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*Read Only For Medical Professionals Reference Strange Knowledge Added Over the past 20 years, the diagnosis and treatment of rheumatoid arthritis (RA) and other inflammatory rheumatic diseases (IRDs) has improved dramatical.
Nonetheless, there are still unmet needs for patients, and an increasing number of patients require alternative therapy as a supplement to traditional synthetic disease-modifying antirheumatic dru.
Therefore, the role of diet has received increasing attention, however, researching the potential effects of diet remains a great challenge due to the complexity and diversity of dietary componen.
Unlike trials on Mediterranean, vegan, and gluten-free diets, randomized controlled trials (RCTs) of polyunsaturated fatty acid (PUFA) supplementation in patients with IRD are of high quali.
PUFAs can be classified into ω-3 and ω-6 PUFAs according to the position of the first double bond from the methyl e.
Multiple studies have reported that PUFA supplementation improves disease activity in I.
However, the study was not large enough and the conclusions remain controversi.
Oral omega-3 PUFA>2g/day significantly improves disease activity This systematic literature review and meta-analysis[1] recently published in Arthritis Research & Therapy aimed to better evaluate oral supplementation of omega-3 and omega-6 Effects of PUFAs on the duration, dose, type and source of IRD activi.
The meta-analysis included 30 of 42 studies, with a total of 710 adult patients (RA, AS, PsA) receiving oral supplementation with omega-3 and/or omega-6 PUFAs; 710 controls were given placebo ;Compare the parameters of disease activity between the two groups: duration of morning stiffness (MS), visual analogue scale (VAS), DAS28, joint tenderness (TJC), joint swelling (SJC), Health Assessment Questionnaire (HAQ) score, red blood cells Sedimentation rate (ESR) and C-reactive protein (CRP) leve.
▎Results:Overall effect of PUFA supplementation on disease activity Oral PUFA supplementation significantly improved clinical parameters of disease activity in patien.
Significant improvement in VAS activity score; moderate improvement in VAS pain score, DAS28, and HAQ score; lower improvement in MS duration, SJC, and TJC (Table
It should be noted that the above improvement results are all after 3 months and 6 months of oral PU.
Table 1 Effects of oral PUFA supplementation on IRD activity parameters compared with controls After 3 PUFA, all parameters except SJC, VAS pain score and CRP level were significantly improv.
Supplementation with omega-6 PUFAs significantly reduced SJC, VAS activity, and HAQ scores (Figure
Figure 1 Effect of PUFA type (omega-3 or omega-6) on RA disease activity , VAS activity, MS duration, HAQ scores, CRP levels, and ESR, but did not significantly reduce SJC, DAS28, or VAS pain scor.
In contrast, plant-derived PUFA supplementation significantly reduced SJC, VAS activity, and HAQ scores on.
Subgroup analysis of the effect of oral PUFA at different doses on RA disease activity showed that high-dose PUFA supplementation (≥2g/day) significantly reduced TJC, VAS activity score, MS duration, DA28, HAQ score and ESR, But it did not reduce SJC, VAS pain score or CRP leve.
Low-dose PUFA supplementation (<2 g/day) only significantly reduced CRP leve.
The above conclusions may seem complicat.
In general, PUFA intake can improve multiple disease activity parameters in IRD patients, especially ω-3>2g/day from animal sources, which may be an adjuvant therapy for .
Understood! It turns out that PUFAs are really good for improving disease activity in IRD patients! At this time, a little friend wants to ask, it seems that I heard that PUFA has some other functions, yes! What are the diverse roles of PUFAs? PUFAs are an important part of the di.
The dietary source of omega-3 PUFAs is fish, and the two most important unsaturated fatty acids in omega-3 PUFAs are DHA and E.
EPA is the English abbreviation of eicosapentaenoic acid, which has the function of cleaning up the garbage (cholesterol and triglyceride) in the blood vessels, commonly known as "vascular scavenge.
DHA is the English abbreviation of docosahexaenoic acid, which has the functions of softening blood vessels, strengthening brain and improving eyesight, commonly known as "brain gol.
It appears that in addition to the effect on disease activity, PUFA supplementation may be beneficial in reducing cardiovascular disea.
