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A&R: Interleukin-4-induced epithelial cell senescence as a novel therapeutic target for IgG4-related sialadenitis

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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Objective : IgG4 - related disease (IgG4-RD) is a systemic fibroinflammatory disease characterized by increased infiltration of IgG4+ plasma cells and striated fibrosis in multiple organs including salivary, pancreas, lacrimal, and kidne.

OBJECTIVE : IgG4 - related disease ( IgG4-RD) is a systemic fibroinflammatory disease characterized by increased IgG4+ plasma cell infiltration and striated fibrosis in multiple organs including salivary, pancreas, lacrimal and kidne.

Methods : Determination of senescence markers and pro-inflammatory cytokines in the submandibular gland (SMG) of IgG4-RS patients (n=18) and controls (n=14) by proteomics, real-time polymerase chain reaction, western blot and immunohistochemistry expressio.

Methods : Determination of senescence markers and proinflammatory cells in the submandibular gland (SMG) of IgG4-RS patients (n=18) and controls (n=14) by proteomics, real-time polymerase chain reaction, western blot and immunohistochemistry factor expressio.

Results Salivary acinar and ductal epithelial cells undergo senescence in IgG4-RS patients with increased senescence-associated β - galactosidase activity, lipofuscin accumulation, enhanced expression of senescence markers ( p53 and p16 ^INK4A^{INK4A ), and senescence-associated}The secreted phenotype factor was up-regulate.

Conclusion IL-4 promotes the fibrosis of IgG4-RS through cell senescence induced by ROS/p38 MAPK-p16 ^INK4A^{INK4A pathway} The data from this study suggest that cellular senescence could serve as a novel therapeutic target for the treatment of IgG4-R.

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(2022), Contribution of Interleukin-4–Induced Epithelial Cell Senescence to Glandular Fibrosis in IgG4-Related Sialadenit.

Arthritis Rheumatol, 74: 1070-108https:// d.

org/11002/a.

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