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ARD: Mechanical overload promotes chondrocyte senescence and osteoarthritis development through downregulation of FBXW7

 Last Update: 2022-05-25
 Source: Internet
 Author: User

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Objective: Mechanical overload and chondrocyte senescence play important roles in the development of osteoarthritis (OA) .

Methods: The expression of F-box and WD repeat domain 7 (FBXW7) ubiquitin ligase and chondrocyte senescence were detectedin vitro, in experimental OA mouse and human OA cartilage .

Results: Mechanical overload accelerated the aging of cultured chondrocytes and mouse articular cartilage

Conclusions: FBXW7 is a key factor in the association of mechanical overload with chondrocyte senescence and cartilage aging in OA pathology .

Source: Zhang H, Shao Y, Yao Z , et al.
Mechanical overloading promotes chondrocyte senescence and osteoarthritis development through downregulating FBXW7.
Annals of the Rheumatic Diseases 2022; 81: 676-686.
, et al.
Annals of the Rheumatic Diseases 81:

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