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A&R: B cell counts predict humoral and cellular responses to SARS-CoV-2 vaccine in patients receiving rituximab

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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OBJECTIVE: Patients with autoimmune inflammatory rheumatic disease treated with rituximab (RTX) were at higher risk of poor prognosis from COVID-19 infection and significantly impaired humoral immune responses against SARS-CoV-2 vacci.

The complex relationship between antigen-specific B cells and T cells and the level of B cell repopulation required to achieve an anti-vaccine response remains largely unkno.

RESULTS: Following SARS-CoV-2 vaccination, RTX-treated patients appeared to require at least 10 B cells (4% lymphocytes) per microliter of peripheral circulation to seroconvert to anti-Spike S1 I.

Following SARS-CoV-2 vaccination, RTX-treated patients appear to require at least 10 B cells (4% lymphocytes) per microliter in peripheral circulation to seroconvert to anti-Spike S1 I.

In RTX-treated patients, at least 10 B cells per microliter in the peripheral circulation are a candidate biomarker with a high likelihood of appropriate cellular and humoral responses following SARS-CoV-2 vaccinati.

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