A meta-analysis reported the beneficial effects of PUFA supplementation (≥2 g/day) on cardiovascular disease [However, the evidence for high doses (2-4 g/day) is weaker than that for low doses, and the beneficial effect of omega-3 PUFAs on cardiovascular risk is still controversial [
In addition, several studies have found that omega-3 PUFAs have effects on osteoporosis, prenatal health, depression, and mo.
The main dietary sources of omega-6 PUFAs are vegetable oils and animals, the major constituents of which are linoleic acid and arachidonic ac.
Omega-6 PUFA has the effect of inhibiting and stimulating the immune response of human cells, and can improve lipid metabolism, lower blood sugar, prevent arteriosclerosis, reduce body fat, and enhance immune functi.
However, omega-6 PUFAs also have pro-inflammatory effects, with a major fraction of arachidonic acid-derived compounds acting as inflammatory mediators, arachidonic acid acting through the action of cyclooxygenases, prostaglandins and thromboxanes, and lipoxygenases The role of leukotrienes [
Prostaglandins can lead to increased vascular permeability, tissue fibrosis, increased expression of adhesion molecules and leukocyte migration in inflamed tissues [Knowing the benefits of PUFA, how to get it from food? Ranking table of foods with high PUFA content▎ Edible oil Figure 2: Ranking of PUFA content in edible oil (Photo source: https:// sort-single-nutrition/pufas) ▎Fish Figure 3: Ranking of PUFA content in fish (Image source: https:// ▎Vegetable Figure 4: Vegetables PUFA content ranking (image source: https://▎Fruit Figure 5: PUFA content ranking in fruit (image source: https:// /sort/sort-single-nutrition/pufas) ▎ Nuts Figure 6: Ranking of PUFA content in nuts (Image source: https:// You can control what you eat Rheumatism, not to mention the benefits of PUFA supplementation! Why don't you act quickly? Just start with breakfast tomorrow! Reference [1] Sigaux et .
Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis, Arthritis Research & Therapy (2022) 24:100 https:/ /d.
org/11186/s13075-022-02781-2[2]Rizos EC, Markozannes G, Tsapas A, Mantzoros CS, Ntzani .
Nonetheless, there are still unmet needs for patients, and an increasing number of patients require alternative therapy as a supplement to traditional synthetic disease-modifying antirheumatic dru.
Therefore, the role of diet has received increasing attention, however, researching the potential effects of diet remains a great challenge due to the complexity and diversity of dietary componen.
Unlike trials on Mediterranean, vegan, and gluten-free diets, randomized controlled trials (RCTs) of polyunsaturated fatty acid (PUFA) supplementation in patients with IRD are of high quali.
PUFAs can be classified into ω-3 and ω-6 PUFAs according to the position of the first double bond from the methyl e.
Multiple studies have reported that PUFA supplementation improves disease activity in I.
However, the study was not large enough and the conclusions remain controversi.
Oral omega-3 PUFA>2g/day significantly improves disease activity This systematic literature review and meta-analysis[1] recently published in Arthritis Research & Therapy aimed to better evaluate oral supplementation of omega-3 and omega-6 Effects of PUFAs on the duration, dose, type and source of IRD activi.
The meta-analysis included 30 of 42 studies, with a total of 710 adult patients (RA, AS, PsA) receiving oral supplementation with omega-3 and/or omega-6 PUFAs; 710 controls were given placebo ;Compare the parameters of disease activity between the two groups: duration of morning stiffness (MS), visual analogue scale (VAS), DAS28, joint tenderness (TJC), joint swelling (SJC), Health Assessment Questionnaire (HAQ) score, red blood cells Sedimentation rate (ESR) and C-reactive protein (CRP) leve.
▎Results:Overall effect of PUFA supplementation on disease activity Oral PUFA supplementation significantly improved clinical parameters of disease activity in patien.
Significant improvement in VAS activity score; moderate improvement in VAS pain score, DAS28, and HAQ score; lower improvement in MS duration, SJC, and TJC (Table
It should be noted that the above improvement results are all after 3 months and 6 months of oral PU.
Table 1 Effects of oral PUFA supplementation on IRD activity parameters compared with controls After 3 PUFA, all parameters except SJC, VAS pain score and CRP level were significantly improv.
