Can a ketogenic diet improve osteoarthritis?

*For medical professionals to read and refer to clinical information, 1s touches ▎Clinical question: What protective mechanism does ketogenic diet (KD) use to improve osteoarthritis (OA)? Screenshot of the literature▎Research protocol: This study used anterior cruciate ligament amputation (ACLT) and partial medial meniscectomy to establish a rat knee OA mod.
After 8 weeks of KD or standard diet (SD) treatment, rat knee specimens were taken for testi.
▎Main findings: KD significantly increased the content of β-hydroxybutyric acid (βOHB) in ra.
Compared with SD group, KD significantly reduced the damage caused by OA in articular cartilage and subchondral bo.
Compared with the sham-operated group, the NLRP3 inflammasome and the inflammatory factors interleukin-1β (IL-1β) and interleukin-18 (IL-18) were significantly increased in the SD group, while the levels of these factors were significantly higher in the KD gro.
expression was significantly decreas.
▎Deficiencies and prospects: In conclusion, KD can inhibit the activation of the NLRP3 inflammasome and reduce the inflammatory response of OA, and protect the articular cartilage and subchondral bone of the OA rat mod.
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