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This article was originally written by Translational Medicine Network.
Please indicate the source when reprinting
.
In people with autoimmune diseases, the immune system attacks the body's own tissues, such as chronic inflammatory bowel disease (such as Crohn's disease and ulcerative colitis), type 1 diabetes, and chronic inflammation of the thyroid
.
The underlying molecular mechanisms that promote autoimmune disease progression are complex and multi-layered
.
Scientists at the University of Würzburg (JMU) have succeeded in deciphering the underlying molecular mechanisms that promote autoimmune diseases
.
Their research suggests that excessive intake of glucose directly promotes the pathogenic function of certain cells of the immune system, and that, conversely, a reduced-calorie diet can have beneficial effects on immune diseases
.
Based on these findings, they also identified new targets for therapeutic intervention: blocking glucose-dependent metabolic processes in these immune cells to suppress excessive immune responses
.
The findings were recently published in the journal Cell Metabolism, titled: "The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming"
.
https://doi.
org/10.
1016/j.
cmet.
2022.
02.
015 Glucose transporter with 'sideline' explains Dr Martin Väth, who led the study: "Immune cells require large amounts of sugar in the form of glucose to complete their Task
.
With the help of special transporters on the cell membrane, they can take up glucose from the environment
.
"Väth and his team demonstrated that a special glucose transporter scientifically named GLUT3 performs additional metabolic functions in T cells in addition to producing energy from sugar
.
In their study, the scientists focused on placed on a lesser-known group of cells in the immune system: Type 17 T helper cells, also known as Th17 lymphocytes, which play an important role in regulating (auto)inflammatory processes
.
"These Th17 cells are on the cell surface .
Expresses a large amount of the GLUT3 protein,” explains Väth
.
Once absorbed, glucose is easily converted to citrate in the mitochondria and then metabolized to acetyl-CoA (acetyl-CoA) in the cytoplasm
.
Acetyl-CoA is involved in many metabolic processes, including lipid Biosynthesis of cytoplasm
.
Graphical summary of effects on pro-inflammatory genes Acetyl-CoA, however, has other functions in inflammatory Th17 cells
.
Väth and his team showed that this metabolic intermediate can also regulate the activity of various gene fragments Therefore
,
glucose intake has a direct effect on the activity of pro-inflammatory genes
.
The researchers say these new findings pave the way for the development of targeted treatments for autoimmune diseases
.
For example, by the dietary supplement hydroxycitrate (used for Obesity treatment) Blockade of GLUT3-dependent acetyl-CoA synthesis can alleviate the pathogenic function of Th17 cells and reduce inflammatory pathological processes
.
T cell "metabolic reprogramming" offers new possibilities for the treatment of autoimmune diseases without Impairs the function of protective immune cells
.
Reference: https://medicalxpress.
com/news/2022-03-sugar-inflammation.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·Activity Click the text to view the details.
March 24th 19:00-20:30 Online Multiple Myeloma Research Progress and Application of MRD March 30th 19:00-21:00 Online Proteomics Frontiers and Advances Innovative Technology Outlook Webinar March 31st 19:00-21:00 Online Sharing of Global Technology | Tumor Precision Diagnosis Innovation and Development Webinar (coming soon) April 14th 09:00-18:00 Beijing Third 2018 Single-Cell Sequencing Technology Application Forum (coming soon) April 20, 09:00-18:00 How to improve the efficiency of new macromolecular drug research and development from basic experiments (coming soon)
Please indicate the source when reprinting
.
In people with autoimmune diseases, the immune system attacks the body's own tissues, such as chronic inflammatory bowel disease (such as Crohn's disease and ulcerative colitis), type 1 diabetes, and chronic inflammation of the thyroid
.
The underlying molecular mechanisms that promote autoimmune disease progression are complex and multi-layered
.
Scientists at the University of Würzburg (JMU) have succeeded in deciphering the underlying molecular mechanisms that promote autoimmune diseases
.
Their research suggests that excessive intake of glucose directly promotes the pathogenic function of certain cells of the immune system, and that, conversely, a reduced-calorie diet can have beneficial effects on immune diseases
.
Based on these findings, they also identified new targets for therapeutic intervention: blocking glucose-dependent metabolic processes in these immune cells to suppress excessive immune responses
.
The findings were recently published in the journal Cell Metabolism, titled: "The glucose transporter GLUT3 controls T helper 17 cell responses through glycolytic-epigenetic reprogramming"
.
https://doi.
org/10.
1016/j.
cmet.
2022.
02.
015 Glucose transporter with 'sideline' explains Dr Martin Väth, who led the study: "Immune cells require large amounts of sugar in the form of glucose to complete their Task
.
With the help of special transporters on the cell membrane, they can take up glucose from the environment
.
"Väth and his team demonstrated that a special glucose transporter scientifically named GLUT3 performs additional metabolic functions in T cells in addition to producing energy from sugar
.
In their study, the scientists focused on placed on a lesser-known group of cells in the immune system: Type 17 T helper cells, also known as Th17 lymphocytes, which play an important role in regulating (auto)inflammatory processes
.
"These Th17 cells are on the cell surface .
Expresses a large amount of the GLUT3 protein,” explains Väth
.
Once absorbed, glucose is easily converted to citrate in the mitochondria and then metabolized to acetyl-CoA (acetyl-CoA) in the cytoplasm
.
Acetyl-CoA is involved in many metabolic processes, including lipid Biosynthesis of cytoplasm
.
Graphical summary of effects on pro-inflammatory genes Acetyl-CoA, however, has other functions in inflammatory Th17 cells
.
Väth and his team showed that this metabolic intermediate can also regulate the activity of various gene fragments Therefore
,
glucose intake has a direct effect on the activity of pro-inflammatory genes
.
The researchers say these new findings pave the way for the development of targeted treatments for autoimmune diseases
.
For example, by the dietary supplement hydroxycitrate (used for Obesity treatment) Blockade of GLUT3-dependent acetyl-CoA synthesis can alleviate the pathogenic function of Th17 cells and reduce inflammatory pathological processes
.
T cell "metabolic reprogramming" offers new possibilities for the treatment of autoimmune diseases without Impairs the function of protective immune cells
.
Reference: https://medicalxpress.
com/news/2022-03-sugar-inflammation.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·Activity Click the text to view the details.
March 24th 19:00-20:30 Online Multiple Myeloma Research Progress and Application of MRD March 30th 19:00-21:00 Online Proteomics Frontiers and Advances Innovative Technology Outlook Webinar March 31st 19:00-21:00 Online Sharing of Global Technology | Tumor Precision Diagnosis Innovation and Development Webinar (coming soon) April 14th 09:00-18:00 Beijing Third 2018 Single-Cell Sequencing Technology Application Forum (coming soon) April 20, 09:00-18:00 How to improve the efficiency of new macromolecular drug research and development from basic experiments (coming soon)
