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Pegolase + methotrexate has become the "nemesis" of refractory gout?
Time of Update: 2022-06-11
Results showed that patients receiving methotrexate in combination with pegloticase achieved a higher proportion of sustained SUA levels <6 mg/dl, a lower incidence of infusion reactions, and no new safety concerns during the 6-month treatment period [ 7] .
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A 26-year-old woman with massive proteinuria was diagnosed with this rheumatism due to dry skin?
Time of Update: 2022-06-11
The diagnosis revealed that the doctor suspected that the woman had primary Sjögren's syndrome (pSS), so the examination in this area was especially perfected, and the meaningful results are as follows .
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"Nature" heavy: Li Ming's team discovered a new type of anti-cancer T cells!
Time of Update: 2022-06-11
▎WuXi AppTec Content Team Editor On April 20, Zhou Jun, Zhang Zhen and collaborators from Professor Li Ming's laboratory at Memorial Sloan-Kettering Cancer Center published a paper in the journal Nature, revealing that an immune A new mechanism of anti-cancer, and the discovery of a T cell with great anti-cancer potential is expected to promote the development of immunotherapy in a new direction .
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Odyssey In-Cell Western for quantification of Chlamydia trachomatis and screening of anti-chlamydia drugs
Time of Update: 2022-06-10
As a quantitative immunofluorescence (IF) assay method developed by LI-COR in the United States, ICW has been widely used in autophagy, apoptosis, cancer, drug research, signal transduction, ion channels, Gene expression, virological detection, cell proliferation experiments, etc.
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Semin Cancer Biol Cheng Chunming/Yi Ping/Wang Yi published a review on the metabolic regulation of tumor immune checkpoints and new strategies for tumor immunotherapy
Time of Update: 2022-06-10
iNature immune checkpoint inhibitors (ICIs) activate the immune system to attack tumor cells by inhibiting immune checkpoints on tumor cells or immune cells . The clinical application of immune ch
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Take this medicine, be careful that the patient's gout will not get better!
Time of Update: 2022-06-10
The second indication is not suitable for prescription: a 42-year-old male patient, diagnosed with gout (acute attack), checked the serum uric acid 525µmol/L, and prescribed allopurinol tablets 100mg twice a day, orally .
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AS Excellent Case Sharing - Impaired Functions and Limited Activities, How to "Turn Things Around"?
Time of Update: 2022-06-09
*For medical professionals to read and refer to the sharing of outstanding cases of C pioneers - from clinical real cases, to discuss the first-line selection of AS biologics . As the backbone of
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What are the main clinical manifestations of systemic lupus erythematosus?
Time of Update: 2022-06-08
Anemia in the previous stage Answer: C Analysis: Rheumatoid factor positive is only seen in 70% of the patients In patients with rheumatoid arthritis, it can also be seen in other autoimmune diseases, so the diagnosis should be made in combination with clinical manifestations (do not choose A) .
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3 high school students, with scientists, published a "Science": They uncovered the key mechanism of the immune response
Time of Update: 2022-06-08
▲ The process of macrophages entering embryonic tissues (Image source: Maria Akhmanova) For researchers, there is still a problem that has not been explained: what really causes macrophages to enter is the morphological change of cells or the weakening of cell connections ?
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Nature: Why is the mRNA vaccine developed for the original strain effective against Omicron when used as a booster?
Time of Update: 2022-06-08
The study showed that a third dose of the mRNA vaccine developed for the original new coronavirus (SARS-CoV-2) strain enhanced the immune system's ability to produce broadly neutralizing antibodies, including the ability to produce broadly neutralizing antibodies, compared with just two doses.
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Science Zhao Xiang reveals the precise regulation of the activity of T cell receptors using the reverse lock key for tumor immunotherapy
Time of Update: 2022-06-08
The T cell receptor (TCR) recognizes its ligand peptide-major histocompatibility complex (pMHC), and this protein interaction determines the antigen specificity and activation of T cells strength .
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Cell Host & Microbe sulfonamides in the treatment of Firmicutes bacterial infections can cause STING-mediated inflammatory responses
Time of Update: 2022-06-08
In conclusion, this study demonstrates that blockade of thymidine metabolism in Firmicutes by sulfonamides leads to c-di-AMP-mediated activation of the STING pathway, revealing the effect of antibiotic treatment on the host's innate immune response .
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JCI Insight: Zhu Xuan/Huang Jiandong/Chen Fuhe team confirmed that BCG can induce training immunity against new crown infection
Time of Update: 2022-06-08
On April 21, the latest research results completed by the Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, and the Faculty of Medicine of the University of Hong Kong and other units: Bacillus Calmette–Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18 -hACE2 mice are published in the journal JCI Insight .
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A shorthand!
Time of Update: 2022-06-07
With item 5, plus three or four items can be diagnosed as dermatomyositis; with item 5, plus two possible dermatomyositis, plus one suspected dermatomyositis .
References: [1]Bohan, A.
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3 high school students, together with scientists, published Science: They uncovered the key mechanism of the immune response
Time of Update: 2022-06-07
The study found that Drosophila macrophage invasion of embryonic tissue requires division of epithelial ectoderm cells at the entry site .
Dividing ectodermal cells break down ECM attachments formed by integrin-mediated mesodermal cell focal adhesions, allowing macrophages to move their nuclei forward and invade between two immediately adjacent tissues .
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Rheumatoid arthritis, how to take medicine outside the instructions?
Time of Update: 2022-06-07
The consensus writing group formulated 12 recommendations after repeated discussions and revisions through literature review, expert consultation, the US IBM MICROMEDEX database, domestic and foreign drug instructions, and domestic and foreign RA-related treatment guidelines .
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Sinusitis patients with cough, myalgia, and finally cerebral infarction are admitted to the hospital, but it is not so simple!
Time of Update: 2022-06-05
Table 1 Laboratory values of the patient out-of-hospital and during admission At this time, the results of a renal biopsy previously performed out-of-hospital were also available, showing pauci-immune complex glomerulonephritis with massive eosinophilic infiltrates and small interstitial fibrosis or renal tubular atrophy .
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Low back pain may not be due to lumbar muscle strain, but because of this disabling rheumatism!
Time of Update: 2022-06-05
Ankylosing spondylitis needs timely drug treatment to control symptoms and delay the progression of the disease: start anti-inflammatory treatment as soon as possible, which can quickly relieve low back pain, improve morning stiffness, joint swelling and pain and other symptoms; inhibit the progress of bone destruction and protect joint function , in order to fundamentally ensure the long-term quality of life of patients!
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SCM2022 Conference Intelligence Express Lupus Nephritis New Dawn - VOCLOSPORIN?
Time of Update: 2022-06-05
For patients on Voclosporin, regardless of whether complete renal remission was achieved at week 52, anti-dsDNA levels were decreased and C3 complement levels were increased .
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CTD Journal Inhaled ibuprofen salts have potential to reverse pulmonary vascular paralysis in patients with COVID-19 pneumonia
Time of Update: 2022-06-05
Recent studies have shown that an inhaled, non-hormonal anti-inflammatory drug, sodium ibuprofen (NaIHS) dissolved in hypertonic sodium salts, can relieve hypoxia symptoms in patients with moderate to severe COVID-19 pneumonia .
When a patient with COVID-19 presents with symptoms of vasoplegia, we call it COVID-19 L type .
