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Is uric acid really useless?
Time of Update: 2022-08-16
In addition, a large number of studies at home and abroad in recent years have shown that there is a significant negative correlation between serum uric acid levels and the onset risk and progression of Parkinson 's disease (Parkinson's disease is a common neurodegenerative disease in the middle-aged and elderly) .
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Lancet: Early Food Interventions and Skin Emollients Prevent Food Allergies in Young Children (PreventADALL Study)
Time of Update: 2022-08-16
backgroundInitial prevention of food allergies through early introduction of allergenic foods appears promising . Our aim was to determine whether early introduction of food or the use of conventional
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A&R: Using a polygenic risk score to assess the risk of hip and knee osteoarthritis
Time of Update: 2022-08-16
METHODS : We analyzed 12,732 individuals from a population-based cohort ( RS ; n=11496 ), a clinical cohort ( CHECK ; n=908 ) and a high-risk cohort of overweight women ( PROOF ; n=328 ) from the Rotterdam Study Subjects, Associations between PRS and prevalence / incidence of radiographic OA , clinical OA , and total hip or knee replacement (THR/TKR) .
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Rising temperatures, be wary of rheumatism patients susceptible to shingles!
Time of Update: 2022-08-16
Symptoms may precede the onset:What should I do if there is shingles in rheumatism?What should I do if there is shingles in rheumatism?Rheumatism combined with herpes zoster has certain particularities, and there are also a few patients with atypical symptoms.
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Paid promotion: 1 minute to register the applet and get 20 yuan WeChat red envelope
Time of Update: 2022-08-16
Participation will be rewarded, and the inspection department will give priority to the awardAfter completing the registration, send the screenshot to the assistant to receive the reward.
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ARD: Mechanism of action of baricitinib in patients with active systemic lupus erythematosus and identification of biomarkers and key immune pathways
Time of Update: 2022-08-16
1136/ annrheumdis-2022-222335 , et al Annals of the Rheumatic Diseases leave a comment here OBJECTIVE : To elucidate the mechanism of action of baricitinib , a Janus kinase (JAK) 1/2 inhibitor , and to describe disease activity-related disease activity in adult patients with systemic lupus erythematosus (SLE) receiving standard background therapy in a phase II trial.
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BJD: Keep cutting, keep chaotic ~ The relationship between gastrointestinal microbiota and psoriasis
Time of Update: 2022-08-16
studied the gut microbiota of psoriasis patients and age-, sex-, and BMI-matched healthy controls, and also provided longitudinal data to examine the stability of the gut microbiota over time .
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A&R: Efficacy advantage of low-dose benzbromarone in gout patients with insufficient renal uric acid excretion
Time of Update: 2022-08-16
Here, we compared the efficacy of first-line non-titrated, low-dose benzbromarone urate-lowering therapy with XOI ULT, a low-dose febuxostat , in gout with insufficient renal uric acid excretion .
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A&R: Central role of Semaphorin 3B in a serum-induced arthritis model and reduced levels in rheumatoid arthritis patients
Time of Update: 2022-08-16
Administration of recombinant mouse Sema3B reduced the clinical severity of serum-induced arthritis and the expression of inflammatory mediators .
Administration of recombinant mouse Sema3B reduced the clinical severity of serum-induced arthritis and the expression of inflammatory mediators .
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Hair loss in SLE patients is a recurrence?
Time of Update: 2022-08-16
Excessive intake of nutrients (eg: iron, copper, zinc) (vitamins B2, C, E, H) (eg vitamin A and selenium)frequent shampooingWashing hair too frequently, especially using overly powerful shampoo products , and vigorously scratching the scalp during shampooing can damage the cortex, weaken the skin barrier, and make the oil secretion more vigorous, resulting in itchy scalp It even stimulates hair follicles, causing seborrheic dermatitis or microbial infection to cause hair loss [4] .
