The increase of this factor will actually lead to an increase in the mortality rate of rheumatoid patients?

For medical professionals to read and refer to clinical information, 1s touches  Clinical question: Is there a correlation between adipokines levels and the prognosis of rheumatoid arthritis (RA) patients? A study from Rheumatology showed that elevated adipokines were associated with poorer prognosis in RA patients

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Screenshot of the literature Research protocol: A total of 2583 adult RA patients from the Department of Veterans Affairs were included in this study

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Adipokines and inflammatory factors were measured at enrollment as part of a multiple analysis panel

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Date of death and cause of death from Corporate Data Warehouse and National Death Index

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Covariates were derived from case, biobank, and registry databases

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Multivariate Cox proportional hazards models assessed associations between biomarkers and all-cause and cause-specific mortality

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Key findings: Higher adiponectin levels were associated with older age, males, Caucasians, lower body mass index (BMI), autoantibody seropositivity, imaging damage, longer disease duration, use of prednisone and bone associated with osteoporosis; higher adiponectin concentrations were also associated with higher levels of inflammatory factors, but not with higher disease activity at enrollment

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After accounting for covariates, the highest quartile of adiponectin (compared with the lowest quartile) was associated with higher all-cause mortality (HR: 1.46, 95% CI 1.11-1.93, P=0.009) was associated with higher cardiovascular mortality (HR: 1.85, 95%CI 1.24-2.75, P=0.003).

Leptin was primarily associated with higher BMI and comorbidities; higher leptin levels were also associated with higher all-cause and cancer mortality
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Deficiencies and Outlook: In conclusion, elevated adipokines are associated with age, BMI, comorbidities, and severity of RA, and can independently predict early death
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The correlation between adiponectin and inflammatory factors supports the hypothesis that chronic subclinical inflammation promotes metabolic changes that lead to elevated adipokines with adverse outcomes
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