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This article was originally written by Translational Medicine.
Please indicate the source.
Author: Liz Zee Introduction: Melbourne researchers have found that a type of immune cell that fights infection in newborns and infants can actually cannibalize the function of other immune cells.
Immune cells have emerged as potential new targets for the development of a range of infection therapies
.
Recently, an article was published in "Science" entitled "Marginal zone B cells acquire dendritic cell functions by trogocytosis"
.
After 15 years of research, the Peter Doherty Institute for Infection and Immunity and the Bio21 Institute have discovered that so-called marginal zone (MZ) B cells can actually "steal" the functions of dendritic cells, which feed us The immune system's sentinel to sound the alarm of infection
.
https:// If further research can reveal how this happens, it may be possible to use MZ B cells to enhance the immune response to specific infections
.
"This discovery is important because if we know the true function of MZ B cells, then we may be able to design vaccines or therapies that use them to enhance our immunity
.
" Professor at the University of Melbourne, the Doherty Institute and said Jose Villadangos, laboratory leader at the Bio21 Institute and co-principal investigator of the study
.
MZ B cells, which produce antibodies to attack multiple infections, and dendritic cells, which coordinate immune responses, both play very important roles in the immune system, but until now they were thought to work independently of each other
.
"Early in our lives, MZ B cells play a crucial role in preventing infection by producing antibodies that neutralize a wide range of bacteria in newborns and infants, " explains Professor Villadangos
.
"As we grow and develop, other cells take over this task and become the primary contributors to long-term immunity, but we believe that MZ B cells still retain a unique ability to potentially aid in the fight at any stage of the body's growth.
Certain pathogens .
" said Justine Mintern, associate professor at the University of Melbourne, laboratory leader at the Bio21 Institute, and co-author of the research paper, MZ B cells are thought to have a limited contribution to immune defence because they appear to be incapable of carrying out some key functions .
"In particular, we believe that MZ B cells cannot coordinate the actions of different immune cells, a function that only dendritic cells have, " Associate Professor Mintern said .
"Our study is changing this perception and opens up new possibilities for fully exploiting the functions of MZ B cells .
MZ B cells engulf dendritic cells and acquire MHC II molecules bound to complement C3 for antigen presentation.
to CD4+ T cells .
In this study, the researchers discovered a novel mechanism whereby MZ B cells are able to tightly interact with dendritic cells and acquire membrane proteins (primary undertakers of biofilm function) that enable dendritic cells to interact with dendritic cells T cells of the immune system communicate, thereby triggering an immune response .
These membrane proteins, known as MHC molecules, are highly specialized receptors exposed on the surface of dendritic cells .
The researchers found that MZ B cells interact with dendritic cells through the innate immune system . This is our innate immune system that fights a wide variety of infections, but unlike the adaptive immune system, the innate immune system can only fight off foreign infections in a non-specific way
.
They found that a protein in the innate immune system called complement C3 can bind to dendritic cells through MHC receptors, and MZ B cells can then use these proteins to connect with dendritic cells
.
"We are the first research team to discover this link between MZ B cells and dendritic cells," Associate Professor Mintern said
.
"Once complement C3 binds to the MHC receptor, MZ B cells use their own receptor to specifically bind to C3 and move closer to the dendritic cells," explains Dr.
Patrick Schriek, first author of the paper
.
"Then, the magic happened: MZ B cells tore the surface of the dendritic cell, the cytoplasmic membrane, and engulfed it
.
This is a cellular cannibalism called trogocytosis
"
The results show that after MZ B cells engulf dendritic cells, they can use MHC molecules captured from dendritic cells to communicate with T cells
.
In fact, MZ B cells can disguise themselves as dendritic cells
.
" "We didn't expect such an amazing discovery.
Peter Doherty was awarded the Nobel Prize in 1996 for describing the function of the MHC molecule for the first time
.
I've been studying MHC molecules for over 30 years and I never thought we'd stumble across it.
Discover new functions of these molecules, let alone discover them at the institute named after Professor Doherty, " said Professor Villadangos
.
"Our next challenge is figuring out how to take full advantage of the newly discovered properties of MZ B cells and unearth their yet-to-be-discovered functions," said Professor Villadangos
.
"Our lab is working with partners in academia and industry.
We are collaborating in various ways to test and improve new vaccine designs and immunotherapies
.
Our ultimate goal is to be able to use MZ B cells in a new way to fight infection
,
" Associate Professor Mintern said
.
"We may be able to develop more effective strategies to prevent or fight infection using vaccines, not vaccines on the traditional rule, but the use of 'cannibalistic' MZ B cells to improve the prevention or fight against infection.
Effect
.
"Reference: https://medicalxpress.
com/news/2022-02-cannibal-immune-cells-treatment-path.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·EventFebruary 21st 16:00-17:00 Online Olink New Generation Plasma Proteomics Analysis Helps Human Health and Disease Research Webinar February 22nd 13:00-13:45 Online RWD Drives Oncology Medicine Precision Webinar February 23, 19:30-21:15 Online Webinar on the Application of New Panel Design Tools and Bioinformatics Analysis Process in Cancer Research March 03, 15:30-20:00 Shanghai Innovation Technology Transformation Strategies and Industrial Development Thinking Private Sharing Session March 04 09:00-18:00 Shanghai First Yangtze River Delta Single Cell Omics Technology Application Forum April 14 09:00-18:00 Beijing 3rd Single Cell Sequencing Technology Application Forum (coming soon)
Please indicate the source.