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A&R: Epigenetic regulation of profibrotic macrophages in systemic sclerosis-associated interstitial lung disease
Time of Update: 2022-08-16
Single Cell RNA Sequencing Single Cell ATAC Sequencing Signac/Seurat Binding Site Transcription FactorsRESULTS: By scRNA-seq analysis, distinct macrophage subsets were identified in normal and SSc-ILD lungs, and gene expression changes that occurred during the transition of normal macrophages to SPP1 macrophages were determined .
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A&R: Prevalence of Site-Specific Osteoarthritis 1990-2019: Findings from the Global Burden of Disease Study 2019
Time of Update: 2022-08-16
Objectives To estimate systemic and anatomical site-specific age-standardized prevalence rates (ASR) of osteoarthritis (OA) and to analyze long-term trends in OA at global, regional, and national levels .
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A&R: B cell counts predict humoral and cellular responses to SARS-CoV-2 vaccine in patients receiving rituximab
Time of Update: 2022-08-16
. In RTX-treated patients, at least 10 B cells per microliter in the peripheral circulation are a candidate biomarker with a high likelihood of appropriate cellular and humoral responses following SARS-CoV-2 vaccination .
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Rheumatology: Associations between psoriasis and lifestyle factors and comorbidities - a cross-sectional analysis and Mendelian randomization
Time of Update: 2022-08-16
Psoriatic Arthritis (PsA) Psoriatic Arthritis (PsA) Psoriasis Life>ComorbiditiesMETHODS: Cross-sectional data from the UK Biobank (1836 PsA, 8995 psoriasis, and 36000 controls) were analysed using logistic models adjusted for age, gender and life>BMI and smoking ) and 15 comorbidities including diabetes and coronary artery disease (CAD ) .
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Rheumatology: Histidine is a biomarker in the pathogenesis of systemic lupus erythematosus
Time of Update: 2022-08-15
1093/rheumatology/keac338 leave a message here Objective: To study the changes of metabolites in the plasma of patients with systemic lupus erythematosus (SLE) to identify new biomarkers and provide clues for the pathogenesis of SLE .
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Rheumatology: Nailfold video capillary microscopy is a useful tool for evaluating ANCA-associated vasculitis
Time of Update: 2022-08-15
1093/rheumatology/keac402 leave a message here Objectives: To evaluate nailfold video capillary technique (NVC) as a useful tool to assess disease activity in anti- neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) .
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Cell︱Prokaryotic new mechanism of self-protection immunity
Time of Update: 2022-08-15
The role and mechanism of the (SPARTA) system, which identifies SPARTA as a prokaryotic immune system, confirms that in RNA-guided detection of invading DNA, "short" pAgo and related proteins can co-trigger NAD(P)+ depletion, leading to invasion by decreased cell viability, thereby removing it from bacterial cultures .
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JAMA Dermatol: Nomacopan is well tolerated and effective in elderly patients with bullous pemphigoid
Time of Update: 2022-08-15
Secondary endpoints included mean absolute and percent change in papular lupus erythematosus disease area index (BPDAI) activity score, BPDAI pruritus score, and patient-reported outcome measures Dermatology Life Quality Index (DLQI) and autoimmune papular disease treatment Quality of Life (TABQOL) .
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These 5 high-risk factors that easily lead to femoral head necrosis, the coup is very simple!
Time of Update: 2022-08-15
Disturbance of the immune system, thereby aggravating inflammation of blood vessels, and finally leading to necrosis of the femoral head TipsTips Hormone withdrawal has attracted much attention from Butterfly Friends.
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ARD: NLRP3 inflammasome-activated Tfh cells are critical for high-affinity antibody production, germinal center formation, and autoimmunity
Time of Update: 2022-08-15
The present study examined the role of NLRP3 inflammasome activation in the regulation of T follicular helper (Tfh) cells in humoral responses to T -dependent antigens and in systemic lupus erythematosus (SLE) .