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ARD: NLRP3 inflammasome-activated Tfh cells are critical for high-affinity antibody production, germinal center formation, and autoimmunity

 Last Update: 2022-08-15
 Source: Internet
 Author: User

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OBJECTIVE : The NLRP3 inflammasome modulates T cell respons.

Methods NLRP3 inflammasome activation in Tfh cells was investigated in B6 , MRL/lpr and NZM2328 mice, as well as in SLE patients and healthy controls, using fluorescently labeled caspase-1 inhibitor probe.

Results NLRP3 inflammasome activation in Tfh cells after immunization was identified in B6 mic.

Conclusion The activation of the NLRP3 inflammasome in T follicular helper cells is an integral part of the immune respons.

Conclusion: Zhao Z, Xu B, Wang S , et a.

Zhao Z, Xu B, Wang S , et a.
Tfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmuni.
Annals of the Rheumatic Diseases2022; 81: 1006-101 , et al Annals of the Rheumatic Diseases81: leave a message here

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