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OBJECTIVE: Systemic sclerosis-associated interstitial lung disease (SSc ILD) is the leading cause of death in patients with systemic sclerosis (SSc) , with unclear pathogenesis and limited treatment optio.
systemic sclerosis-associated interstitial lung disease (SSc ILD) systemic sclerosis-associated interstitial lung disease (SSc ILD) systemic sclerosis (SSc) pro-fibrotic pro-fibrotic SPP1 SPP1 macrophage macrophage transcriptome and chromatin structure Variety
Methods: Single-cell RNA sequencing was performed on 11 transplanted SSc ILD and healthy control lung samples , and single-cell ATAC sequencing was performed on 5 lung samples to identify alterations in SPP1 macrophage chromatin accessibili.
Single Cell RNA Sequencing Single Cell ATAC Sequencing Signac/Seurat Binding Site Transcription Factors
RESULTS: By scRNA-seq analysis, distinct macrophage subsets were identified in normal and SSc-ILD lungs, and gene expression changes that occurred during the transition of normal macrophages to SPP1 macrophages were determin.
MITF, TFEB, ATF6, SREBF1, BHLHE40, KLF6 ETV5 and/or AP-1 transcription factor family
Conclusions: Our findings reveal potential changes in chromatin structure and transcription factor regulation in pro-fibrotic SPP1 macrophages
Pro-fibrotic SPP1 macrophages Pro-fibrotic SPP1 macrophages Novel targets for the treatment of SSc ILD Novel targets for the treatment of SSc ILD
Source:
Source:Papazoglou A, Huang M, Bulik M, et .
Papazoglou A, Huang M, Bulik M, et .
Epigenetic regulation of profibrotic macrophages in systemic sclerosis- associated interstitial lung disease [published online ahead of print, 2022 Jul 1
Arthritis Rheumat.
2022;11002/a.
4228 doi: 11002/a.
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