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A&R: IL-13Rα1-mediated signaling regulates age-related/autoimmune B cell expansion and lupus pathogenesis
Time of Update: 2022-05-19
Age-related / autoimmune B cells (ABC) are an emerging subset of B cells (in addition to the classic B cell markers, they also express myeloid markers such as the transcription factor T-bet and CD11c , so these cells are also called CD11c+ T -bet+ B cells), which are abnormally expanded in SLE .
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A 12-year follow-up study of 410,000 people: Genetic factors + unhealthy lifestyle can increase the risk of gout by up to 200%!
Time of Update: 2022-05-19
PKaplan-Meier survival curves showed that the risk of developing gout was highest for people with high genetic susceptibility and an unfavorable life> .
Kaplan-Meier survival curves showed that the risk of developing gout was highest for people with high genetic susceptibility and an unfavorable life> .
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Master these points, no need to worry about early diagnosis of rheumatoid disease
Time of Update: 2022-05-19
A prospective multicenter cohort study in China for patients with disease duration less than 1 year and at least one persistent joint swelling and pain has introduced a new classification criteria for early RA, as shown in Table 2.
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J Allergy Clin Immunol: Study Reveals Molecular Mechanism of Spesolimab in the Treatment of Pustular Psoriasis
Time of Update: 2022-05-19
In a study published today in J Allergy Clin Immunol, researchers sought to compare the molecular profiles of lesional and non-lesional skin from patients with GPP or palmoplantar pustulosis (PPP) with that of healthy volunteers and to investigate GPP.
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Inhibition of IL-12/IL-23 p40 subunits in skin and blood of patients with psoriasis by tofacitinib is dependent on studies of active interferon-gamma signaling in dendritic cells
Time of Update: 2022-05-19
These findings demonstrate for the first time that tofacitinib inhibits the IL-23/IL-12 shared subunit IL12B in dendritic cells by activating IFN-γ signaling, and that Pso patients with higher baseline levels of IFN-γ were treated with tofacitinib showed an improved clinical response .
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A&R: The role of maladaptive autophagy in the pathogenesis of autoimmune epitheliitis in Sjögren's syndrome
Time of Update: 2022-05-19
Methods: Primary SGEC isolated from the minor salivary glands of patients with primary SS or Sjögren's syndrome were assessed by flow cytometry, immunoblotting and immunofluorescence to assess autophagy (autophagic flux, light chain 3 IIB [LC3 -IIB] , p62 , LC3-IIB+/ lysosomal - associated membrane protein 1 [LAMP-1] staining), apoptosis (annexin V/ propidium iodide [PI] , caspase 3 ) and activation (intercellular adhesion molecules, vascular cell adhesion molecules) .
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Adherence and Persistence of Biopharmaceutical Treatment of Psoriasis
Time of Update: 2022-05-17
Adherence and persistence to biological therapy in patients with psoriasis is suboptimal; however, initial treatment options may be critical to ensure better medication adherence/durability .
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Exp Gerontol: Osteoarthritis may increase risk of atherosclerosis
Time of Update: 2022-05-16
e. , hip and knee, hand and general OA), and divided the results by subclinical AT, overt cardiovascular (CV) disease, and CV death were stratified .
, Association between osteoarthritis and atherosclerosis: A systematic review and meta-analysis.
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Semin Arthritis Rheum: Serum amyloid A levels may be used to predict the risk of rheumatoid arthritis
Time of Update: 2022-05-15
The association of serum amyloid A (SAA) consistent with rheumatoid arthritis (RA) is not fully established .
In addition, a related meta-analysis showed that SAA levels were associated with disease activity score 28 (DAS28) [r = 0.
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A&R: Birth Outcomes in Women Taking Hydroxychloroquine During Pregnancy: A Prospective Cohort Study
Time of Update: 2022-05-15
Conclusions: In this study, there was no evidence of an increased risk of structural birth defects or other adverse outcomes in women treated with HCQ during pregnancy, with the exception of head circumference at birth .
