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Rheumatology: Renal fibroblasts are associated with interstitial fibrosis in lupus nephritis
Time of Update: 2022-08-15
The team investigated the presence and characteristics of fibroblasts in peripheral blood and kidneys of lupus nephritis (LN) patients , and the correlation of fibroblast abundance with renal tubular epithelial cells (RTECs) in LN fibrogenesis .
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Low back pain for 9 years is not as simple as "lumbar disc herniation"!
Time of Update: 2022-08-15
▎Case characteristics The patient was an elderly woman with a definite diagnosis of lumbar disc herniation, but the pain still aggravated after standard lumbar disc herniation treatment, and manifested as pain in multiple locations, acupuncture-like pain affecting sleep, diffuse The pain index was 8 points, and the disease severity score was 6 points .
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Eating "polyunsaturated fatty acids" like this can really control rheumatism!
Time of Update: 2022-08-15
The meta-analysis included 30 of 42 studies, with a total of 710 adult patients (RA, AS, PsA) receiving oral supplementation with omega-3 and/or omega-6 PUFAs; 710 controls were given placebo ;Compare the parameters of disease activity between the two groups: duration of morning stiffness (MS), visual analogue scale (VAS), DAS28, joint tenderness (TJC), joint swelling (SJC), Health Assessment Questionnaire (HAQ) score, red blood cells Sedimentation rate (ESR) and C-reactive protein (CRP) levels .
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Are inflammatory arthritis patients associated with higher mortality under the new crown epidemic?
Time of Update: 2022-08-15
Download the Doctor Station App and subscribe anytime, anywhere~ *Clinical information for medical professionals only, reachable in 1s ▎Clinical question: Does the treatment and isolation status of inflammatory arthritis (IA) patients affect the risk of adverse COVID-19 outcomes?
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Nat Chem Biol arginine methyltransferase regulates a novel mechanism of endogenous immunity in triple-negative breast cancer
Time of Update: 2022-08-15
On May 16, 2022, Wu Qin's team from the Institute of Basic Medicine and Oncology, Chinese Academy of Sciences, in collaboration with the University of Toronto, Canada, published a research paper titled PRMT inhibition triggers the viral mimicry response in Triple Negative Breast Cancer online in Nature Chemical Biology, revealing that The new mechanism of arginine methyltransferase regulating endogenous immunity provides a new strategy for the immunotherapy of triple-negative breast cancer .
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Can a ketogenic diet improve osteoarthritis?
Time of Update: 2022-08-15
Download the Doctor Station App and subscribe anytime, anywhere~ *For medical professionals to read and refer to clinical information, 1s touches ▎Clinical question: What protective mechanism does ketogenic diet (KD) use to improve osteoarthritis (OA)?
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How to monitor the therapeutic drug of rheumatism patients?
Time of Update: 2022-08-15
*For medical professionals only, 6 principles and 13 points to consider Therapeutic Drug Monitoring (TDM) of biopharmaceuticals refers to the use of biopharmaceutical blood drug concentrations and optional drug resistance antibodies (ADAb) to guide treatment decisions.
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Baricitinib: 80% hair regrowth in 40% of alopecia areata patients NEJM Review
Time of Update: 2022-08-15
The results showed that at week 36, baricitinib 4 The proportion of patients with 80% or more scalp hair coverage in the mg group was close to 40%, and the proportion of complete or almost complete regrowth of eyebrows and eyelashes was also close to 40% On May 5, 2022, the New England Journal of Medicine (NEJM) published two Phase 3 trials, BRAVE-AA1 and BRAVE-AA2, of oral baricitinib in the treatment of alopecia areata.
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A&R: Glutaminase 2 promotes CD4+ T cell production of interleukin 2 by supporting antioxidant defense in systemic lupus erythematosus
Time of Update: 2022-08-15
Finally, GLS2 overexpression corrected ROS levels and restored IL-2 production by CD4+ T cells in lupus-prone mice and SLE patients .
Finally, GLS2 overexpression corrected ROS levels and restored IL-2 production by CD4+ T cells in lupus-prone mice and SLE patients .
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Rheumatism symptoms are too complex?
