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A&R: Using a polygenic risk score to assess the risk of hip and knee osteoarthritis

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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Purpose : The polygenic risk score (PRS) allows risk stratification using common single nucleotide polymorphisms ( SNPs ) and is currently being explored for clinical application in several diseas.

Objectives : The polygenic risk score (PRS) allows risk stratification using common SNPs and is currently being explored for clinical application in several diseas.

Methods : Researchers analyzed 12,732 subjects from the population-based cohort of the Rotterdam Study ( RS ; n=11496 ), a clinical cohort ( CHECK ; n=908 ), and a high-risk cohort of overweight women ( PROOF ; n=328.

METHODS : We analyzed 12,732 individuals from a population-based cohort ( RS ; n=11496 ), a clinical cohort ( CHECK ; n=908 ) and a high-risk cohort of overweight women ( PROOF ; n=328 ) from the Rotterdam Study Subjects, Associations between PRS and prevalence / incidence of radiographic OA , clinical OA , and total hip or knee replacement (THR/TKR.

Results: Results: Compared with radiographic OA phenotypes, we found that PRS was more strongly associated with clinically defined O.

CONCLUSIONS: Conclusions: The findings validate the association of polygenic risk scores (PRS) across definitions of osteoarthritis (OA.

Sedaghati–Khayat,.
, Boer, CG, Runhaar,.
, Bierma – Zeinstra, SM, Broer,.
, Ikram, MA, Zeggini,.
, Uitterlinden, AG, van Rooij, JG and van Meurs, JB ( 2022), Risk assessment for hip and knee osteoarthritis using polygenic risk scor.
Arthritis Rheumat.
Accepted Author Manuscri.
https://d.
org/11002/a.
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