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Rheumatology: Associations between psoriasis and lifestyle factors and comorbidities - a cross-sectional analysis and Mendelian randomization

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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OBJECTIVE: To investigate the association between psoriatic arthritis (PsA) and psoriasis , life> and comorbidities using triangulation observations and genetic eviden.

Psoriatic Arthritis (PsA) Psoriatic Arthritis (PsA) Psoriasis Life>Comorbidities

METHODS: Cross-sectional data from the UK Biobank (1836 PsA, 8995 psoriasis, and 36000 controls) were analysed using logistic models adjusted for age, gender and life>BMI and smoking ) and 15 comorbidities including diabetes and coronary artery disease (CAD.

logistic model BMI smoking diabetes coronary artery disease (CAD)

Two-way Mendelian randomization (MR) was applied to genome-wide association data (3609 PsA and 7804 psoriasis cases, life>

Mendelian randomization (MR) genome-wide association data

RESULTS: BMI was cross-sectionally associated with risk of PsA (OR 31 per 5 kg/m 2 increase ; ⁹⁵ % CI 26-37) and psoriasis (OR 23; 20-26) , as predicted by MR (PsA OR 38, 14-67; psoriasis OR 36, 18-58.

²Risk-Related Smoking and Psoriasis More Closely Associated Than PsA

Genetically predicted glycated hemoglobin (a surrogate for diabetes) increased PsA risk (OR 18, 7 mmol/mol per increase; 02-36), while psoriasis was unaffected

Increased PsA Risk Psoriasis Unaffected Genetic Predisposition Associated with Increased CAD Risk

CONCLUSIONS: Observational and genetic evidence consistently suggests that BMI and glycemic control are associated with an increased risk of psoriasis, and psoriasis is associated with an increased risk of CAD

BMI and glycemic control are associated with increased risk of psoriasis, while psoriasis is associated with increased risk of CAD BMI and glycemic control are associated with increased risk of psoriasis, and psoriasis is associated with increased risk of CAD

Source:

Zhao SS, Bellou E, Verstappen SMM, et .

Zhao SS, Bellou E, Verstappen SMM, et .
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