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Why is C3 and C4 complement so important in the diagnosis and treatment of systemic lupus erythematosus?
Time of Update: 2022-05-15
Anti-dsDNA antibodies and low complement levels are associated with infection and disease relapse in SLE patients
Anti-dsDNA antibodies and low complement levels are associated with infection and disease relapse in SLE patientsOne study retrospectively analyzed data from 173 hospitalizations in 142 patients, with an infection rate of 50.
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Med J Aust: Opioid therapy may be suboptimal for pain relief in patients with osteoarthritis
Time of Update: 2022-05-15
Systematic reviews and meta-analyses of randomized, placebo-controlled trials of opioid therapy for osteoarthritis pain were included .
RESULTS: Results from 19 trials (including 8965 participants; dose range, 10-126 MME/day) showed a small benefit of opioids for mid-term pain relief (mean difference [MD], -4.
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Indomethacin, meloxicam, celecoxib... What should I pay attention to when choosing non-steroidal anti-inflammatory drugs for the treatment of rigidity?
Time of Update: 2022-05-15
But it should be noted that new bone formation quality of lifeDue to the limited effect of non-steroidal anti-inflammatory drugs on the control of deep inflammation in the joint cavity, it is "powerless" for local soft tissue adhesion, so it is difficult to prevent the formation of osteophytes.
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J Clin Rheumatol: No significant difference in the risk of serious infections in rheumatoid arthritis with different JAK inhibitors
Time of Update: 2022-05-15
A meta-analysis published today in J Clin Rheumatol compared the relative safety of different JAK inhibitors in terms of the risk of serious infections in patients with rheumatoid arthritis .
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JEADV: Mapping biomarker research in atopic dermatitis and psoriasis
Time of Update: 2022-05-14
In particular, there is a need for scientific standards, digital ethics and responsible clinical application of biomarkers for atopic dermatitis/psoriasis, patient engagement, and use of biomarkers for children with atopic dermatitis/psoriasis or More work on the ethical impact of young people .
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J Clin Rheumatol: Carotid and femoral artery Doppler ultrasound can assess cardiovascular risk in women with rheumatoid arthritis
Time of Update: 2022-05-14
Recently, a study published in J Clin Rheumatol aimed to evaluate the Framingham score as low-risk patients with rheumatoid arthritis (RA) before and after the European League Against Rheumatism (EULAR) recommended multiplication of 1.
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A&R: 2021 American College of Rheumatology Guidelines for the Treatment of Juvenile Idiopathic Arthritis: Management of Oligoarthritis, TMJ Arthritis, and Systemic Juvenile Idiopathic Arthritis
Time of Update: 2022-05-14
Although the quality of evidence is generally low and many recommendations are conditional, including caregivers and patients in the decision-making process enhances the relevance and applicability of guidelines .
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J Clin Rheumatol: Is there an increased risk of infection in patients with rheumatoid arthritis using JAK inhibitors?
Time of Update: 2022-05-14
A meta-analysis published today in J Clin Rheumatol compared the relative safety of different JAK inhibitors in terms of the risk of serious infections in patients with rheumatoid arthritis .
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Thyroid: The relationship between primary thyroid lymphoma and thyroid autoimmune disease
Time of Update: 2022-05-14
The purpose of this study was to investigate the clinical characteristics, pathological outcomes and long-term outcomes of patients with PTL, according to the presence or absence of GD, HT or the absence of autoimmune thyroid diseases (AITDs).
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npj Parkinsons Dis: Rheumatoid Arthritis, Reduced Risk of Parkinson's Disease
Time of Update: 2022-05-14
Rheumatoid arthritis decreases risk for Parkinson's disease: a Mendelian randomization study.
Rheumatoid arthritis decreases risk for Parkinson's disease: a Mendelian randomization study.
Rheumatoid arthritis decreases risk for Parkinson's disease: a Mendelian randomization study.
