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A&R: Association of body mass index with pain and the mediating role of inflammatory biomarkers in patients with osteoarthritis of the hand

 Last Update: 2022-08-12
 Source: Internet
 Author: User

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Objectives: To investigate the association of body mass index (BMI) with pain in patients with osteoarthritis (OA) of the hand , and to explore whether this association, if causal, is mediated by systemic inflammatory biomarke.

METHODS: Among 281 Nor-Hand study participants, we estimated BMI with the Australian / Canadian Hand Osteoarthritis Index ( AUSCAN ; range 0-20 ) and Numerical Rating Scale ( NRS ; range 0-10.

Results: Each 5 -unit increase in BMI was associated with more severe hand pain ( mean increase in AUSCAN 64 [95% confidence interval (95% CI) 23, 08] ), foot pain ( mean increase in NRS 65 [95% CI 36, 92]) , knee / hip pain ( mean WOMAC increase of 31 [95% CI 87 to 73] ), generalized pain, and increased pain sensitivit.

Conclusions: Among patients with hand OA , higher BMI was associated with pain severity in the hands, feet, and knee / hi.

Source: Gløersen,.

Gløersen,.
, Steen Pettersen,.
, Neogi,.
, Jafarzadeh, SR, Vistnes,.
, Thudium, CS, Bay-Jensen,.
.
, Sexton,.
, Kvien, TK, Hammer, HB and Haugen, IK (2022), Associations of Body Mass Index With Pain and the Mediating Role of Inflammatory Biomarkers in People With Hand Osteoarthrit.
Arthritis Rheumatol, 74: 810-81https://d.
org/11002/a.
42056 https://d.

org/11002/a.

42056Leave a comment here

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