Supplementation with omega-6 PUFAs significantly reduced SJC, VAS activity, and HAQ scores (Figure
Figure 1 Effect of PUFA type (omega-3 or omega-6) on RA disease activity , VAS activity, MS duration, HAQ scores, CRP levels, and ESR, but did not significantly reduce SJC, DAS28, or VAS pain scor.
In contrast, plant-derived PUFA supplementation significantly reduced SJC, VAS activity, and HAQ scores on.
Subgroup analysis of the effect of oral PUFA at different doses on RA disease activity showed that high-dose PUFA supplementation (≥2g/day) significantly reduced TJC, VAS activity score, MS duration, DA28, HAQ score and ESR, But it did not reduce SJC, VAS pain score or CRP leve.
Low-dose PUFA supplementation (<2 g/day) only significantly reduced CRP leve.
The above conclusions may seem complicat.
In general, PUFA intake can improve multiple disease activity parameters in IRD patients, especially ω-3>2g/day from animal sources, which may be an adjuvant therapy for .
Understood! It turns out that PUFAs are really good for improving disease activity in IRD patients! At this time, a little friend wants to ask, it seems that I heard that PUFA has some other functions, yes! What are the diverse roles of PUFAs? PUFAs are an important part of the di.
The dietary source of omega-3 PUFAs is fish, and the two most important unsaturated fatty acids in omega-3 PUFAs are DHA and E.
EPA is the English abbreviation of eicosapentaenoic acid, which has the function of cleaning up the garbage (cholesterol and triglyceride) in the blood vessels, commonly known as "vascular scavenge.
DHA is the English abbreviation of docosahexaenoic acid, which has the functions of softening blood vessels, strengthening brain and improving eyesight, commonly known as "brain gol.
It appears that in addition to the effect on disease activity, PUFA supplementation may be beneficial in reducing cardiovascular disea.
A meta-analysis reported the beneficial effects of PUFA supplementation (≥2 g/day) on cardiovascular disease [However, the evidence for high doses (2-4 g/day) is weaker than that for low doses, and the beneficial effect of omega-3 PUFAs on cardiovascular risk is still controversial [
In addition, several studies have found that omega-3 PUFAs have effects on osteoporosis, prenatal health, depression, and mo.
The main dietary sources of omega-6 PUFAs are vegetable oils and animals, the major constituents of which are linoleic acid and arachidonic ac.
Omega-6 PUFA has the effect of inhibiting and stimulating the immune response of human cells, and can improve lipid metabolism, lower blood sugar, prevent arteriosclerosis, reduce body fat, and enhance immune functi.
However, omega-6 PUFAs also have pro-inflammatory effects, with a major fraction of arachidonic acid-derived compounds acting as inflammatory mediators, arachidonic acid acting through the action of cyclooxygenases, prostaglandins and thromboxanes, and lipoxygenases The role of leukotrienes [
Prostaglandins can lead to increased vascular permeability, tissue fibrosis, increased expression of adhesion molecules and leukocyte migration in inflamed tissues [Knowing the benefits of PUFA, how to get it from food? Ranking table of foods with high PUFA content▎ Edible oil Figure 2: Ranking of PUFA content in edible oil (Photo source: https:// sort-single-nutrition/pufas) ▎Fish Figure 3: Ranking of PUFA content in fish (Image source: https:// ▎Vegetable Figure 4: Vegetables PUFA content ranking (image source: https://▎Fruit Figure 5: PUFA content ranking in fruit (image source: https:// /sort/sort-single-nutrition/pufas) ▎ Nuts Figure 6: Ranking of PUFA content in nuts (Image source: https:// You can control what you eat Rheumatism, not to mention the benefits of PUFA supplementation! Why don't you act quickly? Just start with breakfast tomorrow! Reference [1] Sigaux et .
Impact of type and dose of oral polyunsaturated fatty acid supplementation on disease activity in inflammatory rheumatic diseases: a systematic literature review and meta-analysis, Arthritis Research & Therapy (2022) 24:100 https:/ /d.
org/11186/s13075-022-02781-2[2]Rizos EC, Markozannes G, Tsapas A, Mantzoros CS, Ntzani .
