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Purpose: Salivary gland epithelial cells (SGECs) are key cellular drivers in the pathogenesis of primary Sjögren's syndrome (SS) ; however, the mechanisms that maintain SGEC activation in primary SS remain unclear .
Purpose: Salivary gland epithelial cells (SGECs) are key cellular drivers in the pathogenesis of primary Sjögren's syndrome (SS) ; however, the mechanisms that maintain SGEC activation in primary SS remain unclear .
Methods: Primary SGEC isolated from the minor salivary glands of patients with primary SS or Sjögren's syndrome wereassessed by flow cytometry, immunoblotting and immunofluorescence to assess autophagy (autophagic flux, light chain 3 IIB [LC3 -IIB] , p62 , LC3-IIB+/ lysosomal - associated membrane protein 1 [LAMP-1] staining), apoptosis (annexin V/ propidium iodide [PI] , caspase 3 ) and activation (intercellular adhesion molecules, vascular cell adhesion molecules) .
Results: SGEC from primary SS patients ( n=24) exhibited increased autophagy (autophagic flux [P=0.
Conclusions: In primary SS salivary gland epithelial cells, inflammation induces autophagy and pro-survival mechanisms that promote salivary gland epithelial cell activation and reflect histological severity
Colafrancesco, S.
, Barbati, C.
, Priori, R.
, et al.
(2022), Maladaptive Autophagy in the Pathogenesis of Autoimmune Epithelitis in Sjögren's Syndrome.
Arthritis Rheumatol, 74: 654-664.
https://doi.
org /10.
1002/art.
42018
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