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A&R: Identification of similarities between skin lesions in patients with anti-synthetase syndrome and those in patients with dermatomyositis by highly multiplexed imaging mass flow cytometry

 Last Update: 2022-08-11
 Source: Internet
 Author: User

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Objective: Anti-synthetase syndrome (ASyS) and dermatomyositis (DM) are clinically overlapping autoimmune diseas.

METHODS: Five patients with ASys and seven patients with DM were recruitedfrom a prospectively collected database of patients with definitively diagnosed D.

Results: IF staining of MxA and IFNβ expression showed that type I IFN was upregulated in ASyS and DM samples compared with healthy control samples ( P < 05 .

Conclusions: IMC is a powerful tool to identify the role of the type I IFN system in DM - like skin lesions in ASyS and D.

Source: Patel,.

Patel,.
, Ravishankar,.
, Maddukuri,.
, Vazquez,.
, Grinnell,.
and Werth, VP (2022), Identification of Similarities Between Skin Lesions in Patients With Antisynthetase Syndrome and Skin Lesions in Patients With Dermatomyositis by Highly Multiplexed Imaging Mass Cytomet.
Arthritis Rheumatol, 74: 882-89https://d.
org/11002/a.
42050 https://d.
org/11002/a.
42050Leave a comment here

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