When gout flares up after vaccination, colchicine reduces risk by 47%!

*For medical professionals to read and refer to clinical information, 1s touches ▎Clinical question: What is the risk of gout attack 3 months after vaccination with COVID-19? Can colchicine prevent gout attacks after COVID-19 vaccination? Screenshot of the literature▎Research plan: From February to October 2021, a population-based clinical cross-sectional study was conducted in the gout clinic of Qingdao University Affiliated Hospital
.

Study participants were selected in follow-up gout patients using a systematic random sampling method
.

A total of 549 gout participants (median age 39 years, 84.
2% vaccinated) were recruited
.

▎Main finding: Among the 462 patients who received the COVID-19 vaccine, 203 (43.
9%) had at least one gout attack within 3 months of vaccination
.

Most gout flares occurred within 1 month of the first [99/119 (83.
2%)] or second [70/115 (60.
9%)] vaccine doses
.

 Vaccination was associated with an increased risk of gout flares within 3 months compared with participants who were not vaccinated against COVID-19 (adjusted OR 6.
02; 95% CI 3.
00-12.
08)
.

Colchicine reduces the risk of gout attacks by 47% after vaccination
.

▎Conclusion: In conclusion, COVID-19 vaccination was associated with an increased risk of gout attacks, which occurred mainly in the first month after each vaccination, and was inversely associated with colchicine prophylaxis
.

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