-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
*For medical professionals to read and reference this kind of pain is not ea.
The "International Fibromyalgia Day" theme event organized by the Psychosomatic Rheumatology Group of the Psychosomatic Medicine Branch of the Chinese Medical Association was successfully held onli.
Diseases were discussed vigorous.
Among them, Xu Xiaoyan, deputy chief physician of the Department of Rheumatology and Immunology, Zhongda Hospital Affiliated to Southeast University, explained the diagnosis and treatment of FM in detail based on clinical cas.
Lumbar disc herniation, why is the pain difficult to relieve after treatment? ▎Case Introduction A 76-year-old female patient was admitted to the hospital mainly because of "9 years of waist and hip pai.
The patient developed waist and buttock pain 9 years ago, accompanied by pain in the sternum and ri.
The local hospital considered it as "lumbar disc herniatio.
The oral drug treatment was not effecti.
The pain gradually involved the whole abdomen, vulva, and anus, and occasionally accompanied by acupuncture-like pain in the ba.
, affecting sleep at nig.
Before 7 months, the symptoms worsened, with persistent soreness and pain in both lower extremiti.
In the pain department of another hospital, it was considered as "lumbar disc herniation and osteoporosi.
Zoledronic acid was used for anti-osteoporosis, percutaneous ozone decompression of intervertebral disc, and intervertebral di.
Minimally invasive ablation, pain improved and discharg.
Before 6 months, the symptoms worsened again, and she was treated with "tramadol and gabapentin" in the pain department of another hospital, and the pain improved slight.
One month ago, the symptoms worsened again and underwent percutaneous radiofrequency annuloplasty under local anesthes.
Now the pain is getting worse, and she is admitted to the hospital because of severe sleep disturban.
■ Laboratory examination and disease score No abnormality in blood routine, biochemistry, CRP, ESR, autoantibodies, RF, HLA-B27 were negative; bone mineral density measurement: lumbar spine T-8, hip T-5; pain VAS score 7 8 points; diffuse pain index (WPI) 8 points; disease severity (SSS) score 6 poin.
▎Case characteristics The patient was an elderly woman with a definite diagnosis of lumbar disc herniation, but the pain still aggravated after standard lumbar disc herniation treatment, and manifested as pain in multiple locations, acupuncture-like pain affecting sleep, diffuse The pain index was 8 points, and the disease severity score was 6 poin.
▎Treatment and prognosis The patient's case characteristics meet the diagnostic criteria of FM, so the diagnosis of lumbar disc herniation combined with FM is ma.
On the basis of the original treatment, pregabalin 75 mg bid was added to improve sleep, and the pain gradually eased after two weeks of treatme.
Deputy Chief Physician Xu Xiaoyan pointed out that for rheumatic immune diseases, FM has a high comorbidity rate, and FM does not emphasize separate diagnos.
In this patient, the pain of osteoporosis and lumbar disc herniation was not relieved after standard treatment, so the possibility of FM should be consider.
Do you know FM? FM is a chronic (>3 months), non-inflammatory, non-autoimmune diffuse pain syndrome caused by dysfunctional central afferent processi.
Its core symptoms include pain in multiple locations, severe fatigue, stiffness, sleep disturbance, cognitive problems, and often psychological distre.
▎Clinical featuresPain and tenderness Widespread pain is the main feature of .
The pain is diffuse and difficult to locate accurate.
The pain is of various nature, ranging from mild to severe, and is often not relieved by re.
Inappropriate activities and exercise can make symptoms wor.
The only reliable sign of FM is the symmetrical distribution of tender points throughout the bo.
At the tender point, the patient is very sensitive to the "pressing" reaction, and there will be a painful expression or defensive reactions such as resisting pressure and retreati.
