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A&R: Efficacy advantage of low-dose benzbromarone in gout patients with insufficient renal uric acid excretion

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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Objectives: The primary mechanism responsible for hyperuricemia in gout is insufficient renal uric acid excretion , however, regardless of the cause of hyperuricemia, the standard uric acid lowering therapy (ULT) recommendation is first-line xanthine oxidase inhibition (XOI)

Gout Hyperuricemia Gout Hyperuricemia Renal Insufficiency of Excretion of Uric Acid Sutent efficacy comparison clinical trial efficacy comparison clinical trial

Methods: A prospective, randomized, single-center, open-label trial of men with gout and renal insufficiency of uric acid excretion (defined as fractional uric acid excretion <5% and uric acid excretion ≤ 600 mg/day/73 m ².

^Low-dose benzbromarone 25 mg daily and low-dose febuxostat 20 mg dai.

RESULTS: Compared with LDFeb, more people in the LDBen group achieved serum uric acid goals (61% vs 32%, P < 00

More people in the LDBen group achieved serum uric acid targets P P

CONCLUSIONS: Low-dose benzbromarone has greater serum uric acid-lowering efficacy than low-dose febuxostat in relatively young and healthy gout patients with renal insufficien.

low-dose benzbromarone low-dose benzbromarone has greater serum uric acid lowering efficacy has greater serum uric acid lowering efficacy

Source:

Yan F, Xue X, Lu J, et .

Yan F, Xue X, Lu J, et .
Superiority of low-dose benzbromarone to low-dose febuxostat in a prospective, randomized comparative effectiveness trial in gout patients with renal uric acid underexcretion [published online ahead of print, 2022 Jul 7.
Arthritis Rheumat.
2022;11002/a.
4226 doi:11002/a.
42266 Leave a comment here

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