Author: Liz Zee Introduction: Melbourne researchers have found that a type of immune cell that fights infection in newborns and infants can actually cannibalize the function of other immune cells.
Immune cells have emerged as potential new targets for the development of a range of infection therapies
.
Recently, an article was published in "Science" entitled "Marginal zone B cells acquire dendritic cell functions by trogocytosis"
.
After 15 years of research, the Peter Doherty Institute for Infection and Immunity and the Bio21 Institute have discovered that so-called marginal zone (MZ) B cells can actually "steal" the functions of dendritic cells, which feed us The immune system's sentinel to sound the alarm of infection
.
https:// If further research can reveal how this happens, it may be possible to use MZ B cells to enhance the immune response to specific infections
.
"This discovery is important because if we know the true function of MZ B cells, then we may be able to design vaccines or therapies that use them to enhance our immunity
.
" Professor at the University of Melbourne, the Doherty Institute and said Jose Villadangos, laboratory leader at the Bio21 Institute and co-principal investigator of the study
.
MZ B cells, which produce antibodies to attack multiple infections, and dendritic cells, which coordinate immune responses, both play very important roles in the immune system, but until now they were thought to work independently of each other
.
"Early in our lives, MZ B cells play a crucial role in preventing infection by producing antibodies that neutralize a wide range of bacteria in newborns and infants, " explains Professor Villadangos
.
"As we grow and develop, other cells take over this task and become the primary contributors to long-term immunity, but we believe that MZ B cells still retain a unique ability to potentially aid in the fight at any stage of the body's growth.
Certain pathogens .
" said Justine Mintern, associate professor at the University of Melbourne, laboratory leader at the Bio21 Institute, and co-author of the research paper, MZ B cells are thought to have a limited contribution to immune defence because they appear to be incapable of carrying out some key functions .
"In particular, we believe that MZ B cells cannot coordinate the actions of different immune cells, a function that only dendritic cells have, " Associate Professor Mintern said .
"Our study is changing this perception and opens up new possibilities for fully exploiting the functions of MZ B cells .
MZ B cells engulf dendritic cells and acquire MHC II molecules bound to complement C3 for antigen presentation.
to CD4+ T cells .
In this study, the researchers discovered a novel mechanism whereby MZ B cells are able to tightly interact with dendritic cells and acquire membrane proteins (primary undertakers of biofilm function) that enable dendritic cells to interact with dendritic cells T cells of the immune system communicate, thereby triggering an immune response .
These membrane proteins, known as MHC molecules, are highly specialized receptors exposed on the surface of dendritic cells .
The researchers found that MZ B cells interact with dendritic cells through the innate immune system . This is our innate immune system that fights a wide variety of infections, but unlike the adaptive immune system, the innate immune system can only fight off foreign infections in a non-specific way
.
They found that a protein in the innate immune system called complement C3 can bind to dendritic cells through MHC receptors, and MZ B cells can then use these proteins to connect with dendritic cells
.
"We are the first research team to discover this link between MZ B cells and dendritic cells," Associate Professor Mintern said
.
"Once complement C3 binds to the MHC receptor, MZ B cells use their own receptor to specifically bind to C3 and move closer to the dendritic cells," explains Dr.
Patrick Schriek, first author of the paper
.
"Then, the magic happened: MZ B cells tore the surface of the dendritic cell, the cytoplasmic membrane, and engulfed it
.
This is a cellular cannibalism called trogocytosis
"
The results show that after MZ B cells engulf dendritic cells, they can use MHC molecules captured from dendritic cells to communicate with T cells
.
In fact, MZ B cells can disguise themselves as dendritic cells
.
" "We didn't expect such an amazing discovery.
Peter Doherty was awarded the Nobel Prize in 1996 for describing the function of the MHC molecule for the first time
.
I've been studying MHC molecules for over 30 years and I never thought we'd stumble across it.
Discover new functions of these molecules, let alone discover them at the institute named after Professor Doherty, " said Professor Villadangos
.
"Our next challenge is figuring out how to take full advantage of the newly discovered properties of MZ B cells and unearth their yet-to-be-discovered functions," said Professor Villadangos
.
"Our lab is working with partners in academia and industry.
We are collaborating in various ways to test and improve new vaccine designs and immunotherapies
.
Our ultimate goal is to be able to use MZ B cells in a new way to fight infection
,
" Associate Professor Mintern said
.
"We may be able to develop more effective strategies to prevent or fight infection using vaccines, not vaccines on the traditional rule, but the use of 'cannibalistic' MZ B cells to improve the prevention or fight against infection.
Effect
.
"Reference: https://medicalxpress.
com/news/2022-02-cannibal-immune-cells-treatment-path.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·EventFebruary 21st 16:00-17:00 Online Olink New Generation Plasma Proteomics Analysis Helps Human Health and Disease Research Webinar February 22nd 13:00-13:45 Online RWD Drives Oncology Medicine Precision Webinar February 23, 19:30-21:15 Online Webinar on the Application of New Panel Design Tools and Bioinformatics Analysis Process in Cancer Research March 03, 15:30-20:00 Shanghai Innovation Technology Transformation Strategies and Industrial Development Thinking Private Sharing Session March 04 09:00-18:00 Shanghai First Yangtze River Delta Single Cell Omics Technology Application Forum April 14 09:00-18:00 Beijing 3rd Single Cell Sequencing Technology Application Forum (coming soon)