Physical symptoms: muscle pain, muscle weakness, weakness/fatigue, fever; Raynaud's phenomenon, wheal, rash, photosensitivity, easy ecchymosis, itching, hair loss, dry mouth, mouth ulcers, taste changes, dry eyes, visual acuity Unclear; loss of appetite, nausea, vomiting, heartburn, epigastric pain, abdominal pain/cramping, diarrhea, constipation, irritable bowel syndrome, chest pain, stridor, suffocation; headache, numbness, dizziness, convulsions, tinnitus, hearing impairment, insomnia , depression, nervousness, thinking or memory problems; increased urination, difficulty urinating, and bladder spas.
▎Diagnosis Figure 1: Key points of FM diagnosis In 2016, ACR's diagnostic criteria for FM were: WPI≥7+SSS≥5 or WPI4-6+SSS≥9; generalized pain, defined as at least 4 pains in 5 areas , jaw, chest, and abdominal pain are not included in the generalized pain definition (5 areas: left upper extremity, right upper extremity, left lower extremity, right lower extremity, mid-axis area); symptoms usually persist for at least 3 months; FM is diagnosed when all 3 are prese.
It should be noted that the diagnosis of FM does not conflict with the diagnosis of other diseas.
In addition, the FIRST scale facilitates rapid screening of .
Table 1: FIRST scale▎Pathogenesis Figure 2: Pathogenesis of FM Functional MRI showed sensory activation in pain areas of the central nervous system in patients with .
Central sensitization is the core pathogenesis of FM [
When the body is subjected to external stimuli, such as noxious stimuli, trauma, stress, disease, e.
, the pain signal ascends along the spinal cord and reaches the cerebral cortex, and the signal is regulated down to inhibit pa.
However, when the ascending pathway is abnormally excited or the inhibitory effect of the descending pathway is weakened, the center is more sensitive to the perception of pain, and it is difficult to suppress the pain, so that the pain persists and sprea.
This phenomenon is called central sensitizati.
A 2017 study showed [2] that 47% of inflammatory arthritis included rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, and central sensitization at the same ti.
FM is often comorbid with rheumatic immune diseases and has serious ha.
Studies have shown that [3], 1/6 to 1/2 of rheumatic immune diseases are complicated by FM, and the accompanying FM will increase the disease activi.
Summary FM is a chronic, non-inflammatory, diffuse pain syndrome caused by dysfunctional central afferent processi.
Deputy Chief Physician Xu Xiaoyan gave a comprehensive introduction to the diagnosis and mechanism of FM based on clinical cas.
He described the typical cases of FM combined with organic diseases, and it was not easy to identify the combination of lumbar disc herniation and .
It requires extensive clinical experience, a solid understanding of FM, and a keen e.
Deputy Chief Physician Xu Xiaoyan's wonderful explanation unraveled the mystery of FM for us, and pointed out the direction for improving the diagnosis rate of FM by rheumatologis.
Expert Profile Xu Xiaoyan, Deputy Chief Physician, Deputy Chief Physician, Chief Physician, Department of Rheumatology and Immunology, Zhongda Hospital Affiliated to Southeast University, Deputy Chief Physician, MD, Master Supervisor Vice-chairman of the Department of Diseases, Member of the Rheumatology and Immunity Branch of the Jiangsu Association of Integrative Medicine, Member of the Rheumatism Infection Group of the Cross-Strait Exchange Society References: [1] Chinn,.
,.
Caldwell, and.
Gritsenko, Fibromyalgia Pathogenesis and Treatment Options Upda.
Curr Pain Headache Rep, 201 20(4):.
2 [2]RifbjergMadsen,.
, et .
, Psychometric properties of the painDETECT in rheumatoid arthritis, psoriatic arthritis and spondyloarthritis: Rasch analysis and test- retest reliabili.
Health Qual Life Outcomes, 201 15(1):.
11[3]Fitzcharles, MA,.
Perrot, and.
Häuser, Comorbid fibromyalgia: A qualitative review of prevalence and importan.
