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Inhibition of IL-12/IL-23 p40 subunits in skin and blood of patients with psoriasis by tofacitinib is dependent on studies of active interferon-gamma signaling in dendritic cells

 Last Update: 2022-05-19
 Source: Internet
 Author: User

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Dendritic cells (DCs) are professional antigen-presenting cells that form the bridge between innate and acquired immunity

Interleukin (IL)-12 and IL-23 are pro-inflammatory cytokines produced by dendritic cells (DCs) and have been implicated in the pathogenesis of psoriasis (Pso) and psoriatic arthritis (PsA)

Taken together, our findings implicate a novel role for IFN-γ in the induction of tofacitinib inhibition of dendritic cell IL12B

Source: Vincken NLA, Welsing PMJ, Silva-Cardoso SCSuppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-γ signaling in dendritic cells: Implications for the treatment of psoriasis and interferon-driven diseases.

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