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ARD: Mechanism of action of baricitinib in patients with active systemic lupus erythematosus and identification of biomarkers and key immune pathways

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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OBJECTIVE : To elucidate the mechanism of action of baricitinib , a Janus kinase (JAK) 1/2 inhibitor , and to describe disease activity-related disease activity in adult patients with systemic lupus erythematosus (SLE) receiving standard background therapy in a phase II tri.

OBJECTIVE: To elucidate the mechanism of action of baricitinib , a Janus kinase (JAK) 1/2 inhibitor , and to characterize disease activity-related immunity in adult patients with systemic lupus erythematosus (SLE) receiving standard background therapy in a phase II tri.

Methods : In a phase II randomized, placebo-controlled study, patients with SLE received either 2mg or 4 mg of baricitini.

Methods In a phase II randomized, placebo-controlled study, patients with SLE received either 2 mg or 4 mg of baricitini.

Results At baseline, SLE sera had marked cytokine dysregulation relative to HC ser.

Conclusions: These results suggest that baricitinib 4 mg downregulates key cytokines that are upregulated in SLE patients and may play a role in a multi-target mechanism beyond the IFN signature, although the clinical relevance remains to be further describe.

Dörner T, Tanaka Y, Dow ER , et a.
Mechanism of action of baricitinib and identification of biomarkers and key immune pathways in patients with active systemic lupus erythematos.
Annals of the Rheumatic DiseasesPublished Online First: 24 May 202 doi: 11136/ annrheumdis-2022-222335 , et al Annals of the Rheumatic Diseasesleave a comment here

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