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Classical antidepressants can help improve modern cancer treatment
Serotonin (Serotonin) is a neurotransmitter, also known as a pleasure hormone because of its beneficial effects on mood
SSRIs can slow down tumor growth
The role of serotonin in carcinogenesis is well known
Although new and effective treatments such as targeted antibodies or immunotherapy have been available for several years, most patients with advanced abdominal tumors such as colon or pancreatic cancer die within a few years after diagnosis
Without serotonin, the immune system recognizes cancer cells again
Cancer cells use serotonin to promote the production of the immunosuppressive molecule PD-L1
Hope for new combination therapies
PD-L1, where serotonin plays a role, is also the target of modern immunotherapy, also known as immune checkpoint inhibitors
"Our research results bring hope to cancer patients because the drugs used have been approved for clinical use," said Pierre-Alain Clavien
Science Translational Medicine
DOI
10.
