-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Written | Edited by Wang Cong | Typesetting by Wang Duoyu | Shui Chengwen biology textbook tells us that T cells are the soldiers of the immune system, always ready to deal with various threats from pathogenic microorganisms to tumo.
Among them, CD8+ T cells are the main effector cells in the immune system used to eliminate infectious pathogenic microorganisms and tumor cel.
A new study by Lieping's team published in the journal Science shows that if T cells are not rested and maintained, they may die quickly and make individuals more susceptible to pathoge.
The study, titled: The CD8α–PILRα interaction maintains CD8+ T cell quiescence, was published in the top international academic journal Science on May 26, 202This study shows that CD8α is essential for maintaining quiescent CD8+ T cells in peripheral lymphoid orga.
Deletion of CD8α results in spontaneous activation of naive CD8+ T cells and memory CD8+ T cells from a quiescent state and subsequent death without exposure to specific antige.
The study also found that PILRα is a ligand for CD8α, disrupting the CD8α-PILRα interaction and breaking the quiescent state of CD8+ T cel.
In the absence of antigen exposure, the CD8α-PILRα interaction actively maintains the peripheral T-cell repertoire and the quiescent state of CD8+ T cel.
This also suggests to us that CD8α-PILRα maintenance of the quiescent state of CD8+ T cells is necessary, and the lack of this maintenance of the quiescent state will lead to their dea.
Based on this finding, we may have to revise textbook T-cell biology, said Professor Lie Ping, who led the stu.
In addition to serving as a T-cell lineage marker, CD8 heterodimers also act as coreceptors to enhance T-cell receptor (TCR) signaling after antigen stimulati.
Whether CD8 exerts other antigen-independent functions is currently uncle.
T cells remain in a relatively quiescent state until a threat from pathogens or tumor cells is detect.
However, the molecular mechanisms that keep T cells in this inactive quiescent state remain unkno.
In this latest study, Yale University's Lieping team found that a protein called CD8α is present in CD8+ T cells in a subset of T cells, and its presence is critical for keeping CD8+ T cells in a quiescent sta.
CD8+ T cells are the main effector cells within the immune system used to eliminate infectious and tumor cells from pathogenic microorganis.
Chen Ping's research team constructed a conditional knockout CD8α mouse mod.
The CD8α deletion on peripheral CD8+ T cells of these mice did not affect the normal development of the thym.
The results showed that in the absence of CD8α, these protective CD8+ T cells were unable to enter a quiescent state and died quickly, leaving the mice vulnerable to infecti.
CD8a maintained memory CD8+ T cell quiescence, as well as peripheral CD127 and CD122 expressi.
The research team further identified the PILRα protein as a ligand for CD8α, disrupting the interaction between CD8α-PILRα, resulting in the inability of memory CD8+ T cells and naive CD8+ T cells to remain in a resting state, leading to their dea.
So why is this resting state critical for the maintenance and survival of T cells and improves immune system function? People tend to lose both naive and memory T cells as they age, making older adults more susceptible to infection, Lieping sa.
And the inability of T cells to remain quiescent may make people more susceptible to infection and canc.
Lie Ping, born in 1957, graduated from Fujian Medical University with a bachelor's degree in 1982, a master's degree from the Institute of Oncology, Chinese Academy of Medical Sciences in 1986, a .
After that, he worked at Bristol-Myers Squibb Company, Mayo Clinic, and Johns Hopkins Universi.
He joined Yale University in 2011 and is currently the Yale University UTC Cancer Research Chair Professor, Professor of Immunology, Medical Oncology and Dermatology, and Director of the Department of Immunology at Yale Cancer Cent.
Chen Lieping has long been engaged in the research of immunological mechanism, tumor immunotherapy and immune disease treatme.
Chen Lieping is the discoverer of PD-L1, who first revealed the role of the PD-L1/PD-1 pathway in immune escape from the tumor microenvironment, and pioneered the method of blocking the PD-1/PD-L1 pathway with antibodies to treat canc.
It is internationally renowned and has won many scientific awar.
In 2018, the Nobel Prize was awarded to James Allison of MD Anderson Cancer Center and Yumoto Honjo of Kyoto University, Japan, while Chen Ping did not win the award, which caused widespread controver.
