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ARD: Mechanism of action of baricitinib in patients with active systemic lupus erythematosus and identification of biomarkers and key immune pathways
Time of Update: 2022-08-16
1136/ annrheumdis-2022-222335 , et al Annals of the Rheumatic Diseases leave a comment here OBJECTIVE : To elucidate the mechanism of action of baricitinib , a Janus kinase (JAK) 1/2 inhibitor , and to describe disease activity-related disease activity in adult patients with systemic lupus erythematosus (SLE) receiving standard background therapy in a phase II trial.
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Rheumatology (Oxford): How effective are adipose tissue-derived stromal vessels in patients with systemic sclerosis?
Time of Update: 2022-08-16
A study published in Rheumatology (Oxford) evaluated the superiority of finger injection of adipose tissue-derived stromal vascular fraction (AD-SVF) compared with placebo in reducing hand disability in patients with SSc .
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A&R: Prevalence of Site-Specific Osteoarthritis 1990-2019: Findings from the Global Burden of Disease Study 2019
Time of Update: 2022-08-16
Objectives To estimate systemic and anatomical site-specific age-standardized prevalence rates (ASR) of osteoarthritis (OA) and to analyze long-term trends in OA at global, regional, and national levels .
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BJD: Keep cutting, keep chaotic ~ The relationship between gastrointestinal microbiota and psoriasis
Time of Update: 2022-08-16
studied the gut microbiota of psoriasis patients and age-, sex-, and BMI-matched healthy controls, and also provided longitudinal data to examine the stability of the gut microbiota over time .
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A&R: Epigenetic regulation of profibrotic macrophages in systemic sclerosis-associated interstitial lung disease
Time of Update: 2022-08-16
Single Cell RNA Sequencing Single Cell ATAC Sequencing Signac/Seurat Binding Site Transcription FactorsRESULTS: By scRNA-seq analysis, distinct macrophage subsets were identified in normal and SSc-ILD lungs, and gene expression changes that occurred during the transition of normal macrophages to SPP1 macrophages were determined .
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A&R: Interleukin-4-induced epithelial cell senescence as a novel therapeutic target for IgG4-related sialadenitis
Time of Update: 2022-08-16
. RESULTS : Salivary acinar and ductal epithelial cells undergo senescence in IgG4-RS patients with increased senescence-associated β - galactosidase activity, lipofuscin accumulation, enhanced expression of senescence markers ( p53 and p16 INK4A ), and senescence-associated The secreted phenotype factor was up-regulated .
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A&R: Using a polygenic risk score to assess the risk of hip and knee osteoarthritis
Time of Update: 2022-08-16
METHODS : We analyzed 12,732 individuals from a population-based cohort ( RS ; n=11496 ), a clinical cohort ( CHECK ; n=908 ) and a high-risk cohort of overweight women ( PROOF ; n=328 ) from the Rotterdam Study Subjects, Associations between PRS and prevalence / incidence of radiographic OA , clinical OA , and total hip or knee replacement (THR/TKR) .
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Lancet: Early Food Interventions and Skin Emollients Prevent Food Allergies in Young Children (PreventADALL Study)
Time of Update: 2022-08-16
backgroundInitial prevention of food allergies through early introduction of allergenic foods appears promising . Our aim was to determine whether early introduction of food or the use of conventional
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A&R: Central role of Semaphorin 3B in a serum-induced arthritis model and reduced levels in rheumatoid arthritis patients
Time of Update: 2022-08-16
Administration of recombinant mouse Sema3B reduced the clinical severity of serum-induced arthritis and the expression of inflammatory mediators .
Administration of recombinant mouse Sema3B reduced the clinical severity of serum-induced arthritis and the expression of inflammatory mediators .
