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Science: Revising the findings of the textbook, Chen Chen's team confirmed that T cells also need rest and maintenance
Time of Update: 2022-08-12
The research team further identified the PILRα protein as a ligand for CD8α, disrupting the interaction between CD8α-PILRα, resulting in the inability of memory CD8+ T cells and naive CD8+ T cells to remain in a resting state, leading to their death .
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ARD: Osteoarthritis endotype identified by clustering of biochemical marker data
Time of Update: 2022-08-11
Biochemical markers reflecting joint tissue turnover were measured in the IMI-APPROACH cohort at baseline and analyzed using a machine learning approach to investigate the OA -dominant phenotype driven by endotype-related clusters and to discover driving characteristics and their disease context meaning .
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Br J Dermatol: Is heat shock protein 90 inhibition a relevant therapeutic strategy for psoriasis?
Time of Update: 2022-08-11
Br J Dermatol 2022 05;186(5) leave a message here In recent decades, several targeted therapies -- biologics and small molecules -- have been successfully developed and approved for the treatment of moderate-to-severe psoriasis vulgaris .
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The longer the course of the disease, the easier it is to relapse?
Time of Update: 2022-08-11
In general, lupus erythematosus relapses are preceded by the following symptoms:joint painJoint pain is not only a clinical manifestation at the onset of systemic lupus erythematosus, but also a sign of disease activity, with an incidence of 69 to 95% [2] .
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A&R: Diastolic dysfunction in systemic sclerosis: risk factors and impact on mortality
Time of Update: 2022-08-11
42054 Comment here Objectives: Primary cardiac involvement in systemic sclerosis (SSc) accounts for one-third of SSc -related deaths and traditionally includes conduction block, arrhythmia , and nonischemic cardiomyopathy .
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A&R: Extramucosal formation and prognostic value of secreted antibodies in rheumatoid arthritis
Time of Update: 2022-08-11
Objectives: Recent advances suggest that mucosal surfaces are important early in the development of rheumatoid arthritis (RA), especially in anti-citrullinated protein antibody (ACPA)-positive disease .
Rheumatoid Arthritis Studies in RA include levels of secreted Ig including ACPA and possible extramucosal formation .
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A&R: Therapeutic effects of cyclin-dependent kinase 4/6 inhibitors on skin fibrosis in a mouse model of systemic sclerosis
Time of Update: 2022-08-11
The purpose of this study was to 1) examine whether inhibition of the cell cycle with cyclin-dependent kinase 4/6 (CDK4/6) inhibitors would inhibit the proliferation of fibroblasts and their differentiation into myofibroblasts, and 2) evaluate Therapeutic effects of CDK4/6 inhibitors, administered as monotherapy or in combination with TGFβ receptor (TGFβR ) inhibitors , for the treatment of skin fibrosis in a mouse model of SSc .
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A&R: CD163+ M2 macrophages promote fibrosis in IgG4-related diseases via Toll-like receptor 7/IL-1 receptor-related kinase 4/NF-κB signaling pathway
Time of Update: 2022-08-11
CD163+ M2 macrophages promote fibrosis in IgG4-RD by increasing fibrotic cytokine production through TLR-7/IRAK4/NF - κB signaling .
CD163+ M2 macrophages promote fibrosis in IgG4-RD by increasing fibrotic cytokine production through TLR-7/IRAK4/NF - κB signaling .
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Should children with adenoid hypertrophy have abnormal coagulation?
Time of Update: 2022-08-11
The result is as follows:Through the APTT correction test, we preliminarily judged that the child's APTT was prolonged due to the interference of lupus anticoagulant and other substances; at the same time, we suggested that the child should be clinically tested for lupus anticoagulant and related antiphospholipid antibodies, and the test results showed lupus Anticoagulant was positive (SCT ratio 1.
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International Behcet's Disease Care Day: Progress of New Behcet's Disease Drugs
Time of Update: 2022-08-11
Table 1 Clinical characteristics of patients with Behcet's disease with macrovascular/cardiac involvement Another study [4] summarized the effects of tofacitinib in 13 patients with refractory BS and found that after an average follow-up of 8 months, the BS activity index was significantly improved, the inflammatory index was significantly reduced, and the amount of hormones used was significantly improved.
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5.10 World Lupus Day, an article summarizing how to fight wolves with science
Time of Update: 2022-08-11
guide The 2020 guidelines recommend that for mildly active SLE patients, only when hydroxychloroquine or non-steroidal anti-inflammatory drugs cannot control the disease, consider using low-dose corticosteroids (prednisone ≤ 10 mg/d or equivalent doses of other corticosteroids).
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Br J Dermatol: Systemic treatment of psoriasis is not just one network meta-analysis after another
Time of Update: 2022-08-11
In recent years, the number of systemic therapies, including biologics, for the treatment of psoriasis has rapidly increased, requiring up-to-date and comprehensive comparative effectiveness studies to aid clinical decision-making .
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A&R: Identification of shared and Asia-specific loci in systemic lupus erythematosus and evidence for a role for type III interferon signaling and lysosomal function in this disease: a multi-ancestry genome-wide association study
Time of Update: 2022-08-11
. Conclusions: In this study, shared and Asia-specific loci for SLE were identified, and functional annotation provided evidence for increased type III IFN signaling and decreased lysosomal functional involvement in SLE .
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A&R: Identification of similarities between skin lesions in patients with anti-synthetase syndrome and those in patients with dermatomyositis by highly multiplexed imaging mass flow cytometry
Time of Update: 2022-08-11
Given the presence of DM -like skin lesions in patients with ASyS , there is debate as to whether ASysS is a distinct disease or a subclass of DM .
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Nature: Gain-of-function genetic variation in TLR7 causes lupus in humans
Time of Update: 2022-08-11
TLR7 Nature left a comment While indirect evidence supports enhanced Toll -like receptor 7 (TLR7) signaling as a mechanism in human systemic autoimmune disease, evidence that TLR7 gene variants contribute to lupus is lacking .
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AJCD: How long does it take for psoriasis to return after stopping systemic therapy?
Time of Update: 2022-08-11
Am J Clin Dermatol 2022 Apr 30; Source: Masson Regnault M, Shourick J, Jendoubi F, Time to Relapse After Discontinuing Systemic Treatment for Psoriasis: A Systematic Review.
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5.10 These 7 SLE diagnosis and treatment traps on World Lupus Day, those who have stepped on them regretted it
Time of Update: 2022-08-11
Finally, I wish everyone It is precisely because systemic lupus erythematosus is a "difficult" disease that doctors and patients need to work together and use scientific diagnosis and treatment methods as weapons.
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New rheumatism medicine is here!
Time of Update: 2022-06-20
On April 6, the China National Medical Products Administration has approved upatinib for active psoriatic arthritis (PsA) in patients with poor response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs).
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Nature sub-journal: How to manage skin involvement in patients with systemic sclerosis?
Time of Update: 2022-06-20
In addition, these studies also found that the skin gene expression profile of patients with SSc changes over time and parallels the clinical progression of skin involvement [7-9] .
The most important thing is to optimize disease management strategies, especially symptomatic treatment and immunosuppression for patients with progressive skin involvement.
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Insights into human immunity from Omicron "Nature" long article
Time of Update: 2022-06-20
Preliminary data show that the current vaccine designed against the original strain of the new coronavirus is not effective in preventing Omicron infection, but appears to reduce hospitalization or mortality .
