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A&R: A risk score for detecting subclinical rheumatoid arthritis-associated interstitial lung disease

 Last Update: 2022-08-12
 Source: Internet
 Author: User

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OBJECTIVE: The course of subclinical rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is heterogeneous; some patients may experience disease progression leading to pulmonary symptoms and decreased respiratory functi.

Methods: One discovery sample and one validation sample were obtained from patients without pulmonary symptoms in 2 prospective RA cohorts ( ESPOIR and TRANSLATE2 ) who underwent chest HRCT scan.

RESULTS: The discovery and replication populations included 163 and 89 patients , respective.

Conclusions: This study identifies and validates a risk score for RA-ILD with or without MUC5B rs35705950 MUC5B rs35705950 that identifies patients at high risk for subclinical RA-ILD requiring screening with chest HRCT scan.

Source: Juge,.

Juge,.
.
, Granger,.
, et .
(2022), A Risk Score to Detect Subclinical Rheumatoid Arthritis-Associated Interstitial Lung Disea.
Arthritis Rheumat.
Accepted Author Manuscri.
https://d.
org/11002 /a.
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