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For rheumatism patients preparing for pregnancy, which drugs should be stopped and which should not be stopped?
Time of Update: 2022-06-16
In addition, pregnancy in patients with RMDs can lead to serious adverse maternal and fetal outcomes, and the risk of pregnancy complications depends on diagnosis, disease activity and degree of impairment, drug use, presence of anti-SSA/Ro or anti-SSB/La, and antiphospholipid antibodies (aPL).
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The "retroperitoneal mass" was thought to be cancer, and the differential diagnosis was finally made clear!
Time of Update: 2022-06-16
Let's think about it again, the patient's symptoms (abdominal pain), retroperitoneal space mass, MRI shows low signal on T1, a large number of lymphocytes, plasma cells are seen under the microscope.
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When gout flares up after vaccination, colchicine reduces risk by 47%!
Time of Update: 2022-06-16
*For medical professionals to read and refer to clinical information, 1s touches ▎Clinical question: What is the risk of gout attack 3 months after vaccination with COVID-19?
Vaccination was associated with an increased risk of gout flares within 3 months compared with participants who were not vaccinated against COVID-19 (adjusted OR 6.
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X-ray examination showed spinal bamboo-like changes, what is the disease?
Time of Update: 2022-06-16
Systemic lupus erythematosus Upper stage Answer: E Analysis: Rheumatoid Arthritis most often affects the whole body, symmetrical, multiple small joints, such as proximal interphalangeal joints, metacarpophalangeal joints, wrist joints, followed by elbow joints, etc.
_ Link to previous article: Which joint is most commonly affected by rheumatoid arthritis?
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Rejuvenate your immune system!
Time of Update: 2022-06-15
(Image source: Reference [1]) Corresponding author Professor Michael Demetriou of the UCI School of Medicine said: "Our study shows that reversing the accumulation of branched glycans can restore T cell function to a youthful state in both humans and mice .
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Lupus nephritis (type IV), what is the preferred immunosuppressant?
Time of Update: 2022-06-15
② Osteoarthritis, rheumatoid arthritis, reactive arthritis, and systemic lupus erythematosus will not appear bamboo-like degeneration of the spine (B, C, D, E are not selected) .
Link to the previous article: X-ray examination shows bamboo-like changes in the spine, what is the disease?
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Is high uric acid just to prevent gout?
Time of Update: 2022-06-15
. The guidelines point out that controlling the blood uric acid level within 240-420 μmol/L can significantly reduce the frequency of gout attacks, prevent tophi formation, prevent bone destruction, reduce the risk of death and improve the quality of life of patients .
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Marginal zone B cells 'eaten' dendritic cells to 'hijack' their antigen-presenting function
Time of Update: 2022-06-15
The researchers discovered that the inactive form of C3, C3dg It can bind to pMHC II on cDC, while marginal zone B cells recognize C3 through complement receptor 2 (CR2), phagocytose the MHC II-C3dg complex through trogocytosis and present it to T cells .
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What is connective tissue disease?
Time of Update: 2022-06-15
That is, undifferentiated connective tissue disease has the clinical manifestations and immunological characteristics of some connective tissue diseases, but does not meet the classification criteria of any specific disease .
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Make new progress!
Time of Update: 2022-06-15
The study The hnRNP UL1 was identified as a negative regulator of NF-κB-mediated inflammation by functional screening of hnRNPs members in LPS-stimulated macrophage inflammatory responses .
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@Tonic patient, the first domestic oral JAK inhibitor approved for indications!
Time of Update: 2022-06-14
*For medical professionals to read and reference the first oral small molecule targeted drug in the field of rheumatism and immunity, bringing new treatment options for AS patients Pfizer announced on April 15 that China's National Medical Products Administration (NMPA) has approved citric acid Tofacitinib (trade name: Shangjie) is indicated for adult patients with active ankylosing spondylitis (AS) for whom one or more TNF blockers are insufficiently effective or intolerable .
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[Nature Sub-Journal] Opening the "black box" of immune checkpoint LAG3 - developing blocking therapies to treat cancer and autoimmune diseases
Time of Update: 2022-06-14
Recent studies have pinpointed how LAG3 regulates T cell activity, providing important insights into the development of other LAG3-blocking therapies to treat cancer and autoimmune diseases .
. Beyond cancer, Vignali said the research could lead to new treatments for autoimmune and inflammatory diseases .
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The team of Xu Huaqiang/Yin Wanchao of the Chinese Academy of Sciences and Jimin Trustworthy analyzed the mechanism of infection enhancement and immune escape of Omicron BA.1 and BA.2, and explored the potential evolutionary path of Omicron
Time of Update: 2022-06-14
Since November 2021 in iNature, the newly emerged Omicron variant, with enhanced infectivity, quickly replaced a variety of "worrisome variant (VOC)" dominated by Delta and became the main popular variant; at the same time, it carries a large number of mutations and has The strong immune escape ability has brought huge challenges to the global epidemic prevention and control .
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Acute gout is accompanied by fever and high blood pressure. The cause is actually this disease... 420 World Gout Day
Time of Update: 2022-06-14
5°C, without medication, considering acute gouty arthritis to be admitted to our department, poor spirit, normal appetite, no cough and expectoration, no chest tightness, no abdominal pain, no diarrhea, normal urine and stool , there was no significant change in body weight .
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Hormone intramuscular injection VS intra-articular injection, what should be the choice for patients with knee osteoarthritis?
Time of Update: 2022-06-14
This article explores the clinical practical question of whether intramuscular (IM) glucocorticoids are noninferior to intra-articular (IA) glucocorticoids in reducing pain in patients with knee osteoarthritis (KOA) .
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Immune-Related Adverse Reactions: An Overview
Time of Update: 2022-06-14
1. Anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) antibody: ipilimumab incidence of immune-related adverse events (irAEs) Ipilimumab is the first ICI to enter clinical trials, and its toxicity profile is the clearest .
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STTT makes new progress!
Time of Update: 2022-06-14
On April 18, 2022, Chen Yun from Nanjing Medical University, Wang Xuehao and Kuang Dongming from Sun Yat-Sen University jointly published an online article entitled "c-Myc-driven glycolysis polarizes functional regulatory B cells that trigger pathogenic inflammatory inflammatory disease" in Signal Transduction and Targeted Therapy (IF=18).
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Baby eat probiotics to prevent allergic diseases?
Time of Update: 2022-06-12
The study found that administering a probiotic supplement [Lactobacillus rhamnosus GG (LGG)] to high-risk infants during the first 6 months of life was not effective in reducing the incidence of eczema, asthma or rhinitis in later childhood .
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How to manage the hidden period of gouty arthritis?
Time of Update: 2022-06-12
Why do you have to treat it as usual, so it’s not a chronic disease?” “It seems that I am now in a hidden period of gouty arthritis.
The hidden period of gouty arthritis refers to only fluctuating or persistent hyperuricemia without acute attacks, that is, joint redness, swelling, heat and pain .
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Which description is correct about rheumatoid arthritis and rheumatoid factor?
Time of Update: 2022-06-11
The most commonly measured rheumatoid factor is IgG type Upper stage Answer: A Analysis: The preferred immunosuppressant for the treatment of lupus nephritis is cyclophosphamide (CTX), so this question selects A .
Link to previous article: Lupus nephritis (type IV), what is the preferred immunosuppressant?
