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Master of Immunization: A Complete Summary of Academician Dong Chen's Research Results
Time of Update: 2022-06-03
Then Dong Chen's team discovered the important transcription factors RORA and ROEC that regulate Th17, and the corresponding results were published in the journal immunity in 2008 with an article entitled: T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma , this research is also the second most cited research by Mr.
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2 STTT finally solved the mystery!
Time of Update: 2022-06-03
Sensing of viral nucleic acids by the PRR triggers a signaling cascade that induces the transcription of type I interferons (IFNs), pro-inflammatory cytokines, and other downstream antiviral effector genes .
Downstream cytokines and effectors inhibit viral replication or induce apoptosis in infected cells, resulting in an innate antiviral response .
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Does lupus always recur?
Time of Update: 2022-06-03
Professor Ye Shuang's team found through clinical trials (NCT02741960): SLE patients with low disease activity but high risk of recurrence, combined with metformin therapy, has the potential to reduce disease recurrence, especially major recurrence.
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Can anti-MDA5 antibody-related myopathy be diagnosed according to EULAR/ACR criteria?
Time of Update: 2022-06-02
*Only medical professionals can read and refer to clinical information, reachable in 1s ▎Clinical question: How does the 2017 EULAR/ACR classification standard perform in the diagnosis of anti-MDA5 antibody-related idiopathic inflammatory myopathy (IIM)?
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Cancer Cell recognizes human lung cancer antigens
Time of Update: 2022-06-02
In conclusion, the authors identified a set of CD39 and CXCL13-based molecular signatures of T cells that can rapidly recognize tumor antigens by analyzing the transcriptome and TCR of tumor-infiltrating lymphocytes from four patients with non-small cell lung cancer .
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Cardiac arrest in patients with myalgia and dyspnea is actually not uncommon!
Time of Update: 2022-06-02
The patient reported having a viral upper respiratory tract infection 3 months ago, and symptoms of fatigue, diffuse myalgia, and dyspnea gradually developed and worsened within 2 months .
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How should I take medicine?
Time of Update: 2022-05-31
[2] Yu Zaoqin, Zhang Chengliang, Wang Youqun, Liu Dong.
The specific application of Shichen pharmacology in the time of taking medication and its effect on pharmacodynamics [J].
Shichen Pharmacology and Clinical Rational Drug Use [J].
Relationship between Shichen Pharmacology and Clinical Rational Drug Use[J].
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Immune-Related Adverse Events: Regulatory T Cells
Time of Update: 2022-05-30
Abstract: While regulatory T cells (Treg) are a direct target of immune checkpoint inhibitor (ICI) immunotherapy, inflammatory Treg reprogramming is also a feature of immune-related adverse events (irAEs) in autoimmune diseases .
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Science｜Single-cell omics analysis of systemic lupus erythematosus
Time of Update: 2022-05-29
Using mux-seq phylotype analysis, the authors analyzed changes in cell composition and specific transcriptional signatures of different cell types in patients with systemic lupus erythematosus, and annotated genetically associated loci for clinical research and Drug development provides a new database of resources .
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Cell Li Xiaofei et al reveal that chronic comorbidities are linked through innate immune memory
Time of Update: 2022-05-29
The long article of myelopoiesis links inflammatory comorbidities reveals for the first time that peripheral inflammatory signaling-induced innate immune memory at the level of bone marrow hematopoietic stem/progenitor cells promotes chronic inflammatory disease progression and links the molecular mechanisms of chronic comorbidities .
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JCI Insight Zhu Xuan/Huang Jiandong/Chen Fuhe team confirmed that BCG can induce training immunity against new coronavirus infection
Time of Update: 2022-05-29
Although several vaccines have been certified by the World Health Organization and are being administered globally, multiple SARS-CoV-2 variants have been reported to escape neutralizing antibodies, leading to vaccine breakthrough infections .
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The symptoms of nearly half of the express patients improved by at least 40%, and AbbVie's JAK inhibitor was approved by the FDA
Time of Update: 2022-05-28
S. FDA approved the expanded indication of its JAK inhibitor Rinvoq (upadacitinib, upadacitinib) for the treatment of active ankylosing spondylitis (ankylosing spondylitis, AS) adult patients .
Reference: [1] RINVOQ® (upadacitinib) Approved by US FDA as an Oral Treatment for Adults with Active Ankylosing Spondylitis.
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What are the main clinical features of acute gouty arthritis?
Time of Update: 2022-05-28
The main clinical features of acute gouty arthritis do not include A.
Treatment with colchicine provides rapid relief of arthritis symptoms C.
Severe pain, often self-limited at first attack D.
Link to previous article: Which autoantibodies are more specific in rheumatoid arthritis?
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Express for autoimmune diseases, Xinrui received $100 million to help develop a new generation of complement therapy
Time of Update: 2022-05-27
▎WuXi AppTec Content Team Editor Today, Dianthus Therapeutics announced the completion of a $100 million Series A financing, which will be used to expand the company’s team, advance its flagship project DNTH103 into the clinic, and accelerate the treatment of severe and rare autoimmune diseases.
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Ping Jihui's team from Nanjing Agricultural University reviewed the virus-host interaction network as a new antiviral drug target for influenza A and COVID-19
Time of Update: 2022-05-27
- A review paper on Host Interaction Networks as Novel Antiviral Drug Targets for IAV and SARS-CoV-2) .
It is particularly noteworthy that the virus-host interaction network contains three main antiviral drug targets: viral targets, host targets and the antagonism of viruses on the host's innate immunity.
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Three minutes to teach you to "understand the three items of rheumatism" test sheet
Time of Update: 2022-05-27
It is necessary to detect anti-streptococcus bacterial antigens at the same time and make a diagnosis based on clinical manifestations; ● Because people often come into contact with group A streptococcus, normal people also have low levels of The titer of antibodies, usually <133IU/ml, is considered diagnostic value when the titer is >200IU/ml .
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ARD: Mechanical overload promotes chondrocyte senescence and osteoarthritis development through downregulation of FBXW7
Time of Update: 2022-05-25
Mechanistically, mechanical overload reduces Fbxw7 mRNA transcription and FBXW7 -mediated degradation of MKK7 , thereby stimulating JNK signaling .
Mechanistically, mechanical overload reduced Fbxw7 mRNA Fbxw7 transcription and FBXW7 -mediated MKK7 degradation, thereby stimulating JNK signaling .
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ARD: Use of TNF inhibitors in children with juvenile idiopathic arthritis increases psoriasis incidence
Time of Update: 2022-05-22
Researchers aimed to investigate the association between tumor necrosis factor inhibitor (TNFi) treatment and new-onset psoriasis in children with juvenile idiopathic arthritis (JIA) using data from the Childhood Arthritis and Rheumatology Research Consortium (CARRA) registry .
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A&R: Tumor necrosis factor inhibitor therapy is associated with a time-shifted delay in radiographic sacroiliitis progression in patients with axial spondyloarthritis
Time of Update: 2022-05-22
In a long-term initial cohort study, we investigated the longitudinal association between radiographic sacroiliitis progression and tumor necrosis factor inhibitor (TNFi) treatment in patients with early axSpA .
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A&R: Host genetics, not commensal microbiota, determines initial development of systemic autoimmune disease in BXD2 mice
Time of Update: 2022-05-19
RESULTS: In 6 -month-old mice, GF status did not affect splenomegaly, GC B cells, age-related B cells, or serum autoantibody levels, with the exception of IgG anti-histone .
