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This article was originally written by Translational Medicine.
Please indicate the source Author: Jasmine Introduction: Autoimmune diseases are caused when the immune system malfunctions and attacks the body's own structures
.
Although there is currently no cure for the disease, therapeutic measures can be used to slow its progression
.
Researchers from the Center for Physiology and Pharmacology at the Medical University of Vienna have discovered an important signaling pathway in immune cells, a discovery that could lead to the development of a new approach to the treatment of autoimmune diseases
.
Autoimmune diseases occur when the immune system malfunctions and attacks the body's own tissues
.
Although there is currently no cure for the disease, therapeutic measures can be used to slow its progression
.
Researchers from the Center for Physiology and Pharmacology at the Medical University of Vienna have discovered an important signaling pathway in immune cells, a discovery that could lead to the development of a new approach to the treatment of autoimmune diseases
.
Their study was recently published in the journal Cell Reports titled: "JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction" https://doi.
org/10.
1016/j.
celrep.
2022.
110420 The immune system protects the body from various infections and distinguishes between foreign threats and the body's own tissues
.
T cells are an important part of the immune system and are commanded and deployed by other immune cells (dendritic cells)
.
Dendritic cells are not only responsible for activating T cells but also inactivating them, mainly to prevent them from attacking the body's own tissues
.
This mechanism, known as immune tolerance, is currently the key to the treatment of autoimmune diseases, by which certain drugs (JAK inhibitors) can be used to inhibit T cell activity against endogenous structures, thereby slowing autoimmunity disease progression
.
JAK inhibitors are used to treat various autoimmune diseases, such as rheumatoid arthritis
.
JAK inhibitors have been shown in several studies to act on all immune cells simultaneously
.
A research team led by Gernot Schabbauer and Omar Sharif of the Center for Physiology and Pharmacology at the Medical University of Vienna investigated the specific effects of JAK inhibitors on dendritic cells, in particular, T-cell immune tolerance (peripheral T-cell tolerance) in the self.
role in immune diseases
.
Graphic summary In collaboration with scientists from the Christian Doppler Laboratory at the Medical University of Vienna and St.
Anna Children's Cancer Research, they discovered a link between immune cells and autoimmune diseases.
A key part of T-cell tolerance signaling in dendritic cells
.
"This allows dendritic cells to enhance the immune tolerance of T cells and prevent them from attacking the body's own tissues," explains Andrea Vogel, lead author of the study and researcher at the Institute of Vascular Biology and Thrombosis at the Medical University of Vienna
.
The researchers' discovery is a step toward a new cell-based approach to treating autoimmune diseases
.
The aim is to specifically target signaling pathways in dendritic cells to "turn off" misdirected T cells and slow the progression of autoimmune disease
.
Andrea Vogel emphasizes that this will be further investigated next: "The next thing we wanted to investigate is whether this signaling pathway in dendritic cells also plays a role in cancer
.
" Reference: https:// medicalxpress.
com/news/2022-02-discovery-central-pathway-immune-cells.
html Note: This article is intended to introduce medical research progress and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·EventFebruary 21st 16:00-17:00 Online Olink New Generation Plasma Proteomics Analysis Helps Human Health and Disease Research Webinar February 22nd 13:00-13:45 Online RWD Drives Oncology Medicine Precision Webinar February 23, 19:30-21:15 Online Webinar on the Application of New Panel Design Tools and Bioinformatics Analysis Process in Cancer Research March 03, 15:30-20:00 Shanghai Innovation Technology Transformation Strategies and Industrial Development Thinking Private Sharing Session March 04 09:00-18:00 Shanghai First Yangtze River Delta Single Cell Omics Technology Application Forum April 14 09:00-18:00 Beijing 3rd Single Cell Sequencing Technology Application Forum (coming soon)
Please indicate the source Author: Jasmine Introduction: Autoimmune diseases are caused when the immune system malfunctions and attacks the body's own structures
.
Although there is currently no cure for the disease, therapeutic measures can be used to slow its progression
.
Researchers from the Center for Physiology and Pharmacology at the Medical University of Vienna have discovered an important signaling pathway in immune cells, a discovery that could lead to the development of a new approach to the treatment of autoimmune diseases
.
Autoimmune diseases occur when the immune system malfunctions and attacks the body's own tissues
.
Although there is currently no cure for the disease, therapeutic measures can be used to slow its progression
.
Researchers from the Center for Physiology and Pharmacology at the Medical University of Vienna have discovered an important signaling pathway in immune cells, a discovery that could lead to the development of a new approach to the treatment of autoimmune diseases
.
Their study was recently published in the journal Cell Reports titled: "JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction" https://doi.
org/10.
1016/j.
celrep.
2022.
110420 The immune system protects the body from various infections and distinguishes between foreign threats and the body's own tissues
.
T cells are an important part of the immune system and are commanded and deployed by other immune cells (dendritic cells)
.
Dendritic cells are not only responsible for activating T cells but also inactivating them, mainly to prevent them from attacking the body's own tissues
.
This mechanism, known as immune tolerance, is currently the key to the treatment of autoimmune diseases, by which certain drugs (JAK inhibitors) can be used to inhibit T cell activity against endogenous structures, thereby slowing autoimmunity disease progression
.
JAK inhibitors are used to treat various autoimmune diseases, such as rheumatoid arthritis
.
JAK inhibitors have been shown in several studies to act on all immune cells simultaneously
.
A research team led by Gernot Schabbauer and Omar Sharif of the Center for Physiology and Pharmacology at the Medical University of Vienna investigated the specific effects of JAK inhibitors on dendritic cells, in particular, T-cell immune tolerance (peripheral T-cell tolerance) in the self.
role in immune diseases
.
Graphic summary In collaboration with scientists from the Christian Doppler Laboratory at the Medical University of Vienna and St.
Anna Children's Cancer Research, they discovered a link between immune cells and autoimmune diseases.
A key part of T-cell tolerance signaling in dendritic cells
.
"This allows dendritic cells to enhance the immune tolerance of T cells and prevent them from attacking the body's own tissues," explains Andrea Vogel, lead author of the study and researcher at the Institute of Vascular Biology and Thrombosis at the Medical University of Vienna
.
The researchers' discovery is a step toward a new cell-based approach to treating autoimmune diseases
.
The aim is to specifically target signaling pathways in dendritic cells to "turn off" misdirected T cells and slow the progression of autoimmune disease
.
Andrea Vogel emphasizes that this will be further investigated next: "The next thing we wanted to investigate is whether this signaling pathway in dendritic cells also plays a role in cancer
.
" Reference: https:// medicalxpress.
com/news/2022-02-discovery-central-pathway-immune-cells.
html Note: This article is intended to introduce medical research progress and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·EventFebruary 21st 16:00-17:00 Online Olink New Generation Plasma Proteomics Analysis Helps Human Health and Disease Research Webinar February 22nd 13:00-13:45 Online RWD Drives Oncology Medicine Precision Webinar February 23, 19:30-21:15 Online Webinar on the Application of New Panel Design Tools and Bioinformatics Analysis Process in Cancer Research March 03, 15:30-20:00 Shanghai Innovation Technology Transformation Strategies and Industrial Development Thinking Private Sharing Session March 04 09:00-18:00 Shanghai First Yangtze River Delta Single Cell Omics Technology Application Forum April 14 09:00-18:00 Beijing 3rd Single Cell Sequencing Technology Application Forum (coming soon)