Time of Update: 2022-08-15
Diagnosis of inflammation; lupus-related autoantibodies are positive, which is first considered to be caused by systemic lupus erythematosus For this case, the supporting evidence for verrucous endocarditis is: the patient has no history of fever; the blood picture and classification are not high, no toxic particles are found in the bone marrow, and the blood culture is negative; there is no fresh microembolism, and the infective endocardium is not supported.
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Huazhong Agricultural University Han Wenyuan's team discovered a new mechanism for the prokaryotic Argonaute system to mediate immune response Cell Press Dialogue with scientists
Time of Update: 2022-08-15
Life science On May 19, 2022, the team of Han Wenyuan from Huazhong Agricultural University published the research results of analyzing the immune function of the new prokaryotic Argonaute (Ago) system in the form of Article in the journal Cell Host & Microbe .
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Br J Dermatol: Dupilumab is effective in improving symptoms and signs in patients with atopic dermatitis
Time of Update: 2022-08-12
The efficacy and safety of dupilumab in Chinese patients with moderate-to-severe atopic dermatitis: a randomized, double-blind, controlled study leave a message here Dupilumab is an antibody against interleukin-4 receptor alpha used to treat atopic dermatitis (AD) .
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A&R: A risk score for detecting subclinical rheumatoid arthritis-associated interstitial lung disease
Time of Update: 2022-08-12
. Conclusions: This study identifies and validates a risk score for RA-ILD with or without MUC5B rs35705950 that identifies patients at high risk for subclinical RA-ILD requiring screening with chest HRCT scans .
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A&R: In vivo multidimensional immunoassay of cutaneous lupus erythematosus stratified by patient response to antimalarial drugs
Time of Update: 2022-08-12
and Werth, VP (2022), Multidimensional immune profiling of cutaneous lupus erythematosus in vivo stratified by patient responses to antimalarials.
and Werth, VP (2022), Multidimensional immune profiling of cutaneous lupus erythematosus in vivo stratified by patient responses to antimalarials.
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ARD: Induced antibodies to the angiotensin receptor type 1 trigger cross-species skin and lung inflammation and dermal fibrosis
Time of Update: 2022-08-12
1136 /annrheumdis-2021-222088 , et al Annals of the Rheumatic Diseases leave a message here Objective: Angiotensin receptor type 1 (AT1R, AGTR1) is a G protein-coupled receptor (GPCR) that is mainly involved in the regulation of vascular tone, vascular smooth muscle cell proliferation, extracellular matrix production and inflammation .
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Lancet rheumatology: Humoral responses after second and third SARS-CoV-2 vaccination with immunosuppressive agents in patients with immune-mediated inflammatory diseases: a cohort study
Time of Update: 2022-08-12
OBJECTIVE : A disease-specific study reported impaired humoral responses following SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases treated with specific immunosuppressants .
OBJECTIVE : A disease-specific study reported impaired humoral responses following SARS-CoV-2 vaccination in patients with immune-mediated inflammatory diseases treated with specific immunosuppressants .
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A&R: Association of body mass index with pain and the mediating role of inflammatory biomarkers in patients with osteoarthritis of the hand
Time of Update: 2022-08-12
42056 Leave a comment here Objectives: To investigate the association of body mass index (BMI) with pain in patients with osteoarthritis (OA) of the hand , and to explore whether this association, if causal, is mediated by systemic inflammatory biomarkers .
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Why does gout prefer men?
Time of Update: 2022-08-12
Most of these foods contain relatively High purine values may lead to elevated blood uric acid;Relatively speaking, many female friends have many “taboos” in their diet in order to keep a good figure, while men usually socialize at work and have a lot of parties, and like to eat all kinds of meat, seafood, animal offal, etc.
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How should we put hormones in perspective?
Time of Update: 2022-08-12
When it comes to hormones, just like when it comes to stocks, most people love it and fear it . I hope it works, but I'm afraid it will hurt myself . When it comes to hormones, just like when it comes
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ARD: Risk of cardiovascular events in patients with acute calcium pyrophosphate crystal arthritis
Time of Update: 2022-08-12
Sensitivity analysis included: ( 1 ) Acute CPP diagnosed at outpatient visitPatients with crystal arthritis, ( 2 ) patients with relevant Medicare data, 2007-2016 and ( 3 ) patients matched on the number of CV risk factors .
