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A&R: Therapeutic effects of cyclin-dependent kinase 4/6 inhibitors on skin fibrosis in a mouse model of systemic sclerosis

 Last Update: 2022-08-11
 Source: Internet
 Author: User

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Objective: One of the histological features of systemic sclerosis (SSc) is an increase in the number of dermal myofibroblasts, and transforming growth factor beta (TGF β ) plays a role in promoting the differentiation of fibroblasts into myofibroblasts and leading to dermal fibros.

Methods: Fibroblasts obtained from the skin of SSc patients were culturedin the presence or absence of TGF.

Results: Addition of CDK4/6 inhibitors to cell cultures inhibited the proliferation of human dermal SSc fibroblasts and their TGFβ -induced myofibroblast differentiation, but not both canonical and non-canonical TGFβ signalin.

Conclusions: The results of this study demonstrate the therapeutic efficacy of CDK4/6 inhibitors in skin fibrosis when used as monotherapy or in combination with TGFβR inhibitor.

Source: Yamamoto,.

Yamamoto,.
, Saito,.
, Hosoya,.
, Kawahata,.
, Asano,.
, Sato,.
, Mizoguchi,.
, Yasuda,.
and Kohsaka,.
(2022), Therapeutic Effect of Cyclin-Dependent Kinase 4/6 Inhibitor on Dermal Fibrosis in Murine Models of Systemic Scleros.
Arthritis Rheumatol, 74: 860-87https://d.

org/11002/a.

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