Eur J Pain, 201 22(9):.
1565-157
The "International Fibromyalgia Day" theme event organized by the Psychosomatic Rheumatology Group of the Psychosomatic Medicine Branch of the Chinese Medical Association was successfully held onli.
Diseases were discussed vigorous.
Among them, Xu Xiaoyan, deputy chief physician of the Department of Rheumatology and Immunology, Zhongda Hospital Affiliated to Southeast University, explained the diagnosis and treatment of FM in detail based on clinical cas.
Lumbar disc herniation, why is the pain difficult to relieve after treatment? ▎Case Introduction A 76-year-old female patient was admitted to the hospital mainly because of "9 years of waist and hip pai.
The patient developed waist and buttock pain 9 years ago, accompanied by pain in the sternum and ri.
The local hospital considered it as "lumbar disc herniatio.
The oral drug treatment was not effecti.
The pain gradually involved the whole abdomen, vulva, and anus, and occasionally accompanied by acupuncture-like pain in the ba.
, affecting sleep at nig.
Before 7 months, the symptoms worsened, with persistent soreness and pain in both lower extremiti.
In the pain department of another hospital, it was considered as "lumbar disc herniation and osteoporosi.
Zoledronic acid was used for anti-osteoporosis, percutaneous ozone decompression of intervertebral disc, and intervertebral di.
Minimally invasive ablation, pain improved and discharg.
Before 6 months, the symptoms worsened again, and she was treated with "tramadol and gabapentin" in the pain department of another hospital, and the pain improved slight.
One month ago, the symptoms worsened again and underwent percutaneous radiofrequency annuloplasty under local anesthes.
Now the pain is getting worse, and she is admitted to the hospital because of severe sleep disturban.
■ Laboratory examination and disease score No abnormality in blood routine, biochemistry, CRP, ESR, autoantibodies, RF, HLA-B27 were negative; bone mineral density measurement: lumbar spine T-8, hip T-5; pain VAS score 7 8 points; diffuse pain index (WPI) 8 points; disease severity (SSS) score 6 poin.
▎Case characteristics The patient was an elderly woman with a definite diagnosis of lumbar disc herniation, but the pain still aggravated after standard lumbar disc herniation treatment, and manifested as pain in multiple locations, acupuncture-like pain affecting sleep, diffuse The pain index was 8 points, and the disease severity score was 6 poin.
▎Treatment and prognosis The patient's case characteristics meet the diagnostic criteria of FM, so the diagnosis of lumbar disc herniation combined with FM is ma.
On the basis of the original treatment, pregabalin 75 mg bid was added to improve sleep, and the pain gradually eased after two weeks of treatme.
Deputy Chief Physician Xu Xiaoyan pointed out that for rheumatic immune diseases, FM has a high comorbidity rate, and FM does not emphasize separate diagnos.
In this patient, the pain of osteoporosis and lumbar disc herniation was not relieved after standard treatment, so the possibility of FM should be consider.
Do you know FM? FM is a chronic (>3 months), non-inflammatory, non-autoimmune diffuse pain syndrome caused by dysfunctional central afferent processi.
Its core symptoms include pain in multiple locations, severe fatigue, stiffness, sleep disturbance, cognitive problems, and often psychological distre.
▎Clinical featuresPain and tenderness Widespread pain is the main feature of .
The pain is diffuse and difficult to locate accurate.
The pain is of various nature, ranging from mild to severe, and is often not relieved by re.
Inappropriate activities and exercise can make symptoms wor.
The only reliable sign of FM is the symmetrical distribution of tender points throughout the bo.
At the tender point, the patient is very sensitive to the "pressing" reaction, and there will be a painful expression or defensive reactions such as resisting pressure and retreati.