Paper link: https:// Open for reprinting, welcome to forward to Moments and WeChat groups
Among them, CD8+ T cells are the main effector cells in the immune system used to eliminate infectious pathogenic microorganisms and tumor cel.
A new study by Lieping's team published in the journal Science shows that if T cells are not rested and maintained, they may die quickly and make individuals more susceptible to pathoge.
The study, titled: The CD8α–PILRα interaction maintains CD8+ T cell quiescence, was published in the top international academic journal Science on May 26, 202This study shows that CD8α is essential for maintaining quiescent CD8+ T cells in peripheral lymphoid orga.
Deletion of CD8α results in spontaneous activation of naive CD8+ T cells and memory CD8+ T cells from a quiescent state and subsequent death without exposure to specific antige.
The study also found that PILRα is a ligand for CD8α, disrupting the CD8α-PILRα interaction and breaking the quiescent state of CD8+ T cel.
In the absence of antigen exposure, the CD8α-PILRα interaction actively maintains the peripheral T-cell repertoire and the quiescent state of CD8+ T cel.
This also suggests to us that CD8α-PILRα maintenance of the quiescent state of CD8+ T cells is necessary, and the lack of this maintenance of the quiescent state will lead to their dea.
Based on this finding, we may have to revise textbook T-cell biology, said Professor Lie Ping, who led the stu.
In addition to serving as a T-cell lineage marker, CD8 heterodimers also act as coreceptors to enhance T-cell receptor (TCR) signaling after antigen stimulati.
Whether CD8 exerts other antigen-independent functions is currently uncle.
T cells remain in a relatively quiescent state until a threat from pathogens or tumor cells is detect.
However, the molecular mechanisms that keep T cells in this inactive quiescent state remain unkno.
In this latest study, Yale University's Lieping team found that a protein called CD8α is present in CD8+ T cells in a subset of T cells, and its presence is critical for keeping CD8+ T cells in a quiescent sta.
CD8+ T cells are the main effector cells within the immune system used to eliminate infectious and tumor cells from pathogenic microorganis.
Chen Ping's research team constructed a conditional knockout CD8α mouse mod.
The CD8α deletion on peripheral CD8+ T cells of these mice did not affect the normal development of the thym.
The results showed that in the absence of CD8α, these protective CD8+ T cells were unable to enter a quiescent state and died quickly, leaving the mice vulnerable to infecti.
CD8a maintained memory CD8+ T cell quiescence, as well as peripheral CD127 and CD122 expressi.
The research team further identified the PILRα protein as a ligand for CD8α, disrupting the interaction between CD8α-PILRα, resulting in the inability of memory CD8+ T cells and naive CD8+ T cells to remain in a resting state, leading to their dea.
So why is this resting state critical for the maintenance and survival of T cells and improves immune system function? People tend to lose both naive and memory T cells as they age, making older adults more susceptible to infection, Lieping sa.
And the inability of T cells to remain quiescent may make people more susceptible to infection and canc.
Lie Ping, born in 1957, graduated from Fujian Medical University with a bachelor's degree in 1982, a master's degree from the Institute of Oncology, Chinese Academy of Medical Sciences in 1986, a .
After that, he worked at Bristol-Myers Squibb Company, Mayo Clinic, and Johns Hopkins Universi.
He joined Yale University in 2011 and is currently the Yale University UTC Cancer Research Chair Professor, Professor of Immunology, Medical Oncology and Dermatology, and Director of the Department of Immunology at Yale Cancer Cent.
Chen Lieping has long been engaged in the research of immunological mechanism, tumor immunotherapy and immune disease treatme.
Chen Lieping is the discoverer of PD-L1, who first revealed the role of the PD-L1/PD-1 pathway in immune escape from the tumor microenvironment, and pioneered the method of blocking the PD-1/PD-L1 pathway with antibodies to treat canc.
It is internationally renowned and has won many scientific awar.
In 2018, the Nobel Prize was awarded to James Allison of MD Anderson Cancer Center and Yumoto Honjo of Kyoto University, Japan, while Chen Ping did not win the award, which caused widespread controver.
Paper link: https:// Open for reprinting, welcome to forward to Moments and WeChat groups
