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The increase of this factor will actually lead to an increase in the mortality rate of rheumatoid patients?
Time of Update: 2022-06-20
*For medical professionals to read and refer to clinical information, 1s touches ▎Clinical question: Is there a correlation between adipokines levels and the prognosis of rheumatoid arthritis (RA) patients?
After accounting for covariates, the highest quartile of adiponectin (compared with the lowest quartile) was associated with higher all-cause mortality (HR: 1.
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Science 'trained' memory cells in mouse gut
Time of Update: 2022-06-19
Collectively, this work identified a population of trained immune memory cells, Tr-ILC3s, in the mouse gut, which proliferated and rapidly produced IL-22 when re-encountered by pathogens after initial pathogen infection, thereby promoting mucosal defense .
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JEM Zhou Jie/Yao Zhi of Tianjin Medical University Reveal the Important Role of Lung renin Angiotensin System in Asthma
Time of Update: 2022-06-19
iNature type II innate lymphoid cells (ILC2s) have emerged as key mediators driving allergic airway inflammation .
Important role of lung epithelial cell-derived soluble factors in regulating ILC2 responses in allergic airway inflammation .
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Science｜Li Jing et al. discovered and identified CD8+ T cell subsets with regulatory functions in the human body
Time of Update: 2022-06-19
In conclusion, the authors discovered and identified a new subset of CD8+ T cells with regulatory functions in humans, which can selectively suppress pathogenic T cells that trigger autoimmune responses, thereby contributing to the maintenance of peripheral immune tolerance.
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Is Nature Lost Weight Loss Motivation?
Time of Update: 2022-06-19
In another model of AD induced with ovalbumin and papain, obese mice also showed more severe allergic airway responses, such as increased cellular infiltration across multiple immune subpopulations .
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Ankylosing spondylitis prone to fractures?
Time of Update: 2022-06-19
02Why are fractures in patients with ankylosing spondylitis easily overlooked?
Source of this article: rheumatism leap month said the editor in charge of this article: orange copyright statement This article is reprinted, welcome to forward the circle of friends~- End - Call for manuscripts "Rheumatology Immunity Channel in the Medical Community" long-term recruitment of online authors, 1.
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Science sub-journal: Xiang Qian/Wang Xiumei develops a hydrogel-delivered miRNA strategy for anti-aging treatment of osteoarthritis
Time of Update: 2022-06-19
Recently, the former team from Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine and the team of Wang Xiumei from the School of Materials Science and Technology of Tsinghua University jointly published an online publication in the journal Science Advances entitled: Stem cell-homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence Research paper in an osteoarthritis rat model (Stem cell homing hydrogel-based delivery of miR-29b-5p promotes cartilage regeneration by inhibiting aging) .
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Nature review: NK cells fight cancer, these development directions deserve attention
Time of Update: 2022-06-19
Strategies to Enhance NK Cell Function Cytokines that Stimulate NK Cells Antagonists of various activating or inhibitory cytokines are currently being evaluated in clinical trials .
The CD16/CD30-targeting bispecific antibody AFM13 developed by Affimed can also be used to pre-bind with NK cells in vitro to promote NK cell responses to CD30-positive lymphomas .
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Cell sub-issue: Zhu Yongqun's team and others reveal the mechanism of monoclonal antibody 35B5 neutralizing Omicron
Time of Update: 2022-06-19
The research paper by disrupting the N-glycan switch via a conserved Spike epitope reports that the full-spectrum human monoclonal antibody 35B5 of SARS-CoV-2 VOCs can potently neutralize Omicron and reveal its novel mechanism of action .
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"Rheumatoid Arthritis" asked ten times in a row, do you know the answer?
Time of Update: 2022-06-19
The most common symptoms of rheumatoid arthritis patients are joint pain and swelling, but the disease course and manifestations vary .
In the acute stage of pain in patients with rheumatoid arthritis, it is not recommended to exercise .
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In the initial treatment of "lupus nephritis", tacrolimus can replace cyclophosphamide!
Time of Update: 2022-06-19
Conduct large-scale clinical trials to supplement international research gaps Q medical community: On March 31, 2022, you published an article in JAMA Network Open on the efficacy and safety of tacrolimus combined with IVCY in the initial treatment of Chinese patients with LN of RCT study, could you please briefly describe the background of the study and what makes it unique?
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4 videos, walk into the latest progress in the treatment of refractory gout!
Time of Update: 2022-06-19
Refractory gout is the recurrent attack of acute gouty arthritis, which is characterized by the fact that conventional doses of uric acid-lowering drugs are difficult to make the blood uric acid reach the standard, manifested as chronic polyarthritis, destructive arthritis with tophi formation and/or uric acid Kidney stones .
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Overcoming ankylosing spondylitis, the current treatment of new progress
Time of Update: 2022-06-19
Based on the results of this trial, certolizumab became the only TNF inhibitor approved by the FDA for the treatment of nr-axSpA in the United States .
In a phase III study involving patients with axSpA, brodalumab was associated with ASAS40 responses in 43% compared to 24% in the placebo group .
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Are the side effects of cyclophosphamide preventable and reversible?
Time of Update: 2022-06-19
How to make good use of the sharp weapon - CTX in the treatment of rheumatism? Cyclophosphamide (CTX) is a broad-spectrum anti-tumor drug of alkylating agents. It is the strongest known immunosuppre
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A 17-year-old girl with lower extremity rash and acute kidney injury is actually because she is too loving?
Time of Update: 2022-06-18
Emergency urinalysis showed that the patient had acute blood proteinuria, serum creatinine of 128 μmol/L, spleen enlargement (19 cm), and ANCA PR3 was weakly positive in the initial immune test, suggesting the possibility of ANCA-related vasculitis .
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Nature Immunol type I cytokines cooperate to promote the body's inflammatory response
Time of Update: 2022-06-18
These data suggest that during the progression of chronic neuroinflammation, the MTPT process occurs in the central nervous system, and classical monocytes with high Ly6C expression accumulate at the site of inflammation through terminally differentiated inflammatory macrophages .
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Nature Metabolism Yang Weiwei/Zhao Yun/Yao Feng Reveal a New Mechanism of Pyruvate Dehydrogenase in Lung Cancer Immune Escape
Time of Update: 2022-06-17
In conclusion, in this study, we explored the role of PDH in tumor immune evasion and demonstrated that activated oncogenic signaling induces subcellular translocation of PDHE1α, thereby enhancing tumor cell resistance to immunotherapy, thereby promoting Development of lung cancer .
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【Literature Sharing】When SMARTer RACE and In-Fusion are used to prepare mAbs
Time of Update: 2022-06-17
This paper develops a robust high-throughput monoclonal antibody discovery and production system that integrates the advantages of efficient cloning and stable pool selection methods, reducing the time and effort required to clone and express large numbers of variable region genes, ranging from 4 to 6 months reduced to 4 to 6 weeks .
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The latest study: drinking one more day of coffee a week reduces the risk of gout by 25%!
Time of Update: 2022-06-17
Numerical values, including the number of days of coffee drinking per week, the risk of gout and the level of serum uric acid (SUA) were studied, and it was found that drinking coffee could help reduce the risk of gout.
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NATURE IMMUNOLOGY Blockbuster: Subverting the traditional understanding of immunogenic cell death
Time of Update: 2022-06-16
The article suggests the importance of immunogenic cell death in the etiology of non-infectious, non-malignant diseases related to self-reaction .
Regardless of the exact antigenic determinants of non-malignant, non-infectious diseases associated with autoreactivity, there is increasing evidence that ICDs and endogenous DAMPs are at least somewhat involved in the etiology of these diseases .
