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A&R: In vivo multidimensional immunoassay of cutaneous lupus erythematosus stratified by patient response to antimalarial drugs

 Last Update: 2022-08-12
 Source: Internet
 Author: User

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Objective: The pathogenesis of cutaneous lupus erythematosus (CLE) is multifactorial, and CLE is difficult to treat due to the heterogeneity of the inflammatory process among patient.

Methods: We performed image-quality flow cytometry on 48 treatment-naïve skin biopsies from HCQ responders, QC responders, and non-responders (NR) to analyze multiple immune cells in the native environment of CLE skin types and inflammatory marker.

Results: HCQ responders showed increased CD4 T cells compared to Q.

Conclusions: These findings demonstrate that the immune composition differs between CLE patients and guide a future based on precision medicine and treatment respons.

Source: Patel,.

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, Vazquez,.
, Chin,.
, Keyes,.
, Yan,.
, Diaz,.
, Grinnell,.
, Sharma,.
, Li,.
, Feng,.
, Sprow,.
, Dan,.
and Werth, VP (2022), Multidimensional immune profiling of cutaneous lupus erythematosusin vivo https://d.
org/11002/a.
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