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A&R: Modulation of the itaconic acid pathway alleviates lupus in mice
Time of Update: 2022-08-16
Itaconic acid Itaconic acid controls inflammasome activation, type I interferon (IFN) response and oxidative stress in systemic lupus erythematosus (SLE)Methods: Female New Zealand Black/New Zealand White F1 lupus-susceptible mice were administered 4-octylitaconic acid (4-OI) or vehicle for 4 weeks after clinical onset (30 weeks of age) (10 mice/group).
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A&R: Intensive oral uric acid lowering does not improve bone erosion scores in erosive gout patients
Time of Update: 2022-08-16
42055 Leave a comment here Objective : To determine whether intensive serum uric acid-lowering therapy improves bone erosion scores in patients with erosive gout .
42055 Leave a comment here Objective : To determine whether intensive serum uric acid-lowering therapy improves bone erosion scores in patients with erosive gout .
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HCQ may have slight benefit for proteinuria in patients with IgA nephropathy
Time of Update: 2022-08-16
Flowchart of path selection:Flowchart of path selection:Methods: PubMed and Embase were systematically searched for studies through June 2021 comparing HCQ and other treatments to reduce proteinuria in patients with IgA nephropathy .
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Rising temperatures, be wary of rheumatism patients susceptible to shingles!
Time of Update: 2022-08-16
Symptoms may precede the onset:What should I do if there is shingles in rheumatism?What should I do if there is shingles in rheumatism?Rheumatism combined with herpes zoster has certain particularities, and there are also a few patients with atypical symptoms.
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Is uric acid really useless?
Time of Update: 2022-08-16
In addition, a large number of studies at home and abroad in recent years have shown that there is a significant negative correlation between serum uric acid levels and the onset risk and progression of Parkinson 's disease (Parkinson's disease is a common neurodegenerative disease in the middle-aged and elderly) .
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ARD: NLRP3 inflammasome-activated Tfh cells are critical for high-affinity antibody production, germinal center formation, and autoimmunity
Time of Update: 2022-08-15
The present study examined the role of NLRP3 inflammasome activation in the regulation of T follicular helper (Tfh) cells in humoral responses to T -dependent antigens and in systemic lupus erythematosus (SLE) .
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JAMA Dermatol: Nomacopan is well tolerated and effective in elderly patients with bullous pemphigoid
Time of Update: 2022-08-15
Secondary endpoints included mean absolute and percent change in papular lupus erythematosus disease area index (BPDAI) activity score, BPDAI pruritus score, and patient-reported outcome measures Dermatology Life Quality Index (DLQI) and autoimmune papular disease treatment Quality of Life (TABQOL) .
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These 5 high-risk factors that easily lead to femoral head necrosis, the coup is very simple!
Time of Update: 2022-08-15
Disturbance of the immune system, thereby aggravating inflammation of blood vessels, and finally leading to necrosis of the femoral head TipsTips Hormone withdrawal has attracted much attention from Butterfly Friends.
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Rheumatology: Histidine is a biomarker in the pathogenesis of systemic lupus erythematosus
Time of Update: 2022-08-15
1093/rheumatology/keac338 leave a message here Objective: To study the changes of metabolites in the plasma of patients with systemic lupus erythematosus (SLE) to identify new biomarkers and provide clues for the pathogenesis of SLE .
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Rheumatology: Nailfold video capillary microscopy is a useful tool for evaluating ANCA-associated vasculitis
Time of Update: 2022-08-15
1093/rheumatology/keac402 leave a message here Objectives: To evaluate nailfold video capillary technique (NVC) as a useful tool to assess disease activity in anti- neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) .
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A&R: The role of microRNA-27b-3p in synovial fibrosis in knee osteoarthritis
Time of Update: 2022-08-15
Induced synovial fibrosis-like phenotype with increased synovitis score and increased COL1A1 and α-SMA expressionMiR-27b-3p mimetic treatment of human OA-FLS induced profibrotic responses including increased migration and expression of key extracellular matrix (ECM) genes , whereas inhibitor transfection had the opposite effect .
