The latest study: drinking one more day of coffee a week reduces the risk of gout by 25%!

*Read only for medical professionals.
Does coffee still have this effect? "Spring sleepiness, autumn sleepiness, summer naps", especially for migrant workers, often feel that they can't sleep, and a cup of coffee every day has become the standard
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Because of this, most people drink coffee not only to enjoy the delicious taste, but also to refresh the mind, and there may be family members who tell you to drink less coffee, because it is not a "healthy" drink in everyone's traditional perception
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For gout people who need various taboos, coffee is even more "out of reach" for them
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But is this really the case? Coffee and gout, in fact, have always been popular CP and the public imagined that the research on coffee and gout has always been very popular
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Harvard Medical School conducted a study on the relationship between coffee intake and gout risk in 2007 and 2010, respectively
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The former [1] included 45,869 men for a 12-year follow-up survey; the latter [2] included 89,433 women for a 26-year follow-up survey
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Both came to the same conclusion: coffee may reduce the risk of gout
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A review published in BMJ in 2016 [3] systematically analyzed all the studies on coffee and gout at that time, and this is even more confirmed
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 Although these studies have drawn conclusions, there has been no relevant statistical analysis and data support, which means that the relationship between coffee and gout is still worthy of further exploration
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 The latest research to report! Recently, a joint team from Japan's National Defense Medical University and Osaka University released a new study [4], which provides statistical support for the conclusion that "coffee reduces the risk of gout"
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Screenshots of the literature This study performed the first Mendelian randomization (MR) analysis of coffee-drinking patients with hyperuricemia and gout, and used genome-wide association statistics from the Japanese population for three studies of more than 150,000 subjects.
Numerical values, including the number of days of coffee drinking per week, the risk of gout and the level of serum uric acid (SUA) were studied, and it was found that drinking coffee could help reduce the risk of gout.
Mechanisms and prevention methods
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 It is worth mentioning that although previous studies have mentioned the relationship between coffee intake and gout risk: that is, compared with people who do not drink coffee, drink 1 to 3 cups of coffee per day (1 cup is 237ml) , the risk of gout was reduced by 22%; drinking four or more cups reduced the risk of gout by 57% [2]
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However, in this study in Japan, the relationship between gout risk and coffee intake was not emphasized, but the number of days of coffee drinking per week was focused, that is, each additional day of coffee consumption reduced the risk of gout by 25%
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 Why does drinking coffee reduce the risk of gout? First, let's understand two basic concepts: hyperuricemia and gout
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The former refers to a metabolic abnormal syndrome characterized by increased SUA levels caused by disturbances in purine metabolism
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When the level of SUA exceeds its saturation in blood or tissue, it can deposit and form sodium urate crystals in joints and other places, thereby inducing local inflammation and tissue destruction, that is, gout
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The caffeine in coffee, as a methylxanthine, can inhibit the enzyme (xanthine oxidase) required for the production of uric acid, thereby reducing the production of uric acid
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 Although coffee is good for preventing gout, people with gout should still avoid drinking too much coffee, because too much can lead to caffeine poisoning
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At the same time, excessive daily intake can easily lead to insomnia, heart palpitations and elevated blood pressure
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 Besides coffee, can gout sufferers drink other beverages? Having said so much about how coffee reduces the risk of gout, I believe that many gout sufferers are ready for coffee
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But some patients don't like coffee, so are there other options? Don’t worry, the editor will introduce it here~ Avoid alcohol and alcoholic beverages: The first thing that must be mentioned is the most common thing on the Chinese table: alcohol, which is significantly associated with an increased risk of gout
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The risk of gout caused by different alcohol is different, and the order from big to small is: beer, aged rice wine > spirits > dry red wine
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Beer, rice wine and other purine content are higher, and the more you drink, the higher the risk of gout [5]
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 Avoid sugar-sweetened beverages: Studies have found that the more sugar-sweetened beverages you drink, the higher your risk of developing gout
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Fructose, which is rich in sugar-sweetened beverages, promotes purine production and increases SUA levels
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 Dairy benefits: Studies show that people who drink milk once (or more times) a day have significantly lower levels of SUA than those who don't drink milk
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The study also found that people who consumed yogurt at least once every other day had significantly lower levels of SUA compared to those who did not consume yogurt [6]
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Compared with those who did not eat dairy products, those who regularly consumed dairy products had a 44% lower incidence of gout
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However, whole milk has a higher fat content, which may increase the risk of gout.
It is recommended that patients drink more low-fat milk
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 Drink plenty of water: For gout sufferers, urinating more than 2,000 milliliters per day can reduce the concentration of uric acid in the urine and the risk of uric acid kidney stones
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Patients should drink enough water every day to ensure urine output
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 Reference[1] Choi HK , Curhan G .
coffee consumption and risk of incident gout in women: the nurses health study 1-3[J].
2019.
[2] Choi HK , Willett W , Curhan G .
Coffee consumption and risk of incident gout in men - A prospective study[J].
Arthritis & Rheumatology, 2007, 56(6):2049-2055.
[3] Zhang Y , Yang T , Zeng C , et al.
Is coffee consumption associated with a lower risk of hyperuricaemia or gout? A systematic review and meta-analysis[J].
BMJ Open, 2016, 6(7):e009809.
[4] Zhang Y , Yang T , Zeng C , et al.
Is coffee consumption associated with a lower risk of hyperuricaemia or gout? A systematic review and meta-analysis[J].
BMJ Open, 2016, 6(7):e009809.
[5] You Hualing.
Four Avoidances and Five Benefits of Gout Diet[J].
Safety and Health, 2018 (7):1.
[6] Towiwat P , Li ZG .
The association of vitamin C, alcohol, coffee, tea, milk and yogurt with uric acid and gout[J].
International Journal of Rheumatic Diseases, 2015, 18(5):495-501.