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A 30-year-old female patient with elevated leukocytes in the joint effusion and positive HLA-B27, what diagnosis should be considered?
Time of Update: 2022-04-30
Rheumatoid arthritis Previous answer: A Analysis: ① Middle-aged woman, the patient presented with multisystem manifestations Such as oral cavity (stomatitis), skin (congestive erythema), musculoskeletal system (facet joint tenderness), urinary system (proteinuria), blood system (cytopenia) and other lesions, of which the characteristic lesions are facial erythema, combined with patient resistance SSA antibody (+) and anti-double-stranded DNA antibody (+), it can be diagnosed as systemic lupus erythematosus .
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Oral VS subcutaneous injection, application of "methotrexate" should pay attention to these problems!
Time of Update: 2022-04-30
Recently, an article published in Rheumatology investigated this issue, which specifically tested the cumulative recurrence rate after 1 year in RA patients treated with oral MTX and MTXsc [5] .
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Sudden septic shock in rheumatism patients is actually related to acupuncture?
Time of Update: 2022-04-30
The differential diagnosis should not forget that the patient presented with fever, right lower neck pain, and progressive swelling of the right upper extremity, but no erythema, which is similar to the symptoms of deep vein thrombosis, and also needs to be differentially diagnosed with lymphangitis .
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JCI Liu Wanli/Shen Zhanlong collaborated to discover the anti-tumor effect of IgG1 memory B cell antigen receptor variants
Time of Update: 2022-04-30
Based on this, Professor Liu Wanli's research group and Professor Shen Zhanlong's research group worked together to conduct epidemiological analysis on a cohort of more than 1,000 colorectal cancer patients with ten-year follow-up information in the Department of Gastrointestinal Surgery of Peking University People's Hospital, and found that hIgG1-G396R homozygous Genotype tumor patients had significantly improved overall survival (OS, HR=0.
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Dry eyes, sore eyes, uncomfortable eyes, be careful of these rheumatic immune diseases
Time of Update: 2022-04-30
There are other rheumatic immune diseases, such as relapsing polychondritis, which affects about half of the patients' eyes; juvenile rheumatoid arthritis can also cause inflammation of the iris and ciliary body of the eye .
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A new oral drug for systemic lupus erythematosus?
Time of Update: 2022-04-30
On March 10, 2022, the New England Journal of Medicine (NEJM) published a phase 2 randomized, placebo-controlled, double-blind trial at 117 sites in multiple countries evaluating 3 doses of ibedox Efficacy of amines in patients with moderate to severe SLE .
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NEJM sub-issue: Allopurinol VS Febuxostat, who is better?
Time of Update: 2022-04-30
Methods: In this 72-week trial, participants with gout and hyperuricemia [at least 33% with stage 3 chronic kidney disease (CKD)] were randomly assigned to allopurinol or febuxostat In the treatment group, the dose was titrated to achieve the target serum urate level .
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2021 Roundup Recommended by Trends in Immunology Editors
Time of Update: 2022-04-30
Scan to browse Trends in Immunology's editor-recommended 2021 roundup T cells: warriors against SARS-CoV-2 infection release and T cell death .
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Nat Immunol︱Daily maintenance, a new mechanism for tissue monitoring under local T cell homeostasis
Time of Update: 2022-04-30
Article | Sister Xian For a long time, people's role of the immune system has been limited to anti-infection and anti-tumor protection. It is believed that the steady-state immune system has always
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"Myocardial infarction" is because of this rheumatism, 90% of doctors have never seen it!
Time of Update: 2022-04-29
Preliminary diagnosis: Combined with symptoms and medical history, the doctor considered that the patient was most likely to have ACS or even myocardial infarction, but the electrocardiogram showed acute myopericarditis, but TTE did not show myocardial abnormality .
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Cell sub-issue: Qiu Ju's team discovered the regulatory role of Setd2 on type 3 innate lymphocytes and intestinal immunity
Time of Update: 2022-04-29
Recently, the international academic journal Cell Reports published online the latest research results titled "Setd2 determines distinct properties of intestinal ILC3 subsets to regulate intestinal immunity" by Qiu Ju's research group from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences .
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Female patients with anemia and positive anti-double-stranded DNA antibodies, what is the drug of choice for treatment?
Time of Update: 2022-04-29
Link to the previous article: 53-year-old female rheumatoid arthritis patient, which symptom does not appear?
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A 54-year-old female patient with rheumatoid arthritis. What are the basic features of the lesion?
Time of Update: 2022-04-29
Ligamentitis Upper stage Answer: C Interpretation: Rheumatic diseases include diffuse connective tissue diseases such as rheumatoid arthritis , Systemic lupus erythematosus, primary Sjögren's syndrome, polymyositis/dermatomyositis, systemic sclerosis, systemic vasculitis, etc.
Link to the previous article: Which of these diseases is not a connective tissue disease?
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Nature sub-issue: Chinese Academy of Sciences Yang Weiwei team discovered a new mechanism of tumor immune escape
Time of Update: 2022-04-29
On March 21, 2022, Yang Weiwei's research group from the Center for Excellence in Molecular and Cellular Science, Chinese Academy of Sciences, together with Researcher Zhao Yun and Yao Feng, Deputy Chief Physician of the Chest Hospital Affiliated to Shanghai Jiaotong University, published a paper in the journal Nature Metabolism entitled: MAPK signalling-induced phosphorylation and Research paper on subcellular translocation of PDHE1α promotes tumor immune evasion .
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Does the popular "gluten-free diet" really work for people with rheumatism?
Time of Update: 2022-04-29
Studies have shown that people with psoriatic arthritis are more likely to develop celiac disease and may benefit from a gluten-free diet, but the sample size it collected was limited and informative .
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[Cell Sub-issue] High sugar does promote inflammation!
Time of Update: 2022-04-29
"Väth and his team demonstrated that a special glucose transporter scientifically named GLUT3 performs additional metabolic functions in T cells in addition to producing energy from sugar .
T cell "metabolic reprogramming" offers new possibilities for the treatment of autoimmune diseases without Impairs the function of protective immune cells .
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Identification, immune activation and signal regulation of plant NLR immune receptors
Time of Update: 2022-04-29
1 After immune execution CNL-type NLRs recognize effector proteins, oligomeric ZAR1 disease-resistant bodies bind to PM and form cation-selective channels for calcium permeation, leading to calcium influx and further activation Downstream defense responses, including cell death, etc.
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An 'unexpected' case of gout
Time of Update: 2022-04-29
Combined medical history diagnosis: bilateral biceps multiple crystal deposits (gout); left biceps long head tendon hydrocele (inflammation) .
Just like this patient, who has always mistaken himself for a muscle strain, but ignored the harm of high uric acid .
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Which of these diseases is not a connective tissue disease?
Time of Update: 2022-04-29
The most commonly used prednisone, the dose is 1 mg per kilogram of body weight per day, the dose can be doubled in severe cases, and 0.
Link to previous article: Female patients with anemia and positive anti-double-stranded DNA antibodies, what is the preferred drug for treatment?
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Can't understand the common indicators of rheumatology?
Time of Update: 2022-04-29
That is to say, if the level of anti-ds-DNA antibodies is high, then the diagnosis of SLE is more likely, and this indicator can also detect disease activity!
