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A&R: The essential role of hematopoietic PAD4 in arthritis: collagen and granulocyte colony-stimulating factor-induced arthritis in the C57BL/6 mouse model

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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leukemia inhibitory factor

collagen effects

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Objective : Genome-wide association studies have linked PADI4 , encoding peptidyl arginine deaminase 4 (PAD4) , with rheumatoid arthritis (RA.

Objective Genome-wide association studies have linked PADI4 , encoding peptidyl arginine deaminase 4 (PAD4) , with rheumatoid arthritis (RA.

Methods : To effectively use C57BL/6 mice in a collagen-induced arthritis (CIA) model, we introduced granulocyte colony-stimulating factor (G-CSF) with an immunopotentiator on day 21 for 4 consecutive day.

Methods To effectively use C57BL/6 mice in a collagen-induced arthritis (CIA) model, we introduced granulocyte colony-stimulating factor (G-CSF) with an immunopotentiator on day 21 for 4 consecutive day.

Results G-CSF significantly increased the incidence and severity of CI.

Conclusion The research team has successfully developed an arthritis model suitable for C57BL/6 mice, which fully meets the high standards of animal welfar.

Source: Fukui,.
, Gutch,.
, Fukui,.
, Cherpokova,.
, Aymonnier,.
, Sheehy, CE, Chu,.
and Wagner, DD (2022), The Prominent Role of Hematopoietic Peptidyl Arginine Deiminase 4 in Arthritis: Collagen- and Granulocyte Colony-Stimulating Factor–Induced Arthritis Model in C57BL/6 Mi.
Arthritis Rheumatol, 74: 1139-114 https://d.
org/11002/a.
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