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Nat Immunol Xue Haihui/Zang Chongzhi's team discovered the important regulatory role of Tcf1 transcription factor in T cell immune memory and secondary immune response
Time of Update: 2022-05-01
On February 21, 2022, the team of Professor Haihui Xue from Hackensack University Medical Center and the team of Professor Zang Chongzhi from the University of Virginia jointly published a paper entitled Tcf1 preprograms the mobilization of glycolysis in Nature Immunology The research paper in central memory CD8+ T cells during recall responses revealed the mechanism by which transcription factor Tcf1 regulates gene transcription during the secondary immune response of a memory immune cell.
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Nature sub-published Air Force Military Medical University Zhu Ping/Chen Zhinan/Wu Jiao et al reveal the potential mechanism of TNF antagonists combined with ferroptosis inducers to alleviate rheumatoid arthritis
Time of Update: 2022-05-01
Finally, in the CIA model, low-dose IKE combined with the TNF antagonist etanercept induced fibroblast ferroptosis and delayed arthritis progression .
In the CIA model, the combination of a TNF antagonist and a low-dose ferroptosis inducer induces ferroptosis in synovial fibroblasts and significantly slows the progression of arthritis .
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Nature highlights lung microbiota targets brain microglia to suppress autoimmune diseases
Time of Update: 2022-05-01
Therefore, the authors detected the EAE of the central nervous system and found that the degree of disease in the neomycin-treated group was significantly reduced, especially when the adoptive T cell EAE method was used to model the changes .
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PNAS Wuhan University Li Shu/Shu Hongbing discovered the regulation mechanism of interleukin 33 receptor-mediated inflammatory response and pulmonary fibrosis
Time of Update: 2022-05-01
Taken together, our findings demonstrate that K27-related polyubiquitination and deubiquitination of IL-33R by TRAF6 and USP38 reciprocally regulate IL-33R levels and signaling, which represents the modulation of IL-33-triggered pneumonia responses and lung Key Mechanisms of Fibrosis.
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Professor Chen Qijun's research group revealed that dihydroartemisinin regulates spleen immune cell heterogeneity through SOD3-JNK-AP-1 signaling pathway
Time of Update: 2022-05-01
Recently, Professor Chen Qijun's research group from Shenyang Agricultural University published a research paper entitled "Dihydroartemisinin beneficially regulates splenic immune cell heterogeneity through the SOD3-JNK-AP-1 axis" in Science China Life Sciences, revealing that DHA regulates SOD3-JNK- AP-1 signaling pathway regulates the body's immune system .
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"The man who defeated AIDS" He Dayi published a Nature paper, revealing the antibody evasion properties of Omicron
Time of Update: 2022-05-01
In this study, several VOCs were examined, including Alpha, Beta, Gamma, Delta, and Omicron, and it was demonstrated that the Omicron variant RBD binds hACE2 with comparable affinity to the prototype .
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Advanced Science Zhong Bo/Lin Dandan of Wuhan University reveal the important role of IL-36γ and IL-36Ra in regulating colonic inflammation and tumorigenesis
Time of Update: 2022-05-01
On February 4, 2022, Zhong Bo and Lin Dandan of Wuhan University jointly published a research titled "IL-36γ and IL-36Ra Reciprocally Regulate Colon Inflammation and Tumorigenesis by Modulating the Cell-Matrix Adhesion Network and Wnt Signaling" in the journal Advanced Science In the paper, this study shows that IL-36γ and IL-36Ra act as agonists and antagonists of IL-36R signaling, respectively, and have a reciprocal regulatory effect on the development of experimental colitis and colon cancer in mice .
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Anticancer mechanism of Immunity immune checkpoint protein PD-1 and TIGIT co-blocking therapy
Time of Update: 2022-05-01
Chiang's team from Genentech and Huinf's team from UC San Diego published in Immunity magazine Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates Research paper on co-blockade to optimize anti-tumor CD8+ T cell responses .
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The research group of Academician Dong Chen reports that the plasticity of Tfh cells regulates the production of antiviral neutralizing antibodies
Time of Update: 2022-04-30
The new academician column of Science China Life Sciences (FROM CAS & CAE MEMBERS) recently published a research article titled "Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity" by the research group of Academician Dong Chen from the Institute of Immunology, Tsinghua University.
