 Home > Active Ingredient News > Immunology News > ARD: Mechanical overload promotes chondrocyte senescence and osteoarthritis development through downregulation of FBXW7

ARD: Mechanical overload promotes chondrocyte senescence and osteoarthritis development through downregulation of FBXW7

 Last Update: 2022-05-25
 Source: Internet
 Author: User

Tags

harp mechanical

short careers study

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Objective: Mechanical overload and chondrocyte senescence play important roles in the development of osteoarthritis (OA) .

Methods: The expression of F-box and WD repeat domain 7 (FBXW7) ubiquitin ligase and chondrocyte senescence were detectedin vitro, in experimental OA mouse and human OA cartilage .

Results: Mechanical overload accelerated the aging of cultured chondrocytes and mouse articular cartilage

Conclusions: FBXW7 is a key factor in the association of mechanical overload with chondrocyte senescence and cartilage aging in OA pathology .

Source: Zhang H, Shao Y, Yao Z , et al.
Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7.
Annals of the Rheumatic Diseases 2022; 81: 676-686.
, et al.
Annals of the Rheumatic Diseases 81:

leave a message here

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

Related Products

High Purity 99% BPN14770 Zatolmilast 1606974-33-7 In Stock Fast Ship to USA

CAS No.: 1606974-33-7

Pharm Grade

$1-1.1/UNIT FOB

High quality Thymosin α1 Pure CAS 62304-98-7 Thymosin Alpha 1 Thymalfasin

CAS No.: 62304-98-7

Pharmacy Grade

$12-15/UNIT FOB

Top quantity Imiquimod CAS NO 99011-02-6 White crystalline powder 99% API

CAS No.: 99011-02-6

Pharmacy Grade

$1800-1850/KG FOB

Hot Tags

united states jobs(223)

jobs united states(236)

1 year treasury(277)

1 year subscription(296)

single use technology(195)

announcements today(81)

ups united states(221)

united states logo(227)

80 20 company(94)

healthy food name(42)

Hot Articles

The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.