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Nature: Gain-of-function genetic variation in TLR7 causes lupus in humans

 Last Update: 2022-08-11
 Source: Internet
 Author: User

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While indirect evidence supports enhanced Toll -like receptor 7 (TLR7) signaling as a mechanism in human systemic autoimmune disease, evidence that TLR7 gene variants contribute to lupus is lackin.

While indirect evidence supports enhanced Toll -like receptor 7 (TLR7) signaling as a mechanism in human systemic autoimmune disease, evidence that TLR7 TLR7 gene variants contribute to lupus is lackin.

TLR7 is a sensor of viral RNA that binds to guanosin.

This study identifies that TLR7 gain-of-function mutations can cause B cell-driven autoimmunity, including SLE , because of increased affinity for guanosine, resulting in a lower threshold for TLR7 activatio.

Source: Brown, GJ, Cañete, PF, Wang,.

Brown, GJ, Cañete, PF, Wang,.
et .
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