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Artificial intelligence 3D printing technology solves the "invisible" problems in orthopedic surgery
Time of Update: 2021-10-11
Recently, Zhou Jianlin’s team, associate professor of bone and joint surgery at Wuhan University People’s Hospital, used artificial intelligence 3D printing technology to print out Aunt Zhang’s true positioning model of the acetabular and iliac bone defect, and through the customized guide "navigation" surgery, she accurately performed tumor resection.
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Nutrition is better than rice and noodles, but not the soybean grain amaranth
Time of Update: 2021-10-11
In recent years, grain amaranth has settled down in many parts of the country and has become a special food and feed crop in China .
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Chu Chengcai's research team collaborated to discover a cytokinin signaling pathway hidden in the brassinolide signaling component to regulate rice grain size
Time of Update: 2021-10-11
The classical cytokinin signal transduction depends on the histidine receptor kinase HK , histidine phosphotransferase HP , and the histidine (H) and aspartic acid (D) in the cytokinin response facto
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Chinese Academy of Sciences: Monoclonal antibody targeting ace2 is a powerful broad-spectrum coronavirus blocker
Time of Update: 2021-10-11
This article reports a monoclonal antibody 3E8 against human angiotensin-converting enzyme 2 (ACE2), which can block SARS-CoV-2, SARS-CoV-2 variants, SARS-CoV-NL63 and other coronaviruses The S1 subunit and pseudotyped virus structure have no obvious effect on the physiological activity of ACE2, nor will it cause serious toxicity to ACE2 "knock-in" mice .
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Chinese scholars and foreign collaborators have made progress in the research of high-strength plastic gradient nano-dislocation structure high-entropy alloys
Time of Update: 2021-10-10
It is also superior to other graded nanocrystalline and graded nanotwinned structure metals and alloys in the literature; (CD) The HAADF-STEM results of the typical deformed structure when the tensile strain is 3% show that the plastic deformation of the graded dislocation structure passes through the unique ultra-high Density of sub-ten nanometers of stacking faults and a small amount of twin boundary coordination
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Fang Chao's research group from the School of Basic Medical Sciences published a cover paper in Nano-Micro Letters reporting lymph node metastasis...
Time of Update: 2021-10-10
Recently, the Hai Medical School Professor Fang Chao team Jiaotong University in Nano-Micro Letters journal entitled to cover in the form of " Targeted Labeling Reagent Phthalocyanine for the Node Lymph Metastasis and Homing AN orthotopic Photothermal Therapy in Colorectal Tumor Model " papers .
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New ideas for targeted therapy of drug-resistant leukemia
Time of Update: 2021-10-10
FLT3 mutant AML is particularly sensitive to a class of drugs called e-family tyrosine kinase inhibitors (TKIs), making them the first choice for drug development, said first author David Young, MD, who was in Johns Hopkins The University Kimmel Cancer Center conducted this research .
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Cell Metabolism is a protein that is important for exercise coordination and performance
Time of Update: 2021-10-10
Jorge Correia, the first author of the study and a researcher in the Department of Physiology and Pharmacology of Karolinska Institutet, said: "There is still a lot of work to be done, but we believe this is important for patients with metabolic and neuromuscular diseases, such as Type 2 diabetes and amyotrophic lateral sclerosis (ALS) may have therapeutic value .
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Jeremy D Murray's research team discovered the regulatory mechanism of Medicago truncatula's preference for nitrogen absorption (2021-09-15)
Time of Update: 2021-10-10
5 mediates chloride uptake and nitrate preference" by the Jeremy Murray Research Group of the State Key Laboratory of Plant Molecular Genetics and the Anthony J Miller Laboratory of the John Innes Centre in the United Kingdom.
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Geologically active continents will produce higher biodiversity
Time of Update: 2021-10-10
Mountain architecture brings diversityUnder the leadership of Lo?c Pellissier, professor of landscape ecology, researchers at ETH Zurich are studying this problem with the help of a new computer model that allows them to simulate the diversity of species over millions of years of evolution.
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Immunotherapy to deal with glioma, cell typing is the key!
Time of Update: 2021-10-10
Maria Castro, a professor of neurosurgery, cell and developmental biology at the University of Michigan, said: “For ten years, it has been known that patients with low-grade gliomas with IDH1 mutations have a longer median survival time.
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Anti-cancer "magic drug" must remain humble even if it is really "god"
Time of Update: 2021-10-10
(September 27th "China News Weekly")CAR-T cell therapy and related drugs may be really "sweet" in the treatment of specific cancers .
For CAR-T cell therapy and related "magic drugs" that have received high attention, it is time to pour some cold water .
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Cervical cancer patients reduce the risk of death by 31% PD-1 inhibitors receive FDA priority review
Time of Update: 2021-10-10
On September 28, 2021, Regeneron announced that the US FDA has granted priority to the supplementary biological product license application (sBLA) for the PD-1 inhibitor Libtayo (cemiplimab) jointly developed by the company and Sanofi.
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Nature: Masks to prevent the new crown passed the largest test to date
Time of Update: 2021-10-10
The authors of the study found that surgical masks—rather than cloth masks—reduce the spread of SARS-CoV-2 in the villages where the research team distributes masks and promotes its use .
The researchers then compared the number of COVID-19 cases in the control village and the treatment community .
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The first long-acting HIV preventive treatment that has been given priority review by the FDA is coming?
Time of Update: 2021-10-10
On September 28, 2021, ViiV Healthcare announced that the US FDA has granted Cabotegravir's New Drug Application (NDA) priority review as a long-acting injection therapy for HIV pre-exposure prevention (PrEP) .
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Sun Yat-sen University’s latest article: ALKBH1's key role in vascular calcification
Time of Update: 2021-10-10
The results of the study are based on "ALKBH1-demethylated DNA N6-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease through osteogenic reprogramming.
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Antidepressants can completely inhibit cancer growth in mice
Time of Update: 2021-10-10
Now, researchers at the University of Zurich (UZH) and Zurich University Hospital (USZ) have shown that SSRIs or other drugs that lower peripheral serotonin levels can also slow the growth of cancer in mice .
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Zhu Zaichun's research group from the School of Urban Planning and Design of Shenzhen Institute of Technology published a technical review article in Science
Time of Update: 2021-10-10
abb7772) based on statistical regression method that carbon dioxide fertilization effect on global vegetation photosynthesis 1982 - Significant decline between 2015 and the existing terrestrial ecosystem models significantly underestimated The extent of the decline in the effect of carbon dioxide fertilization .
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Technical Serial No. 2: Application of Cre-loxP site-specific recombination system in the study of conditioned target gene function in mice
Time of Update: 2021-10-10
1. Influencing factors of Cre non-specific/error recombination/random insertion mutation At present, the commonly used Cre mouse models are mostly constructed by traditional transgenic technology, that is, the so-called cell/tissue-specific promoter partial DNA fragmentation strategy, coupled with random insertion of genes, may produce the so-called gene expression position effect and other characteristics, resulting in Cre expression The inaccuracies or leakage of, it is difficult to truly reflect the real desired specificity, resulting in off-target cleavage of Cre expression .
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Technical serialization: Application of Cre-loxP site-specific recombination system in the study of conditioned target gene function in mice
Time of Update: 2021-10-10
The establishment of the Cre-loxP site-specific recombination system (Cre-loxP recombination system for short) provides an effective tool for perfecting the construction of gene-edited mouse models and further researching the function of conditional target genes .