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Express reduces key indicators of gout, and the Phase 2a clinical results of oral innovative drugs are positive
Time of Update: 2022-04-30
The trial met the primary endpoint of reducing patients' serum uric acid (sUA) levels to below 6 mg/dL (below the clinically defined hyperuricemia threshold of 7 mg/dL) .
” Reference: [1] Atom Bioscience Announces Positive Phase 2a Results For Investigational New Drug to Treat Chronic Gout.
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No drug is effective, why is this type of RA so "refractory"?
Time of Update: 2022-04-30
In patients treated with tumor necrosis factor inhibitors (TNFi), the expression levels of genes associated with innate immune cells were higher in responders at baseline and those associated with adaptive immune cells were higher in non-responders high .
In a study of patients treated with TNFi, high baseline levels of IL-17A-producing Th17 cells were associated with non-response.
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Positive selection maturation mechanism of germinal center B cells in Sci Immunol
Time of Update: 2022-04-30
A more popular model over the past 25 years is that germinal center B cells require affinity-based competition for cyclic reentry each time they enter the bright zone .
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Plant Cell Innate Defense Is Now: Plant Cell Membrane Nanodomains Assist Actin Remodeling
Time of Update: 2022-04-30
We found in previous studies that bacterial-induced plant innate immunity induces macromolecular aggregation of formin proteins on the plant cell surface to form nanoscale molecular clusters, thereby activating the activity of formin proteins to act on actin polymerization .
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Which symptom does a 53-year-old female rheumatoid arthritis patient not have?
Time of Update: 2022-04-30
X-ray shows narrowing of sacroiliac joint space D.
X-ray films showed proximal interphalangeal joint space stenosis.
Link to the previous article: A 30-year-old female patient with elevated white blood cells in the joint effusion and positive HLA-B27.
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[Cell Sub-issue] Fine-tune antibodies to achieve the best anti-infection effect!
Time of Update: 2022-04-30
The process of selecting the best antibodies occurs in the germinal center, and for vaccines to be more effective and durable, scientists need to better understand this important location and the process of how they evolved .
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Finally waiting for you｜After 4 years, the latest version of the WAO/EAACI HAE guide is updated
Time of Update: 2022-04-30
New recommendations for the update of long-term preventive treatment of HAE: The goal of HAE treatment is to control the disease as a whole and normalize the life of patients.
New first-line drugs for long-term preventive treatment The previous guidelines only recommended C1-INH as first-line treatment .
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How did this patient get a new lease of life after being "entangled" with rheumatoid arthritis for many years?
Time of Update: 2022-04-30
During tocilizumab treatment, inflammatory markers were poorly controlled, and ESR and CRP levels decreased significantly after switching to abatacept (Figure 3) .
Efficacy of Abatacept and Adalimumab in Patients with Early Rheumatoid Arthritis With Multiple Poor Prognostic Factors: Post Hoc Analysis of a Randomized Controlled Clinical Trial (AMPLE) [J].
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JCI Liu Wanli/Shen Zhanlong collaborated to discover the anti-tumor effect of IgG1 memory B cell antigen receptor variants
Time of Update: 2022-04-30
Based on this, Professor Liu Wanli's research group and Professor Shen Zhanlong's research group worked together to conduct epidemiological analysis on a cohort of more than 1,000 colorectal cancer patients with ten-year follow-up information in the Department of Gastrointestinal Surgery of Peking University People's Hospital, and found that hIgG1-G396R homozygous Genotype tumor patients had significantly improved overall survival (OS, HR=0.
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Repeated pleural effusion is not good, it may be caused by gout
Time of Update: 2022-04-30
Figure B, C VAST examination combined with the patient's symptoms, blood uric acid results, pathological results, the final diagnosis of gouty lung damage .
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Diagnosis and treatment of systemic lupus erythematosus in children, the latest guidelines recommend a list!
Time of Update: 2022-04-30
Immunosuppressive therapy The use of immunosuppressive agents should be comprehensively considered according to the organ involvement, disease activity and drug safety in children with SLE (1C) .
Risk factors for concurrent infection in children with SLE include increased disease activity, immunosuppressive therapy, high-dose corticosteroids, multiple organ involvement, and prolonged hospital stay (1C) .
