-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
▎WuXi AppTec Content Team Editor With the growth of age, the body's T cell immunity is impaired and gradually weakened.
An intuitive consequence is that the severity of the disease and the mortality rate of the elderly are significantly increased after being infected by the disease
.
In a study published in Nature Aging, a research team from the University of California, Irvine (UCI) has found a potential target that promises to rejuvenate the immune system of the elderly
.
"We may have found the 'fountain of youth' for the immune system," commented first author Haik Mkhikian, assistant professor in UCI's Department of Pathology
.
As commanders of the immune system, T cells coordinate the immune response in the body to fight infection
.
In T cells, a key component that changes with age is branched-chain glycans
.
In T cells, branched glycans increase with age
.
The study found greater increases in branched glycan content in female mice, influenced by the age-related sugar metabolites N-acetylglucosamine and interleukin 7
.
▲ Interleukin-7 signaling increases, increasing the branching of N-acetylglucosamine
.
(Image source: Reference [1]) Corresponding author Professor Michael Demetriou of the UCI School of Medicine said: "Our study shows that reversing the accumulation of branched glycans can restore T cell function to a youthful state in both humans and mice
.
In female aged mice, this change reduced the severity of Salmonella infection
.
" "Through this study, we gain new insights into why older adults are more vulnerable to infection, which will help develop potential new therapy
.
Professor Demetriou added
.
▲Professor Michael Demetriou led the team to reveal how to rejuvenate the immune system.
These include changes in branched-chain glycans, or age-related increases in serum N-acetylglucosamine or interleukin 7.
In
this study, the authors analyzed T cells in mice of different ages and sexes, and the results demonstrated gender-related differences
.
This finding also serves as a reminder that in order to effectively reverse immune dysfunction, we also need to develop new gender-related strategies
.
Reference: [1] Mkhikian, H.
, Hayama, KL, Khachikyan , K.
et al.
Age-associated impairment of T cell immunity is linked to sex-dimorphic elevation of N-glycan branching.
Nat Aging 2, 231–242 (2022).
https://doi.
org/10.
1038/s43587- 022-00187-y[2] New study from UCI reveals how to rejuvenate the immune system of elderly people and reduce their risk of infectious disease.
Retrieved Apr.
11, 2022 from https:// /949475