Physical symptoms: muscle pain, muscle weakness, weakness/fatigue, fever; Raynaud's phenomenon, wheal, rash, photosensitivity, easy ecchymosis, itching, hair loss, dry mouth, mouth ulcers, taste changes, dry eyes, visual acuity Unclear; loss of appetite, nausea, vomiting, heartburn, epigastric pain, abdominal pain/cramping, diarrhea, constipation, irritable bowel syndrome, chest pain, stridor, suffocation; headache, numbness, dizziness, convulsions, tinnitus, hearing impairment, insomnia , depression, nervousness, thinking or memory problems; increased urination, difficulty urinating, and bladder spas.
▎Diagnosis Figure 1: Key points of FM diagnosis In 2016, ACR's diagnostic criteria for FM were: WPI≥7+SSS≥5 or WPI4-6+SSS≥9; generalized pain, defined as at least 4 pains in 5 areas , jaw, chest, and abdominal pain are not included in the generalized pain definition (5 areas: left upper extremity, right upper extremity, left lower extremity, right lower extremity, mid-axis area); symptoms usually persist for at least 3 months; FM is diagnosed when all 3 are prese.
It should be noted that the diagnosis of FM does not conflict with the diagnosis of other diseas.
In addition, the FIRST scale facilitates rapid screening of .
Table 1: FIRST scale▎Pathogenesis Figure 2: Pathogenesis of FM Functional MRI showed sensory activation in pain areas of the central nervous system in patients with .
Central sensitization is the core pathogenesis of FM [
When the body is subjected to external stimuli, such as noxious stimuli, trauma, stress, disease, e.
, the pain signal ascends along the spinal cord and reaches the cerebral cortex, and the signal is regulated down to inhibit pa.
However, when the ascending pathway is abnormally excited or the inhibitory effect of the descending pathway is weakened, the center is more sensitive to the perception of pain, and it is difficult to suppress the pain, so that the pain persists and sprea.
This phenomenon is called central sensitizati.
A 2017 study showed [2] that 47% of inflammatory arthritis included rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, and central sensitization at the same ti.
FM is often comorbid with rheumatic immune diseases and has serious ha.
Studies have shown that [3], 1/6 to 1/2 of rheumatic immune diseases are complicated by FM, and the accompanying FM will increase the disease activi.
Summary FM is a chronic, non-inflammatory, diffuse pain syndrome caused by dysfunctional central afferent processi.
Deputy Chief Physician Xu Xiaoyan gave a comprehensive introduction to the diagnosis and mechanism of FM based on clinical cas.
He described the typical cases of FM combined with organic diseases, and it was not easy to identify the combination of lumbar disc herniation and .
It requires extensive clinical experience, a solid understanding of FM, and a keen e.
Deputy Chief Physician Xu Xiaoyan's wonderful explanation unraveled the mystery of FM for us, and pointed out the direction for improving the diagnosis rate of FM by rheumatologis.
Expert Profile Xu Xiaoyan, Deputy Chief Physician, Deputy Chief Physician, Chief Physician, Department of Rheumatology and Immunology, Zhongda Hospital Affiliated to Southeast University, Deputy Chief Physician, MD, Master Supervisor Vice-chairman of the Department of Diseases, Member of the Rheumatology and Immunity Branch of the Jiangsu Association of Integrative Medicine, Member of the Rheumatism Infection Group of the Cross-Strait Exchange Society References: [1] Chinn,.
,.
Caldwell, and.
Gritsenko, Fibromyalgia Pathogenesis and Treatment Options Upda.
Curr Pain Headache Rep, 201 20(4):.
2 [2]RifbjergMadsen,.
, et .
, Psychometric properties of the painDETECT in rheumatoid arthritis, psoriatic arthritis and spondyloarthritis: Rasch analysis and test- retest reliabili.
Health Qual Life Outcomes, 201 15(1):.
11[3]Fitzcharles, MA,.
Perrot, and.
Häuser, Comorbid fibromyalgia: A qualitative review of prevalence and importan.
Eur J Pain, 201 22(9):.
1565-157
