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Immunity is making further progress!
Time of Update: 2022-04-29
Tuft-2 cells highly express VR Vmn2r26, which senses the bacterial metabolite N-undecanoylglycine (N-C11-G), leading to the production of prostaglandin D2 (PGD2) to promote mucus secretion from goblet cells to fight bacteria infection .
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Dry mouth is Sjogren's syndrome?
Time of Update: 2022-04-29
*For medical professionals only, what should patients with Sjögren's syndrome pay attention to in their daily life?
Patients with primary Sjögren's syndrome with skin lesions should be debridement and dressings changed according to the skin lesions, and antibiotics can be used appropriately in case of infection .
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Nature Review: Four strategies to transform IL-2 for the treatment of cancer and autoimmune diseases
Time of Update: 2022-04-29
▲Introduction to SAR444245 (Image source: Sanofi official website) IL-2 immune complex IL-2 combined with anti-IL-2 monoclonal antibody to form a complex also prolongs the half-life of IL-2 protein and regulates the receptor binding selection of IL-2 a way of sex .
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Which of these diseases is not a connective tissue disease?
Time of Update: 2022-04-29
The most commonly used prednisone, the dose is 1 mg per kilogram of body weight per day, the dose can be doubled in severe cases, and 0.
Link to previous article: Female patients with anemia and positive anti-double-stranded DNA antibodies, what is the preferred drug for treatment?
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Another frontier progress in cellular immunotherapy: the first CAR-Treg therapy has been administered to patients Yimaimeng broke the news
Time of Update: 2022-04-28
TX200 is the company's wholly-owned autologous chimeric antigen receptor-regulated T cell (CAR-Treg) cell therapy candidate for the prevention of immune rejection following HLA-A2-mismatched living-donor kidney transplantation .
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Prof. Leng Xiaomei: If the "anchoring drugs" for RA treatment does not work, what traditional synthetic drugs are available?
Time of Update: 2022-04-28
Safety and efficacy of combination therapy of iguratimod with methotrexate for patients with active rheumatoid arthritis with an inadequate response to methotrexate: an open-label extension of a randomized, double-blind, placebo-controlled trial[J].
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Latest Research Express!
Time of Update: 2022-04-28
561), published the titles "Sirolimus Monotherapy for Thrombocytopenia in Primary Antiphospholipid Syndrome: A Pilot Study From a Tertiary Referral Center" and "Incidence of and Risk Factors for Paradoxical Psoriasis or Psoriasiform Lesions in Inflammatory Bowel Disease Patients Receiving Anti-TNF Therapy" : Systematic Review With Meta-Analysis" .
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Which undifferentiated arthritis progresses to RA?
Time of Update: 2022-04-28
Conclusions: This large prospective study suggests that MRI is most valuable in ACPA-negative UA patients with oligoarthritis; MRI-negative (without osteitis, synovitis, or tenosynovitis) helps prevent overtreatment .
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Jimin Trusted lgE antibody drug IND approved by CDE
Time of Update: 2022-04-28
Jimin Trust Group announced that the new drug clinical trial application (IND) submitted by its subsidiary Jiangsu Jiye Biopharmaceutical Co.
for a new anti-IgE recombinant humanized monoclonal antibody targeted therapy drug JYB1904 injection has been approved by the National Medical Products Administration of China.
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Which of these drugs is a non-selective COX inhibitor with strong analgesic effect?
Time of Update: 2022-04-28
② Most of the joint X-ray films are normal (D wrong), so D is selected for this question .
Link to previous article: Which of these manifestations is wrong about joint lesions in lupus patients?
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Fever + rash, the elderly have common diseases in children, be careful that cancer is at work!
Time of Update: 2022-04-28
However, both patients also had manifestations other than the typical symptoms of gastrointestinal tumors, such as: high fever, rash, diffuse congestion of the oral mucosa, conjunctivitis, and nonsuppurative lymphadenopathy .
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Nature｜Li Xin et al reveal the strain-specific effect of gut fungi on inflammatory bowel disease
Time of Update: 2022-04-28
albicans in the human colon to immune cells and the ability to induce pro-inflammatory responses such as TH17 in the mouse gut are strain-specific .
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From "total baldness" to regenerate 80% of hair!
Time of Update: 2022-04-28
In the new study, researchers conducted two large randomized, placebo-controlled Phase 3 trials involving a total of 1,200 adult patients with severe alopecia areata who had lost at least half their scalp and many had lost their hair completely .
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Cell's novel immune adjuvant mannan
Time of Update: 2022-04-28
The C-type lectin receptors (CLRs) Dectin-1 and Dectin-2 in the PRR can recognize the cell wall polysaccharides β-glucan and mannose to regulate innate and adaptive immune responses in fungal infections .
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Eyes are always uncomfortable, beware of these 5 common rheumatism!
Time of Update: 2022-04-28
. Ocular lesions of Behcet's disease can be manifested as anterior uveitis, posterior uveitis, retinal vasculitis, empyema, secondary glaucoma, cataract, visual loss and iris adhesion, which mostly occur within 3 years of onset , both eyes can be involved, the most common damage is uveitis, and the blindness rate is as high as 14.
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Unique biomarker for lupus nephritis discovered?
Time of Update: 2022-04-27
At present, no biomarkers with predictive value for the development of LN disease have been found for the time being, and more direct assessment of renal function is used to understand the damage to the kidneys caused by lupus erythematosus (SLE) .
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How to properly use glucocorticoids in patients with rheumatism?
Time of Update: 2022-04-27
*For medical professionals only for reference Serious adverse reactions caused by glucocorticoids are one of the causes of death in patients with rheumatic immune diseases.
Some patients also use short-acting and long-acting glucocorticoids to treat rheumatic immune diseases .
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With these risk factors, family members of rigid patients should be careful!
Time of Update: 2022-04-27
A study from Annals of Rheumatology followed up for 35 years and analyzed HLA-B27 levels, radiographic sacroiliitis status, clinical history including chronic inflammatory back pain (CIBP), acute anterior uveitis (AAU) and many other factors to predict its value for the development of axSpA .
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These incurable diseases may be a special type of rheumatoid arthritis!
Time of Update: 2022-04-27
The diagnosis of typical rheumatoid arthritis is not difficult, but some special types are often regarded as intractable diseases due to the lack of awareness of patients and even some doctors, which leads to detours in diagnosis and treatment, and even delays the disease.
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5 kinds of common arthritis foolishly confused?
Time of Update: 2022-04-27
The former is the degenerative changes to articular cartilage caused by factors such as heredity, age, obesity, injury, and overuse, which is our traditional understanding of OA; the latter refers to a chronic low-level inflammatory disease involving innate immunity.
