caloric intake could rejuvenate the thymus, an important immune organ, and increase the thymus' ability to produce T cells, thereby improving the A phenomenon in which immune function declines with age .
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【Science】Immune cells that have been underestimated: marginal zone B cells, cannibalize similar functions, resist various infections, and enhance immune responses!
Time of Update: 2022-05-02
" said Justine Mintern, associate professor at the University of Melbourne, laboratory leader at the Bio21 Institute, and co-author of the research paper, MZ B cells are thought to have a limited contribution to immune defence because they appear to be incapable of carrying out some key functions .
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Adv. Sci., Research Group of Cheng Jixin, Boston University, USA: A new strategy against drug-resistant fungi: Inactivation of catalase by blue light to combat drug-resistant fungi and super fungi
Time of Update: 2022-05-02
At the same time, the research group found that a week of continuous synergistic therapy against Candida albicans (blue light light plus low-concentration hydrogen peroxide) did not make Candida albicans resistant, and the catalase in Candida albicans was not effective.
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Nat Commun Zhu Ping's team found that TNF antagonists combined with ferroptosis inducers alleviate the progression of rheumatoid arthritis
Time of Update: 2022-05-02
Recently, the team of Professor Zhu Ping, Department of Clinical Immunology, Xijing Hospital, Air Force Military Medical University published a research work entitled TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models in the journal Nature Communications, and found that in the progression of rheumatoid arthritis , tumor necrosis factor TNF is a key signal regulating the resistance to ferroptosis in synovial fibroblasts .
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Homologous booster immunization can induce the production of cross-neutralizing antibodies against 2019-nCoV variants
Time of Update: 2022-05-02
Focusing on this problem, the new crown epidemic research team of the Institute of Medical Laboratory Animals, Chinese Academy of Medical Sciences immediately carried out research on whether homologous immunity of vaccines has a cross-protective effect on mutant strains .
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Science highlights calorie-restricted diets promote longevity and new evidence - boosts immune system function
Time of Update: 2022-05-02
AuthorHu Xiaohua Caloric Restriction (CR) diet can promote longevity, but studies in mice have found that reducing calorie intake by 40% can extend the life of mice, but the risk of virus and parasite infection It will also increase, and researchers have found that this side effect may be due to impaired immune function [1] .
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Sci Adv｜Dr. Wen Bijun et al. report the control of systemic inflammation and metabolic disorders in severely malnourished children
Time of Update: 2022-05-02
Overall, this study found that disturbances in systemic immunity and mitochondrial energy metabolism were associated with survival outcomes in severely malnourished hospitalized children through multi-omics analysis .
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PCE Jiangsu Academy of Agricultural Sciences Zhou Tong's team and Cornell University Huajian team cooperated to discover the transcriptional regulation mechanism of plant intracellular immune receptor genes
Time of Update: 2022-05-02
Recently, researcher Zhou Tong's research group from the Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences and Professor Hua Jian's research group from Cornell University published a paper entitled "In situ deletions reveal regulatory components for expression of an intracellular immune receptor gene" on Plant, Cell & Environment.
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The research group of Tang Dingzhong from Fujian Agriculture and Forestry University revealed the mechanism of rice 14-3-3 regulating the immune response mediated by GRAS protein OsSCL7
Time of Update: 2022-05-02
This study clarifies that the rice 14-3-3 protein GF14c affects the rice blast resistance by regulating the stability of OsSCL7 in plants, providing new clues for understanding how GRAS protein participates in plant immune regulation .
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Cover of Journal of Virology: Viral disease advances in immune function and structure of African swine fever T-cell epitopes
Time of Update: 2022-05-02
Recently, Liu Jun, a researcher and collaborators from the Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, published a cover article entitled "Mooring stone-like Arg114 pullsdiverse bulged peptides: first insight into African swine fever virus" in the Journal of Virology.
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Understanding individual differences in immune function, new study finds key differences in these T cells
Time of Update: 2022-05-02
▲ The effect of many common genetic variants on gene expression is only strongly expressed in specific types of cells, after the cells are activated (Image source: Reference [1]) The results of the study also found that the way helper T cells work is affected by biological Significant impact of gender .
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【Cell Sub-issue】Breakthrough!
Time of Update: 2022-05-02
Researchers from the Center for Physiology and Pharmacology at the Medical University of Vienna have discovered an important signaling pathway in immune cells, a discovery that could lead to the development of a new approach to the treatment of autoimmune diseases .
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Yuan Zhenghong's team from Fudan University reveals a new mechanism by which hepatitis B virus induces immune tolerance by regulating CD8+ T cell thymus development
Time of Update: 2022-05-01
Recently, Yuan Zhenghong's team from the Department of Pathogenic Biology and the Key Laboratory of Medical Molecular Virology, Ministry of Education/Health and Health Commission, Fudan University School of Basic Medicine, published an online publication in the Journal of Experimental Medicine entitled: Monocytic MDSCs homing to thymus contribute to age-related Research paper on CD8+ T cell tolerance of HBV .
